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Cannabinoids

Back Clinic Cannabinoids. He lāʻau lapaʻau nā mea kanu, a ke hoʻomau nei ka noiʻi me kēia mau lāʻau lapaʻau ʻē aʻe, loaʻa ka ʻike hou aʻe i ka wā e pili ana i nā koho lapaʻau no nā maʻi like ʻole, nā kūlana, nā maʻi, nā maʻi, etc. hiki iā lākou ke kōkua i nā maʻi, nā mea hiki iā lākou ke hana, a me nā mea hiki ʻole ke hana.

ʻO ka lāʻau marijuana ka mea i ʻike nui ʻia e pili ana i nā cannabinoids. ʻO ia ka cannabinoid kaulana loa tetrahydrocannabinol (THC),ʻo ia ka pūpū e hoʻonāuki i nā manaʻo o ka euphoria.

Ua ʻike nā kānaka ʻepekema i nā cannabinoids wale nō i ka cannabis. Eia naʻe, ua loaʻa i nā noiʻi hou kēia mau ʻano lāʻau lapaʻau like i nā mea kanu he nui, me ka pepa ʻeleʻele, broccoli, kāloti, clove, echinacea, a me ginseng.

ʻAʻole e kiʻekiʻe ʻoe i kēia mau mea kanu a i ʻole nā ​​​​mea ʻala, akā ʻo ka hoʻomaopopo ʻana i ka hopena o kēia mau mea kanu like ʻole i ke kino kanaka hiki ke alakaʻi i nā ʻike olakino koʻikoʻi.


He Nānā hohonu i loko o ka Metabolic Syndrome | El Paso, TX (2021)

He Nānā hohonu i loko o ka Metabolic Syndrome | El Paso, TX (2021)

Ma ka podcast o kēia lā, ʻo Kauka Alex Jimenez, ke kumu aʻoaʻo olakino ʻo Kenna Vaughn, ka luna hoʻoponopono nui ʻo Astrid Ornelas e kūkākūkā e pili ana i ka metabolic syndrome mai kahi ʻokoʻa o ka manaʻo a me nā nutraceuticals ʻē aʻe e hakakā ai i ka mumū.

 

Kauka Alex Jimenez DC*: Welina mai, e nā kāne, aloha mai i ka podcast no Dr. Jimenez a me nā hui. Ke kamaʻilio nei mākou i ka metabolic syndrome i kēia lā, a ke kūkākūkā nei mākou mai kahi ʻano like ʻole. E hāʻawi mākou iā ʻoe i nā ʻōlelo aʻoaʻo maikaʻi loa a hiki ke maʻalahi a hiki ke hana ma ka home. He manaʻo nui loa ka Metabolic Syndrome. Loaʻa iā ia ʻelima mau pilikia nui. He kiʻekiʻe kona koko glucose, loaʻa ka momona o ka ʻōpū, he triglycerides, loaʻa iā ia nā pilikia HDL, a he mea maikaʻi loa ia i kahi hui holoʻokoʻa o nā dynamics e pono ke ana ʻia i ke kumu holoʻokoʻa mākou e kūkākūkā ai i ka metabolic syndrome no ka mea e pili ana i ko mākou kaiāulu. nui loa. No laila, e kūkākūkā ana mākou i kēia mau pilikia kūikawā a pehea e hoʻoponopono ai iā lākou. A hāʻawi iā ʻoe i ka hiki ke hoʻololi i kou nohona i ʻole ʻoe e pau. ʻO ia kekahi o nā maʻi koʻikoʻi e pili ana i ka lāʻau lapaʻau hou i kēia mau lā, waiho ʻia ke hoʻomaopopo ʻia. Ma nā wahi a pau āu e hele ai, e ʻike ʻoe i nā poʻe he nui i loaʻa i ka metabolic syndrome. A he ʻāpana ia o kahi hui, a ʻo ia kahi mea āu e ʻike nui ai ma ʻEulopa. Akā ma ʻAmelika, no ka mea he nui kā mākou mau meaʻai a ʻoi aku ka nui o kā mākou mau papa, hiki iā mākou ke hoʻololi i ko mākou kino i kahi ʻokoʻa ma o ka mea a mākou e ʻai ai. ʻAʻohe maʻi e loli wikiwiki a wikiwiki hoʻi e like me kahi mīkini maikaʻi a me kahi protocol maikaʻi e kōkua iā ʻoe me nā maʻi metabolic a me ka metabolic syndrome. No laila i ka ʻōlelo ʻana, i kēia lā, loaʻa iā mākou kahi pūʻulu kanaka. Loaʻa iā mākou ʻo Astrid Ornelas lāua ʻo Kenna Vaughn, nāna e kūkākūkā a hoʻohui i ka ʻike e kōkua iā mākou i ke kaʻina hana. I kēia manawa, ʻo Kenna Vaughn ko mākou kumu aʻo olakino. ʻO ia ka mea e hana nei ma ko mākou keʻena; i koʻu wā he kauka hoʻomaʻamaʻa i ka lāʻau lapaʻau kino a ke hana nei au me nā poʻe hoʻokahi, aia nā poʻe ʻē aʻe e hana ana me nā pilikia meaʻai a me nā pono meaʻai. He maikaʻi loa koʻu hui ma ʻaneʻi. Loaʻa iā mākou kā mākou mea noiʻi lapaʻau kiʻekiʻe a me ka mea nāna e mālama i ka hapa nui o kā mākou ʻenehana a aia ma ka ʻoki ʻoki o kā mākou hana a me kā mākou ʻepekema. ʻO Mrs. ʻO Ornelas. Mrs. ʻO Ornelas a i ʻole ʻo Astrid, e like me kā mākou kapa ʻana iā ia, he ghetto ʻo ia me ka ʻike. Pilikia ʻo ia me ka ʻepekema. A ʻoiaʻiʻo, ma kahi o mākou. I kēia lā, ke noho nei mākou i kahi honua kahi e hele mai ai ka noiʻi a kuha mai ka NCBI, ʻo ia ka waihona a i ʻole PubMed, hiki i nā poʻe ke ʻike iā mākou e hoʻohana nei i kēia ʻike a hoʻohana mākou i nā mea hana a me nā mea e hana ai. ʻAʻole pololei nā ʻike a pau ma PubMed no ka mea he ʻokoʻa kou mau manaʻo, akā ʻaneʻane like ia me ka manamana lima ma ka pulse ke komo ko mākou manamana lima. Hiki iā mākou ke ʻike i nā mea e pili ana iā ia. Me kekahi mau huaʻōlelo a me kekahi mau makaʻala, e hoʻomaopopo ʻia mākou no nā loli, e ʻōlelo kākou, nā pilikia kōpaʻa meaʻai a i ʻole nā ​​pilikia triglyceride me nā pilikia momona, nā mea e pili ana i nā maʻi metabolic. Hiki iā mākou ke hana i kahi protocol lapaʻau i hoʻololi ʻia e nā kauka a me nā mea noiʻi a me nā PhD a puni ka honua kokoke koke, ʻoiai ma mua o ka paʻi ʻia ʻana. No ka laʻana, i kēia lā ʻo Pepeluali 1. ʻAʻole ia, akā e loaʻa iā mākou nā hopena a me nā haʻawina i hōʻike ʻia e ka National Journal of Cardiology e puka mai ana ma Malaki inā kūpono ia. No laila ua wela ka ʻike ma mua o ka paʻi ʻana, a kōkua ʻo Astrid iā mākou e noʻonoʻo i kēia mau mea a ʻike ʻo ia, "E, ʻike ʻoe, ua loaʻa iā mākou kahi mea wela loa a me kahi mea e kōkua ai i kā mākou poʻe maʻi" a lawe mai i ka N like hoʻokahi, ʻo ia ka hoʻomanawanui- kauka like hoʻokahi. ʻO ka mea maʻi a me ka mea lapaʻau e like me ka mea ʻaʻole mākou e hana i nā protocol kikoʻī no kēlā me kēia kanaka. Hana mākou i nā protocols kūikawā no kēlā me kēia kanaka ke hele mākou i ke kaʻina hana. No laila ke hana nei mākou i kēia, ʻo ka huakaʻi o ka hoʻomaopopo ʻana i ka metabolic syndrome he ikaika a hohonu loa. Hiki iā mākou ke hoʻomaka mai ka nānā wale ʻana i ke kanaka a hiki i ka hana koko, a hiki i ka hoʻololi ʻana i ka meaʻai, i ka hoʻololi metabolic, a hiki i ka hana kelepona e hana ikaika nei. Ana mākou i nā pilikia me BIA a me BMI, a mākou i hana ai me nā podcasts mua. Akā hiki iā mākou ke komo i ka pae, ka genomic a me ka hoʻololi ʻana o nā chromosomes a me nā telomeres i nā chromosomes, hiki iā mākou ke hoʻopili i kā mākou ʻai. OK. ʻO nā alanui āpau e alakaʻi i nā meaʻai. A ʻo kaʻu e ʻōlelo ai ma kekahi ʻano ʻano ʻē, ke alakaʻi nei nā alanui āpau i ka smoothies, OK, smoothies. No ka mea ke nānā mākou i nā smoothies, nānā mākou i nā ʻāpana o ka smoothies a piʻi mai me nā dynamics i hiki ke hoʻololi i kēia manawa. ʻO kaʻu mea e ʻimi nei ke ʻimi au i nā lāʻau lapaʻau, nānā au i nā mea e hoʻomaikaʻi ai ke ola o nā kānaka, a pehea mākou e hana ai i kēia? A no kēlā mau makuahine, hoʻomaopopo lākou ʻaʻole paha lākou i ʻike e hana lākou i kēia, akā ʻaʻole ala ka makuahine e ʻōlelo ana, e hāʻawi wau i kaʻu keiki i ka meaʻai. ʻAʻole, ke hana nei ʻo ia i kahi holoi noʻonoʻo o ka lawe ʻana i ka lumi kuke holoʻokoʻa no ka mea makemake ʻo ia e hoʻokomo i ka meaʻai maikaʻi loa no kā lākou keiki a hāʻawi i kā lākou ʻano koho maikaʻi loa no kā lākou pēpē e hele ai i ka honua a i ʻole ka mālama kula a i ʻole ke kula haʻahaʻa, ma ke kula waena, ma ke kula kiʻekiʻe i hiki i ke keiki ke ulu maikaʻi. ʻAʻohe kanaka e hele i waho me ka manaʻo e hāʻawi wau i kaʻu keiki i ka ʻōpala a. A inā ʻo ia ka hihia, ʻo ia, ʻaʻole maikaʻi paha ia i ka mālama makua. Akā, ʻaʻole mākou e kamaʻilio maikaʻi no ia mea; e kamaʻilio mākou e pili ana i ka meaʻai maikaʻi a me ka hoʻololi ʻana i kēlā mau mea. No laila makemake wau e hoʻolauna iā Kenna i kēia manawa. A e kūkākūkā ana ʻo ia i nā mea a mākou e hana ai ke ʻike mākou i kekahi me nā maʻi metabolic a me kā mākou hoʻokokoke ʻana iā ia. No laila, i kona hele ʻana i kēlā, hiki iā ia ke hoʻomaopopo i ke ʻano o kā mākou loiloi a loiloi i kahi mea maʻi a lawe mai iā ia i hiki iā mākou ke hoʻomaka e loaʻa kahi mana liʻiliʻi no kēlā kanaka.

 

Kenna Vaughn: Mea pono nui. No laila, ʻo ka mea mua, makemake wau e kamaʻilio e pili ana i ka smoothies. He makuahine wau, no laila, i ke kakahiaka, pupule nā ​​mea. ʻAʻole loaʻa iā ʻoe ka manawa e like me kou manaʻo, akā pono ʻoe i kēlā mau meaʻai meaʻai a pēlā pū kāu mau keiki. No laila makemake wau i ka smoothies. He wikiwiki loa lākou. Loaʻa iā ʻoe nā mea a pau āu e pono ai. A manaʻo ka hapa nui o ka poʻe i ka wā e ʻai ai ʻoe, e ʻai ana ʻoe i mea e hoʻopiha ai i kou ʻōpū, akā e ʻai ana ʻoe e hoʻopiha i kāu mau cell. ʻO kāu mau pūnaewele ka mea e pono ai kēlā mau meaʻai. ʻO ia ka mea e lawe ai iā ʻoe me ka ikehu, ka metabolism, nā mea a pau. No laila he koho maikaʻi loa kēlā mau smoothies, a mākou e hāʻawi ai i kā mākou poʻe maʻi. Loaʻa iā mākou kekahi puke me 150 smoothie recipes i maikaʻi no ka anti-aging, kōkua i ka maʻi diabetes, hoʻohaʻahaʻa i ka cholesterol, hoʻomalu i ka mumū, a me nā mea like. No laila hoʻokahi kumu waiwai a mākou e hāʻawi ai i kā mākou poʻe maʻi. Akā he nui nā koho ʻē aʻe no ka poʻe maʻi e hele mai me ka maʻi metabolic.

 

Kauka Alex Jimenez DC*:  Ma mua o kou komo ʻana i laila, e Kenna. E ʻae mai iaʻu e hoʻohui wale aku i kaʻu mea i aʻo ai ʻo ia ka mea e maʻalahi. Pono mākou e lawe i nā home a i ʻole nā ​​​​mea lawe. A ʻo kā mākou e hoʻāʻo nei e hāʻawi iā ʻoe i nā mea hana e hiki ke kōkua iā ʻoe i kēlā kaʻina hana. A e lawe mākou iā ʻoe i ka lumi kuke. E paʻa ana mākou i kou pepeiao, e ʻōlelo ai, a e hōʻike ana mākou iā ʻoe i nā wahi e pono ai mākou e nānā. No laila ua kokoke ʻo Kenna e hāʻawi iā mākou i ka ʻike e pili ana i ka smoothies e kōkua iā mākou i nā loli meaʻai e hiki ai iā mākou ke hāʻawi i ko mākou ʻohana a hoʻololi i kāna pōʻino metabolic e hoʻopilikia ai i nā poʻe he nui i kapa ʻia ʻo metabolic syndrome. Hele i mua.

 

Kenna Vaughn: ʻAe, e like me kāna ʻōlelo ʻana me kēlā mau smoothies. ʻO kahi mea āu e hoʻohui ai i kāu smoothie, ʻo kaʻu mea makemake e hoʻohui i kaʻu ʻo ka spinach. He koho maikaʻi loa ka spinach no ka mea hāʻawi i kou kino i nā meaʻai. Ke loaʻa nei ʻoe i kahi ʻai ʻai hou aku, akā ʻaʻole hiki iā ʻoe ke ʻono iā ia, ʻoiai ke uhi ʻia e ka ʻono maoli āu e ʻike ai i nā huaʻai. No laila he koho maikaʻi loa ia e pili ana i ka smoothies. Akā ʻo kahi mea ʻē aʻe a Kauka Jiménez i ʻōlelo ai he mau mea ʻē aʻe i loko o ka lumi kuke. No laila aia kekahi mau mea hoʻololi ʻē aʻe a mākou e makemake ai i kā mākou poʻe maʻi e hoʻohana a hoʻokō. Hiki iā ʻoe ke hoʻomaka liʻiliʻi, a e hoʻololi nui ia ma ka hoʻololi ʻana i nā ʻaila āu e kuke ai. A e hoʻomaka ana ʻoe e ʻike i ka hoʻomaikaʻi ʻana i kāu mau hui, kāu mau keiki, a e hoʻomaikaʻi maikaʻi nā mea a pau. No laila, hoʻokahi mea a mākou e makemake ai e hoʻohana i kā mākou poʻe maʻi i kēlā mau ʻaila, e like me ka aila avocado, ka aila niu, a… ka aila ʻoliva? ʻOliva ʻaila. ʻAe, mahalo iā ʻoe, e Astrid.

 

Kauka Alex Jimenez DC*: He ʻaila ʻoliva kēlā. ʻO Astrid kēlā ma hope. Hoʻopuka maikaʻi mākou i nā ʻike a hoʻomau.

 

Kenna Vaughn: Ke hoʻololi ʻoe i kēlā mau mea, hoʻokaʻawale ʻokoʻa kou kino me kēlā mau momona unsaturated. No laila he koho ʻē aʻe āu i loko o kēlā lumi kuke ma waho o ka hana ʻana i kēlā mau smoothies. Akā e like me kaʻu i ʻōlelo ai ma mua, pili wau i ka wikiwiki, maʻalahi, maʻalahi. ʻOi aku ka maʻalahi o ka hoʻololi ʻana i kou nohona ke loaʻa iā ʻoe kahi hui holoʻokoʻa a puni ʻoe. A i ka maʻalahi, ʻaʻole ʻoe. ʻAʻole ʻoe makemake e hele i waho a paʻakikī i nā mea āpau no ka mea ʻaʻole kiʻekiʻe loa ka manawa e pili ai ʻoe. No laila hoʻokahi mea a mākou e makemake ai e hana, ʻo ia ka maʻalahi o nā mea āpau a mākou e hāʻawi nei i kā mākou poʻe maʻi e hana a hiki ke loaʻa no ke ola o kēlā me kēia lā.

 

Kauka Alex Jimenez DC*: ʻIke loa wau. No laila, ke hele au i ka lumi kuke, makemake au e hoʻohālike i kaʻu kīhini e like me ka cocina a i ʻole nā ​​mea a lākou i kapa ai ma Italia, ʻo ka cucina a he ʻekolu aʻu ʻōmole ma laila, a he ʻaila avocado kaʻu. Loaʻa iaʻu ka ʻaila niu, a loaʻa iaʻu ka ʻaila ʻoliva ma laila. Aia nā ʻōmole nui ma laila. Hana lākou iā lākou nani, a nānā lākou iā Tuscan. A, ʻike ʻoe, ʻaʻohe oʻu manaʻo inā he hua, ʻaʻohe oʻu manaʻo. I kekahi manawa, i ka wā e inu ana au i kaʻu kofe, hopu au i ka ʻaila niu, a ninini au i kēlā i loko a hoʻolilo wau iaʻu iho i java me ka ʻaila niu i loko. No laila, ʻae, hele i mua.

 

Kenna Vaughn: E ʻōlelo ana au he koho maikaʻi loa kēlā. No laila, inu au i ke kī ʻōmaʻomaʻo, a hoʻohui pū wau i ka ʻaila niu i loko o kēlā kī ʻōmaʻomaʻo e kōkua i ka hoʻoikaika ʻana i nā mea āpau a hāʻawi i koʻu kino i kahi maʻi hou o kēlā mau momona momona a mākou e makemake ai.

 

Kauka Alex Jimenez DC*: He nīnau kaʻu iā ʻoe ke loaʻa kāu kofe pēlā; ke loaʻa iā ʻoe ka ʻaila i loko, e ʻano lubricate i kou mau lehelehe.

 

Kenna Vaughn: Hana iki ia. No laila, ua like ia me ka chapstick.

 

Kauka Alex Jimenez DC*: ʻAe, loaʻa. Me he mea lā, ʻŌ, aloha wau. OK, hele i mua.

 

Kenna Vaughn: ʻAe, pono nō hoʻi au e hoʻoulu hou aʻe i mea e maopopo ai ua pololei nā mea a pau. ʻAe. A laila kekahi mea ʻē aʻe e kamaʻilio wale ana i kahi mea e hiki ai i kā mākou poʻe maʻi ke hana i ka wā e hiki mai ai i ka home, aia nā tona o nā koho like ʻole me ka ʻai ʻana i ka iʻa. ʻO ka hoʻonui ʻana i kāu ʻai iʻa maikaʻi i loko o ka pule, e kōkua pū kekahi. A ma muli o ka hāʻawi ʻana o ka iʻa i nā mea nui e like me omegas, ʻike wau iā Astrid kekahi mau ʻike hou aʻe e pili ana i ka omegas.

 

Kauka Alex Jimenez DC*: He nīnau kaʻu ma mua o ko Astrid komo ʻana i laila. Maopopo iā ʻoe, e nānā, ke kamaʻilio mākou e pili ana i ka carbohydrate, ka poʻe, he aha ia ka carbohydrate? ʻAe, ʻōlelo ka poʻe he ʻāpala, ka maiʻa, ka lole lole, a me nā ʻano mea like ʻole e hiki ai i ka poʻe ke hoʻoheheʻe i nā ʻakika a me nā protein. ʻO ka moa, ka ʻiʻo pipi, nā mea a pau e hiki ai ke hoʻoulu. Akā ʻo kekahi o nā mea aʻu i ʻike ai he pilikia ka poʻe me he aha nā momona maikaʻi? Makemake au i ʻelima. E hāʻawi mai iaʻu i ʻumi momona maikaʻi no ka miliona kālā. E hāʻawi mai iaʻu i ʻumi momona maikaʻi e like me ka momona, e like me ka ʻiʻo. ʻAʻole, ʻo kēia kā mākou e kamaʻilio nei. No ka mea, ʻo ka ʻoiaʻiʻo maʻalahi a mākou e hoʻohana ai a e hoʻohui mākou i nā mea ʻino e lilo i ʻaila avocado. ʻOliva ʻaila. He aila niu anei? Hiki iā mākou ke hoʻohana i nā mea e like me ka ʻaila pata, nā ʻano ʻāpana like ʻole, ʻaʻole nā ​​palena, akā nā ʻano pata mai, ʻike ʻoe, nā bipi hānai mauʻu. Hiki iā mākou ke holo i waho o ka creamers, ʻike ʻoe, non-nodairy cream, kikoʻī kikoʻī loa, nā mea a mākou e pau ai, pololei? ʻO ka wikiwiki maoli. No laila, he aha hou ka momona, ʻeā? A laila ʻimi mākou. No laila, ʻo kekahi o nā ala maikaʻi loa e hana ai, ʻaʻole mākou e kau mau i ka creamer ma luna a i ʻole kā mākou pata ma luna, ʻo ia hoʻi, kekahi mau kofe iā lākou, hoʻokomo lākou i ka pata i loko a hui ʻia, a hana lākou. he java liʻiliʻi maikaʻi. A hele mai nā mea a pau me kā lākou liʻiliʻi liʻiliʻi a me kā lākou ʻaila a me kā lākou kofe a hana i ka espresso mai ka lani mai, ʻeā? No laila he aha hou aʻe kā mākou e hana ai?

 

Kenna Vaughn: Hiki iā mākou, e like me kaʻu i ʻōlelo ai, e hoʻohui i kēlā mau iʻa i loko, e kōkua ana i ka hāʻawi ʻana i ko mākou kino i kēlā mau omegas. A laila hiki iā mākou ke hana i nā mea kanu poni hou aʻe, a ʻo ia ka mea e hāʻawi i kou kino i nā antioxidants hou aʻe. No laila he koho maikaʻi kēlā i ka wā e pili ana i ka hale kūʻai. ʻO ke kānāwai o ka manamana nui aʻu i aloha ai a lohe ai i ka wā kahiko, ʻo ka ʻaʻole kūʻai ma nā ʻaoʻao, ʻo ia ka hoʻāʻo e kūʻai ma nā ʻaoʻao no ka mea ʻo nā kihi kahi āu e loaʻa ai nā hua hou a me nā ʻiʻo wīwī āpau. ʻO ia ka wā e hoʻomaka ai ʻoe e komo i loko o kēlā mau aisles, a ma laila ʻoe e hoʻomaka ai e ʻimi, ʻike ʻoe, ʻo ka cereal, kēlā mau carbohydrate maikaʻi ʻole, kēlā mau carbohydrates maʻalahi i makemake ʻia e ka ʻai ʻAmelika akā ʻaʻole pono. ʻO nā Oreos?

 

Kenna Vaughn: ʻAe.

 

Kauka Alex Jimenez DC*: ʻO ka aisle candy i ʻike ʻia e kēlā me kēia keiki. ʻAe, ʻae. 

 

Kenna Vaughn: No laila, ʻo ia kahi mea nui ma laila. No laila ke hele mai nei ʻoe i kā mākou keʻena, inā e loaʻa ana ʻoe i ka metabolic syndrome a i ʻole kekahi mea maʻamau, hana mākou i kāu mau hoʻolālā pilikino a hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo he nui. Hoʻolohe mākou i kou nohona no ka mea ʻaʻole pono ka mea e hana ai no kekahi. No laila ke hōʻoia nei mākou e hāʻawi mākou iā ʻoe i ka ʻike a mākou e ʻike e kūleʻa ana ʻoe a hāʻawi i ka hoʻonaʻauao no ka mea ʻo ia kekahi hapa nui o ia mea.

 

Kauka Alex Jimenez DC*: Aia nā alanui a pau i ka lumi kuke, ʻeā? Akau? ʻAe, hana lākou. ʻAe, no laila e hoʻonui pololei i ka momona a me ka nutraceuticals. Makemake wau e hāʻawi iā ʻoe i kahi manaʻo e pili ana i ke ʻano o ka nutraceuticals i kūpono iā mākou no ka mea makemake mākou e hoʻopau i kēia mau pilikia ʻelima e pili ana i ka metabolic syndrome a mākou i kūkākūkā ai. He aha nā kāne ʻelima? E hele kākou a hoʻomaka iā lākou. He koko koko kiʻekiʻe, ʻeā?

 

Kenna Vaughn: ʻO ka glucose koko kiʻekiʻe, nā HDL haʻahaʻa, ʻo ia ka cholesterol maikaʻi e pono ai nā mea a pau. Ae. A e lilo ana ia i ke koko kiʻekiʻe, ʻaʻole i manaʻo ʻia he kiʻekiʻe mai ke kūlana o ke kauka, akā manaʻo ʻia he kiʻekiʻe. No laila he mea ʻē aʻe; makemake mākou e hōʻoia he metabolic syndrome kēia, ʻaʻole he maʻi metabolic. No laila, inā hele ʻoe i ke kauka a ʻoi aku ka 130 o ke kahe koko ma mua o kanawalukūmālima, he hōʻailona ia. Akā naʻe, ʻaʻole ʻōlelo paha kāu mea lawelawe i ke kiʻekiʻe o ke kahe koko. 

 

Kauka Alex Jimenez DC*: ʻAʻohe o kēia mau maʻi ma ʻaneʻi he mau mokuʻāina lapaʻau, a ʻo kēlā me kēia, he mau mea wale nō lākou. Akā inā hoʻohui ʻoe i kēia mau ʻelima, loaʻa iā ʻoe ka metabolic syndrome a manaʻo ʻoe ʻaʻole maikaʻi loa, ʻaʻole?

 

ʻO Astrid Ornelas: ʻAe, ʻae.

 

Kenna Vaughn: ʻO kekahi ʻē aʻe ʻo ia ke kaumaha nui a puni ka ʻōpū a me nā triglycerides kiʻekiʻe.

 

Kauka Alex Jimenez DC*: Maʻalahi ke ʻike. Hiki iā ʻoe ke ʻike i ka wā e kau ana ka ʻōpū o kekahi e like me ka pūnāwai, ʻeā? No laila hiki iā mākou ke ʻike hiki iā ʻoe ke hele i kekahi manawa i nā hale ʻaina Italia a ʻike i ke kuke nui. A ʻo ia i kekahi manawa e haʻi aku wau iā ʻoe, i kekahi manawa wale nō, ʻike ʻoe, ua kamaʻilio mākou me Chef Boyardee ʻaʻole ia he kanaka wiwi. Manaʻo wau ʻo Chef Boyardee, ʻike ʻoe he aha? A ʻo ke kanaka Pillsbury, ʻeā? ʻAe, ʻaʻole maikaʻi loa ia, ʻeā? Ua pilikia lāua ʻelua i ka metabolic syndrome mai ka hoʻomaka ʻana. No laila he mea maʻalahi ke ʻike. No laila eia nā mea a mākou e noʻonoʻo ai. E hele ana ʻo Astrid ma luna o kekahi mau nutraceuticals, vitamina, a me kekahi mau meaʻai e hiki ai iā mākou ke hoʻomaikaʻi i nā mea. No laila eia ʻo Astrid, a eia kā mākou mea mālama ʻepekema. Akā eia ʻo Astrid, e hele i mua.

 

ʻO Astrid Ornelas: ʻAe, manaʻo wau ma mua o ko mākou komo ʻana i ka nutraceuticals, makemake wau e wehewehe i kekahi mea. E like me kā mākou e kamaʻilio nei e pili ana i ka metabolic syndrome. ʻAʻole ʻo Metabolic Syndrome he, a ke manaʻo nei au he maʻi a i ʻole ka pilikia olakino. ʻO ka Metabolic Syndrome kahi puʻupuʻu o nā kūlana e hiki ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā pilikia olakino e like me ka maʻi diabetes, ka hahau ʻana, a me ka maʻi puʻuwai. No ka mea, ʻaʻole ʻo metabolic syndrome, ʻike ʻoe, he pilikia olakino maoli, ʻoi aku ka nui o kēia pūʻulu, kēia hōʻiliʻili o nā kūlana ʻē aʻe, nā pilikia ʻē aʻe e hiki ke ulu i nā pilikia olakino. Ma muli wale nō o kēlā ʻoiaʻiʻo, ʻaʻohe hōʻailona ʻike ʻia o ka metabolic syndrome. Akā ʻoiaʻiʻo, e like me kā mākou e kamaʻilio nei, ʻelima mau kumu pilikia ka mea a mākou i kamaʻilio ai: ʻoi aku ka momona o ka pūhaka, ke koko kiʻekiʻe, ke koko koko kiʻekiʻe, ka triglycerides kiʻekiʻe, ka haʻahaʻa HDL, a e like me ka ʻoihana mālama olakino. I nā kauka a me nā mea noiʻi, ʻike ʻoe he metabolic syndrome kāu inā loaʻa iā ʻoe ʻekolu o kēia mau mea pilikia ʻelima.

 

Kauka Alex Jimenez DC*: Ae. Ekolu. I kēia manawa, ʻaʻole ia he manaʻo inā loaʻa iā ʻoe, loaʻa iā ʻoe nā hōʻailona. E like me kaʻu e ʻike ai ua ʻike ʻia ma. Akā, pono wau e haʻi iā ʻoe i koʻu ʻike inā ʻoi aku ka nui o kekahi ma mua o ʻekolu a ʻekolu paha. Ke hoʻomaka nei lākou e ʻeha. ʻAʻole maikaʻi ko lākou manaʻo. Manaʻo wale lākou, ʻike ʻoe, ʻaʻole maikaʻi ke ola. Loaʻa iā lākou kahi holoʻokoʻa. ʻAʻole lākou nānā pono. No laila ʻaʻole wau ʻike iā lākou, malia paha. Akā ʻike ko lākou ʻohana ʻaʻole maikaʻi lākou. Me he mea lā ʻaʻole maikaʻi ko mama. Maikaʻi ko Pāpā.

 

ʻO Astrid Ornelas: ʻAe, ʻae. A me ka metabolic syndrome, e like me kaʻu i ʻōlelo ai, ʻaʻohe ona hōʻailona ʻike. Akā, ʻike ʻoe, ua ʻano hele au me kekahi o nā kumu pilikia me ka momona pūhaka, a ma laila ʻoe e ʻike ai i ka poʻe me ka mea āu i kapa ai he kino ʻāpala a i ʻole ke kino pear, no laila ua nui ka momona a puni ko lākou ʻōpū. A ʻoiai ʻaʻole ia i manaʻo ʻia he hōʻailona, ​​​​he mea ia e hiki ai; Manaʻo wau hiki iā ia ke hāʻawi i ka manaʻo i nā kauka a i ʻole nā ​​mea mālama ola kino ʻē aʻe i kēia kanaka, ʻike ʻoe, he prediabetes a he maʻi diabetes paha. A, ʻike ʻoe, ua nui ko lākou kaumaha a me ka momona. Hiki iā lākou ke piʻi aʻe ka pilikia o ka metabolic syndrome a no laila ke ulu nei, ʻike ʻoe, inā ʻaʻole mālama ʻia, e ulu ana i nā pilikia olakino e like me ka maʻi puʻuwai a me ka hahau. Manaʻo wau me kēlā ʻōlelo ʻia; a laila e komo mākou i ka nutraceutical.

 

Kauka Alex Jimenez DC*: Aloha wau i kēia, aloha wau i kēia. Loaʻa iā mākou kekahi mau mea maikaʻi, a loaʻa iā mākou kekahi ʻike.

 

ʻO Astrid Ornelas: A manaʻo wau me kēlā ʻōlelo ʻana, e komo mākou i ka nutraceuticals. ʻAno like, pehea ʻo Kenna i kamaʻilio ai e pili ana i ka mea lawe? ʻIke ʻoe, ke kamaʻilio nei mākou no kēia mau pilikia olakino, a ke kamaʻilio nei mākou e pili ana i ka metabolic syndrome i kēia lā. Akā he aha ka mea lawe? He aha kā mākou e haʻi aku ai i nā kānaka? He aha kā lākou e lawe ai no kā mākou kamaʻilio ʻana? He aha kā lākou e hana ai ma ka home? No laila, eia mākou he mau nutraceuticals, aʻu i kākau ai i kekahi mau ʻatikala ma kā mākou blog a nānā. 

 

Kauka Alex Jimenez DC*:  Manaʻo ʻoe, ʻo Astrid? Inā ʻoe e nānā i nā ʻatikala 100 i kākau ʻia ma El Paso, ma ka liʻiliʻi ma ko mākou wahi, ua hoʻoponopono ʻia lākou a pau e kekahi. Ae. Mea pono nui.

 

ʻO Astrid Ornelas: Ae. No laila, loaʻa iā mākou kekahi mau nutraceuticals ma ʻaneʻi i noiʻi ʻia. Ua heluhelu nā mea noiʻi i kēia mau noiʻi noiʻi āpau a ʻike hiki iā lākou ke kōkua ma kekahi ʻano a hoʻomaikaʻi kekahi ʻano, ʻike ʻoe, metabolic syndrome a me kēia mau maʻi pili. No laila ʻo ka mea mua aʻu e makemake ai e kūkākūkā i nā huaora B. No laila he aha nā huaora B? ʻO kēia nā mea āu e loaʻa pinepine ai iā lākou pū kekahi. Hiki iā ʻoe ke loaʻa iā lākou ma ka hale kūʻai. E ʻike ʻoe iā lākou he mau huaora B-complex. E ʻike ʻoe e like me kahi hue liʻiliʻi, a laila hele mai me ka nui o nā huaora B. I kēia manawa, no ke aha wau e lawe ai i nā huaora B no ka metabolic syndrome? No laila ua ʻike kekahi o nā kumu e like me nā mea noiʻi ʻo kekahi o lākou, manaʻo wau, ʻo kekahi o nā kumu o ka metabolic syndrome hiki ke koʻikoʻi. No laila me kēlā ʻōlelo ʻana, pono mākou e loaʻa i nā huaora B no ka mea ke pilikia mākou i ka wā paʻakikī i ka hana ke loaʻa iā mākou, manaʻo wau he nui ka poʻe i ʻike, nui nā mea koʻikoʻi ma ka home a me ka ʻohana, ko mākou hopohopo. E hoʻohana ka ʻōnaehana i kēia mau huaora B e kākoʻo i kā mākou hana aʻalolo. No laila ke pilikia nui mākou, e hoʻohana mākou i kēia mau huaora, kahi e hoʻonui ai i ke kaumaha; ʻike ʻoe, e hana ko mākou kino i cortisol. ʻIke ʻoe, e lawelawe ana i kahi hana. Akā ʻike mākou a pau i ka nui o ka cortisol, hiki i ke koʻikoʻi nui loa. Hiki ke pōʻino iā mākou. Hiki iā ia ke hoʻonui i ko mākou pilikia i ka maʻi puʻuwai.

 

Kauka Alex Jimenez DC*: ʻIke ʻoe, e like me kaʻu e hoʻomanaʻo nei i kā mākou hana ʻana i kēia, hele nā ​​​​alanui a pau i ka lumi kuke no ka hoʻihoʻi ʻana i ka meaʻai i loko o kou kino. ʻO nā alanui āpau e alakaʻi i ka mitochondria i ka wā e hiki mai ai i kahi o ka haki. Hoʻopuni ʻia ka honua o ka hana ikehu ATP me ka nicotinamide, NADH, HDP, ATPS, ADP. He pilina kēia mau mea a pau me ka huaora B o nā ʻano a pau. No laila, aia nā huaora B i ka ʻenekini i ka turbine o nā mea kōkua iā mākou. No laila he mea kūpono kēia ʻo ka luna o ka huaora a ʻo ka mea nui loa. A laila loaʻa iā ia kekahi mau mea hope ʻē aʻe ma niacin. He aha ka niacin? He aha kāu i ʻike ai ma laila?

 

ʻO Astrid Ornelas: ʻAe, ʻo niacin kahi huaʻa B ʻē aʻe, ʻike ʻoe, aia kekahi mau huaora B. ʻO ia ke kumu i loaʻa iaʻu ma lalo o kāna plural a me ka niacin a i ʻole ka huaora B3, e like me ka mea i ʻike nui ʻia. He nui ka poe akamai. Nui nā noiʻi noiʻi i ʻike ʻo ka lawe ʻana i ka huaora B3 hiki ke kōkua i ka hoʻohaʻahaʻa ʻana i ka LDL a i ʻole ka cholesterol maikaʻi ʻole, kōkua i ka hoʻohaʻahaʻa i nā triglycerides, a me ka hoʻonui ʻana i ka HDL. A ua ʻike kekahi mau noiʻi noiʻi ʻo ka niacin, ʻo ia hoʻi ka huaora B3, hiki ke kōkua i ka hoʻonui ʻana i ka HDL ma 30 pakeneka.

 

Kauka Alex Jimenez DC*: Kupanaha. Ke nānā ʻoe iā NADP a me NADH, ʻo ia ka N ka niacin, ka nicotinamide. No laila, i loko o ka pūhui biochemical, ʻo ka niacin ka mea i ʻike ʻia e ka poʻe i ka wā e lawe ai ʻoe i ka mea maikaʻi a i ʻole ka mea i manaʻo ʻia, loaʻa iā ʻoe kēia manaʻo ʻulaʻula a hana ʻoe iā ʻoe e ʻoki i kou ʻāpana āpau o kou kino, a manaʻo ia. maikaʻi ke ʻakaʻaka ʻoe no ka mea e manaʻo ʻoe pēlā. Pololei, nani loa. A nui kēia.

 

ʻO Astrid Ornelas: Ae. ʻAe, a ʻo ia hoʻi, makemake wau e hōʻike i kahi kikoʻī e pili ana i nā huaora B. Pono nā huaora B no ka mea hiki iā lākou ke kōkua i ke kākoʻo ʻana i kā mākou metabolism i ka wā e ʻai ai mākou, ʻike ʻoe, nā carbohydrates a me nā momona, nā momona maikaʻi, ʻoiaʻiʻo, a me nā protein. Ke hele nei ke kino i ke kaʻina hana metabolism, hoʻololi ia i kēia mau kalapona, momona, a me ka protein. Hoʻololi nā protein i ka ikehu, a ʻo nā huaora B nā mea nui e mālama i ka hana ʻana.

 

Kauka Alex Jimenez DC*: ʻO nā Latinos, i ko mākou heluna lehulehu, ʻike mākou ua lohe mau mākou i ke kahu hānai a i ʻole ke kanaka nāna i hāʻawi i ka lāʻau ʻaila B. No laila ua lohe ʻoe i kēlā mau mea. Akau. No kou kaumaha, kaumaha ʻoe, he aha kā lākou e hana ai? ʻAe, ʻike ʻoe i ka mea e hoʻokomo iā lākou me B12, pololei? ʻO wai nā huaora B, pololei? A puka mai ke kanaka me he mea lā, ʻAe, a hauʻoli lākou, ʻeā? No laila ua ʻike mākou i kēia, a ʻo ia ka elixir o ka wā i hala. ʻO kēlā poʻe mea kūʻai huakaʻi hele, nona nā lāʻau ʻala a me nā lotions, ua ola lākou i ka hāʻawi ʻana i ka paʻakikī huaʻai B. Ua hoʻolālā mua ʻia nā mea inu ikaika mua me kahi paʻakikī B, ʻike ʻoe, e hoʻopili ana iā lākou. Eia ka hana. I kēia manawa ua aʻo mākou ʻo nā mea inu ikaika ke kumu i nā pilikia he nui, ke hoʻi nei mākou i nā paʻina B e kōkua maikaʻi i nā poʻe. No laila, ʻo ka huaʻaola e loaʻa iā mākou ma laila ʻo ia ka mea i loaʻa iā mākou ka D, loaʻa iā mākou ka vitamina D.

 

ʻO Astrid Ornelas: ʻAe, ʻo ka mea hou aʻe aʻu i makemake ai e kamaʻilio e pili ana i ka huaora D. No laila he nui nā noiʻi noiʻi e pili ana i ka huaora D a me nā pōmaikaʻi, nā pōmaikaʻi o ka vitamina D no ka metabolic syndrome, a pehea wau i kūkākūkā ai pehea e pono ai nā huaora B no kā mākou metabolism. He mea kōkua pū ka Vitamin D no kā mākou metabolism, a hiki ke kōkua i ka hoʻoponopono ʻana i ko mākou koko koko, ʻo ia hoʻi ko mākou glucose. A he mea nui loa ia no ka mea, e like me kekahi o nā mea predisposing o ka metabolic syndrome, ke koko koko kiʻekiʻe. A ʻike ʻoe, inā loaʻa iā ʻoe ke kō koko kiʻekiʻe ʻole, hiki ke alakaʻi i, ʻike ʻoe, hiki ke alakaʻi i ka prediabetes. A inā ʻaʻole mālama ʻia kēlā, hiki ke alakaʻi i ka maʻi diabetes. No laila ua ʻike ʻia nā noiʻi noiʻi hiki i ka vitamina D ponoʻī ke hoʻomaikaʻi i ka pale ʻana i ka insulin, ʻo ia ka mea e hiki ke alakaʻi i ka maʻi diabetes.

 

Kauka Alex Jimenez DC*:  ʻIke ʻoe, makemake wale au e hoʻopau i ka huaora D ʻaʻole ia he huaʻai; he hormone. Ua ʻike ʻia ma hope o C e Linus Pauling. I ka loaʻa ʻana, hoʻomau lākou i ka inoa o kēia leka. ʻAe, no ka mea he hormone ia, pono ʻoe e nānā iā ia. ʻO kēia vitamin D a i ʻole kēia hormone tocopherol. Hiki iā ia ke hoʻololi i nā pilikia metabolism i loko o kou kino. Ke kamaʻilio nei au e pili ana i ʻehā a ʻelima haneli kaʻina hana like ʻole a mākou e ʻike nei. ʻO ka makahiki i hala he 400. Ua kokoke mākou i kēia manawa ma kahi o 500 mau kaʻina biochemical ʻē aʻe i hoʻopili pololei ʻia. ʻAe, he ʻano manaʻo. E nānā, ʻo ko mākou kino koʻikoʻi i loko o ke kino ko mākou ʻili, a ʻo ka hapa nui o ka manawa, holo mākou a puni i kekahi ʻano lole liʻiliʻi, a nui mākou i ka lā. ʻAe, ʻaʻole mākou i kū i ka noʻonoʻo ʻana e hiki i kēlā ʻano kino ke hana i ka nui o ka ikaika ho'ōla, a hana ʻo vitamin D i kēlā. Hana ʻia ia e ka lā a hoʻāla ʻia. Akā ʻo ka honua o kēia lā, inā he Armenian mākou, Iranian, nā moʻomeheu like ʻole ma ke kūkulu ʻākau, e like me Chicago, ʻaʻole loaʻa i nā kānaka ka mālamalama. No laila, ma muli o nā loli moʻomeheu a me nā poʻe pani e noho ana a e hana ana i kēia mau kukui fluorescent, nalowale mākou i ke ʻano o ka huaora D a loaʻa i ka maʻi nui. ʻOi aku ka maikaʻi o ke olakino o ka mea nāna e lawe i ka huaora D, a ʻo kā mākou pahuhopu ʻo ka hoʻonui ʻana i ka vitamina D he mea hiki ke hoʻoheheʻe ʻia i ka momona a hoʻokomo ʻia iā ia iho a mālama ʻia i loko o ke ake me ka momona o ke kino. No laila hiki iā ʻoe ke hoʻokiʻekiʻe lohi i kou lawe ʻana, a paʻakikī ka loaʻa ʻana o nā pae ʻona, akā aia kēlā mau mea ma kahi o hoʻokahi haneli iwakāluakūmālima nanograms no ka deciliter i kiʻekiʻe loa. Akā ʻo ka hapa nui o mākou e holo a puni me 10 a 20, ʻo ia ka haʻahaʻa. No laila, ʻo ka mea nui, ma ka hoʻāla ʻana i kēlā, e ʻike ʻoe e hoʻololi ʻia ke koko koko e hiki mai ana a Astrid e ʻōlelo nei. He aha nā mea a mākou e ʻike ai, ʻoi aku ka nui o ka vitamin D? ʻO kekahi mea?

 

ʻO Astrid Ornelas: ʻO koʻu manaʻo, e hoʻi hou wau i ka vitamina D i kekahi manawa; Makemake au e kūkākūkā mua i kekahi o nā nutraceuticals. OK. Akā, ʻoi aku ka maikaʻi o ka vitamina D no ka mea kōkua ia i ka hoʻomaikaʻi ʻana i kāu metabolism, a kōkua ia i ka hoʻomaikaʻi ʻana i kou kūpaʻa insulin, ma ka liʻiliʻi loa i ka metabolic syndrome.

 

Kauka Alex Jimenez DC*: Pehea ka calcium?

 

ʻO Astrid Ornelas: No laila hele pū ka calcium me ka huaora D, a me ka mea aʻu i makemake ai e kamaʻilio pū me ka vitamina D a me ka calcium. Manaʻo pinepine mākou e pili ana i kēia mau mea ʻelima a mākou i ʻōlelo ai ma mua e hiki ke hoʻoulu i kahi metabolic syndrome. Eia nō naʻe, ʻike ʻoe, inā makemake ʻoe e noʻonoʻo e pili ana iā ia, e like me ke kumu kumu o ka nui o kēia mau mea pilikia? A e like me, ʻike ʻoe, ka momona, ka noho maʻamau, ka poʻe i komo ʻole i ka hoʻoikaika kino a i ʻole ka hana kino. ʻO kekahi o nā mea e hiki ke predispose i ke kanaka a i ʻole e hoʻonui i ko lākou pilikia o ka metabolic syndrome. E hoʻokomo wau i ke ʻano. He aha inā he maʻi ʻeha mau ke kanaka? He aha inā loaʻa iā lākou kekahi mea e like me ka fibromyalgia? Ua ʻeha mau lākou. ʻAʻole lākou makemake e neʻe, no laila ʻaʻole lākou makemake e hoʻoikaika kino. ʻAʻole lākou makemake e hoʻonui i kēia mau hōʻailona. I kekahi manawa, loaʻa i kekahi poʻe ka ʻeha mau a i ʻole nā ​​mea like me ka fibromyalgia. E hele kāua i kahi mea maʻamau. Loaʻa i kekahi poʻe ka ʻeha hope mau loa, a ʻaʻole makemake ʻoe e hana. No laila ʻaʻole ʻoe e koho e like me ke koho ʻole ʻana o kekahi o kēia poʻe no ka mea makemake lākou. Aia kekahi o kēia poʻe i ka ʻeha, a he nui nā noiʻi noiʻi, a ʻo ia kaʻu e hoʻopaʻa ai i ka vitamina D a me ka calcium me kēlā vitamina D a me ka calcium. ʻIke ʻoe, hiki iā mākou ke lawe pū iā lākou. Hiki iā lākou ke kōkua i ka hoʻomaikaʻi ʻana i ka ʻeha mau i kekahi poʻe.

 

Kauka Alex Jimenez DC*: Kupanaha. A ʻike mākou a pau ʻo ka calcium kekahi o nā kumu o ka ʻiʻo spasms a me nā mea hoʻomaha. ʻO nā kumu kumu. E hele mākou i kēlā me kēia o kēia. E loaʻa iā mākou kahi podcast ma ka vitamina D wale nō a me nā pilikia i ka calcium no ka mea hiki iā mākou ke hele hohonu. E hele ana mākou i ka hohonu, a e hele mākou i ke ala āpau i ka genome. ʻO ka genome ka genomics, ʻo ia ka ʻepekema o ka hoʻomaopopo ʻana i ke ʻano o ka hula ʻana o ka meaʻai a me nā genes. No laila, e hele ana mākou i laila, akā, ua like mākou me ke komo mālie i kēia kaʻina hana no ka mea pono mākou e lawe mālie i ka moʻolelo. He aha ka mea e hiki mai ana?

 

ʻO Astrid Ornelas: No laila aʻe, loaʻa iā mākou nā omega 3, a makemake wau e hōʻike kikoʻī ke kamaʻilio nei mākou e pili ana i nā omega 3 me EPA, ʻaʻole DHA. No laila ʻo EPA kēia, ʻo ia ka mea i helu ʻia ma laila, a me DHA. ʻElua mau ʻano koʻikoʻi o ka omega 3s. ʻO ka mea nui, he mea koʻikoʻi lāua ʻelua, akā he nui nā noiʻi noiʻi a ua hana wau i nā ʻatikala e pili ana i kēia a ua ʻike wau i ka lawe ʻana i ka omega 3 me EPA, ʻoi aku ka maikaʻi o kāna mau pono ma mua o DHA. A ke kamaʻilio mākou e pili ana i ka omega 3s, hiki ke loaʻa i kēia mau iʻa. ʻO ka hapa nui o ka manawa, makemake ʻoe e lawe i nā omega 3; ʻike ʻoe iā lākou ma ke ʻano o ka ʻaila iʻa. A ke hoʻi nei kēia i ka mea a Kenna i kūkākūkā ai ma mua, e like me ka hahai ʻana i ka meaʻai Mediterranean, ka mea nui i ka ʻai ʻana i ka iʻa he nui. Ma laila ʻoe e ʻai ai i ka omega 3s, a ua ʻike nā noiʻi noiʻi hiki i nā omega 3 iā lākou iho ke kōkua i ka hoʻoikaika ʻana i ke olakino puʻuwai, a hiki iā lākou ke kōkua i ka hoʻohaʻahaʻa ʻana i ka cholesterol maikaʻi ʻole i kāu LDL. A hiki i kēia mau mea ke hoʻomaikaʻi i kā mākou metabolism, e like me ka vitamin D.

 

Kauka Alex Jimenez DC*: Makemake mākou e hele i mua a uhi i kēia mau mea āpau ma lalo o ka ʻoiaʻiʻo a mākou e nānā nei, a ke hana nei mākou i ka metabolic syndrome, ke hana nei mākou me ka mumū. Ua ʻike ʻia ka mumū a me ka omegas. No laila ʻo ka mea e pono ai mākou e hana, ʻo ia ka hoʻopuka ʻana i ka ʻoiaʻiʻo o ka omegas i loko o ka ʻai ʻAmelika, ʻoiai i ka ʻai a ke kupuna wahine. A laila, e like me hou, lohe mākou i ka lā i hāʻawi aku ai ke kupunawahine a i ʻole ke kupuna wahine iā ʻoe i ka ʻaila ate cod. ʻAe, ʻo ka iʻa lawe omega kiʻekiʻe ʻo ia ka herring, aia ma kahi o 800 milligrams i kēlā me kēia lawelawe. Aia ka cod ma kahi o 600. Akā no ka loaʻa ʻana, ʻoi aku ka nui o ke kāleka i kekahi mau moʻomeheu. No laila e loa'a i nā kānaka a pau ka aila ate cod, a ho'opa'a lākou i kou ihu a inu, a 'ike lākou ua pili ia. Manaʻo lākou he lubricant maikaʻi. Eia nō naʻe, he anti-inflammatory ia me ka poʻe, a ʻo ka mea maʻamau, ʻo nā kupuna wahine i ʻike i kēia pono ke kōkua i ka ʻōpū, kōkua i ka ʻā, kōkua i nā hono. Ua ʻike lākou i ka moʻolelo holoʻokoʻa ma hope o kēlā. No laila e hele hohonu mākou i ka Omegas i kā mākou podcast hope. Loaʻa iā mākou kekahi ma ʻaneʻi. Kapa ʻia ʻo ia he berberine, ʻeā? He aha ka moʻolelo ma ka berberine?

 

ʻO Astrid Ornelas: ʻAe, ʻoi aku ka maikaʻi o ka hoʻonohonoho hou o nā nutraceuticals i helu ʻia ma aneʻi, berberine, glucosamine, chondroitin, acetyl L-carnitine, alpha-lipoic acid, ashwagandha, ʻoi aku ka nui o kēia mau mea i hoʻopaʻa ʻia i ka mea aʻu i kamaʻilio ai ma mua e pili ana i ka ʻeha mau a me nā mea āpau. o keia mau pilikia ola kino. Ua papa inoa au iā lākou ma ʻaneʻi no ka mea ua hana au i kekahi mau ʻatikala. Ua heluhelu au i nā noiʻi noiʻi like ʻole i uhi i kēia ma nā hoʻokolohua like ʻole a ma nā noiʻi noiʻi lehulehu me nā mea komo he nui. A ua loaʻa nui kēia mau mea, ʻike ʻoe, kēia hui o nā nutraceuticals ma aneʻi i helu ʻia; ua hoʻopaʻa ʻia kēia mau mea i mea e hoʻemi ai i ka ʻeha mau loa. ʻIke ʻoe, a e like me kaʻu i kūkākūkā ai ma mua, e like me ka ʻeha mau loa, ʻike ʻoe, ka poʻe i loaʻa i ka fibromyalgia a i ʻole like paha, ʻike ʻoe, e hele maʻalahi kākou i ka poʻe e loaʻa ana i ka ʻeha hope, ʻike ʻoe, ʻo kēia poʻe hana ʻole i loaʻa ka noho maʻamau. ma muli o ko lākou ʻeha a hiki iā lākou ke pilikia i ka metabolic syndrome. ʻO ka nui o kēia mau noiʻi noiʻi ua ʻike i kēia mau nutraceutical iā lākou iho hiki ke kōkua i ka hōʻemi ʻana i ka ʻeha mau.

 

Kauka Alex Jimenez DC*: Manaʻo wau ua kapa ʻia ka mea hou i ka alpha-lipoic acid. ʻIke wau i ka acetyl L-carnitine. E loaʻa iā mākou ko mākou biochemist kamaʻāina ma ka podcast aʻe e hele hohonu i kēia. He inoa hoihoi ʻo Ashwagandha. Ashwagandha. E hai mai. E hana hou. Kenna, hiki iā ʻoe ke haʻi iki iaʻu e pili ana i ka ashwagandha a me ka mea a mākou i ʻike ai e pili ana i ka ashwagandha? No ka mea he inoa kū hoʻokahi a me kahi ʻāpana a mākou e nānā ai, e kamaʻilio hou mākou e pili ana. E hoʻi mākou i Astrid i kekona, akā e hāʻawi wau iā ia i kahi hoʻomaha iki a me ke ʻano like, e haʻi mai ʻo Kenna iaʻu i kahi ashwagandha.

 

Kenna Vaughn: E hoʻohui wau i kekahi mea e pili ana i kēlā berberine.

 

Kauka Alex Jimenez DC*: ʻAe, e hoʻi kāua i ka berberine. ʻO kēia ka berberine a me ka ashwagandha.

 

Kenna Vaughn: ʻAe, no laila ua hōʻike ʻia ka berberine e kōkua i ka hoʻohaʻahaʻa ʻana i ka HB A1C i nā poʻe maʻi me ka dysregulation koko koko, e hoʻi hou i ka prediabetes holoʻokoʻa a me nā kūlana maʻi diabetes ʻelua e hiki ke hana i loko o ke kino. No laila ua hōʻike ʻia ka hoʻemi ʻana i kēlā helu e hoʻopaʻa i ke kō koko.

 

Kauka Alex Jimenez DC*:  Aia kahi mea āpau e loaʻa iā mākou ma ka berberine. Akā ʻo kekahi o nā mea a mākou i hana ai e pili ana i ka metabolic syndrome i hana maoli i ka papa inoa kiʻekiʻe ma aneʻi no ke kaʻina hana. No laila aia ka ashwagandha a me ka berberine. No laila e haʻi mai iā mākou a pau e pili ana i ka ashwagandha. Eia kekahi, ʻo ashwagandha ka mea. No laila ma ke ʻano o ke kō koko, ʻo ka A1C ka helu koko koko e haʻi pololei iā ʻoe i ka hana a ke kō koko ma kahi o ʻekolu mahina. Hiki ke ana ʻia ka glycosylation o ka hemoglobin e nā hoʻololi molekula i hana ʻia i loko o ka hemoglobin. ʻO ia ke kumu ʻo ka Hemoglobin A1C kā mākou māka e hoʻoholo ai. No laila ke hui pū ʻo ashwagandha a me berberine a hoʻohana i kēlā mau mea, hiki iā mākou ke hoʻololi i ka A1C, ʻo ia ka ʻano ʻekolu mahina e like me ka moʻolelo o ka mea e hana nei. Ua ʻike mākou i nā loli i kēlā. A ʻo ia kekahi o nā mea a mākou e hana ai i kēia manawa e pili ana i nā dosages a me nā mea a mākou e hana ai. E hele ana mākou i kēlā, akā ʻaʻole i kēia lā no ka mea ʻoi aku ka paʻakikī. ʻO nā fibers soluble kekahi mea o nā mea. No laila, i ka wā e hana ai mākou i nā fiber soluble, no ke aha mākou e kamaʻilio nei e pili ana i nā fiber soluble? ʻO ka mea mua, he meaʻai ia no kā mākou mau pōpoki, no laila pono mākou e hoʻomanaʻo ʻo ka honua probiotic kahi mea hiki ʻole iā mākou ke poina. Pono ka poʻe e hoʻomaopopo i kēlā probiotics, inā ʻo ia ka Lactobacillus a i ʻole Bifidobacterium strains, inā he ʻōpū liʻiliʻi, ʻōpū nui, ma mua o ka ʻōpū liʻiliʻi, aia nā bacteria ʻokoʻa a hiki i ka hopena e ʻike i ka hiki ʻana mai i ka hope hope. No laila e kapa ʻia ʻo ia kahi e puka mai ai nā mea. Aia nā bacteria ma nā wahi like ʻole ma nā pae like ʻole, a he kumu ko kēlā me kēia e ʻike ai. Aia ka huaora E a me ke kī ʻōmaʻomaʻo. No laila e haʻi mai iaʻu, e Astrid, e pili ana i kēia mau dynamics e pili ana i ke kī ʻōmaʻomaʻo. He aha kā mākou e ʻike ai e pili ana i ka metabolic syndrome?

 

ʻO Astrid Ornelas: OK. No laila he nui nā pōmaikaʻi o ke kī ʻōmaʻomaʻo, ʻike ʻoe? Akā, ʻike ʻoe, ʻaʻole makemake kekahi poʻe i ke kī, a ʻoi aku ka makemake o kekahi i ke kofe, ʻike ʻoe? Akā inā makemake ʻoe e komo i ka inu kī, ʻike ʻoe, ʻoiaʻiʻo ma muli o kāna mau pono olakino. He wahi maikaʻi ke kī ʻōmaʻomaʻo e hoʻomaka ai a ma ke ʻano o ka metabolic syndrome. Ua hōʻike ʻia ke kī ʻōmaʻomaʻo e kōkua i ka hoʻomaikaʻi ʻana i ke olakino puʻuwai, a hiki ke kōkua i ka hoʻohaʻahaʻa ʻana i kēia mau mea pilikia e pili ana i ka metabolic syndrome. Hiki iā ia ke kōkua, ʻike ʻoe, he mau noiʻi noiʻi i ʻike e hiki i ke kī ʻōmaʻomaʻo ke kōkua i ka hoʻohaʻahaʻa ʻana i ka cholesterol, ka cholesterol maikaʻi ʻole, nā LDLs.

 

Kauka Alex Jimenez DC*: Kōkua anei ke kī ʻōmaʻomaʻo iā mākou i ka momona o ka ʻōpū?

 

ʻO Astrid Ornelas: ʻAe. Aia kekahi o nā pono o ke kī ʻōmaʻomaʻo aʻu i heluhelu ai. ʻO kekahi o nā mea i ʻike nui ʻia ʻo ia ka hiki ke kōkua i ke kī ʻōmaʻomaʻo i ka pohō kaumaha.

 

Kauka Alex Jimenez DC*: Auwe kuu akua. No laila, ʻo ka wai a me ke kī ʻōmaʻomaʻo. ʻO ia, e nā kāne. O ia wale nō. Hoʻopau mākou i ko mākou ola, ʻo ia hoʻi, ua poina mākou i ka mea ikaika loa. Mālama ʻo ia i kēlā mau ROS, he ʻano oxygen reactive, kā mākou antioxidants, a i ʻole oxidants i loko o ko mākou koko. No laila e hoʻokuʻu wale iā lākou a lawe iā lākou i waho a hoʻomaha i ko lākou ʻoluʻolu a pale aku i ka pōʻino maʻamau e kū mai ana a i ʻole ka hōʻino nui ʻana i ka haki ʻana o ka metabolism maʻamau, ʻo ia ka hopena o ROS. oxidants, he inoa maʻemaʻe kā mākou no nā mea e ʻoki ai iā lākou a hoʻomaha iā lākou a kau iā lākou i ke ʻano a lākou i kapa ai he antioxidants. No laila, ʻo nā huaora he antioxidants ʻo A, E, a me C he mau antioxidants pū kekahi. No laila ʻo ia nā mea hana ikaika a mākou e hana ai me ka hoʻohaʻahaʻa ʻana i ke kaumaha o ke kino. Hoʻokuʻu mākou i ka nui o nā toxins. A i ka hele ʻana o ke kī ʻōmaʻomaʻo i loko o ka squirt, e kinai iā lākou, hoʻomaʻalili iā lākou, a hoʻokuʻu iā lākou i waho. E noʻonoʻo i hea kahi ʻāpana ʻē aʻe e kōkua ai i ka hana ʻana o ka insulin holoʻokoʻa, ʻo ia ka puʻupaʻa. Holoi ʻia nā puʻupaʻa me ke kī ʻōmaʻomaʻo a laila kōkua pū kekahi. ʻIke au i hoʻokahi mea āu i hana ʻole ai, e Astrid, ua hana ʻia nā ʻatikala ma ka turmeric, ʻeā?

 

ʻO Astrid Ornelas: ʻAe, ua hana au i nā ʻatikala he nui e pili ana i ka turmeric. ʻIke wau no ka mea, mai ka papa inoa ma luna, ʻo ka turmeric a me ka curcumin e like paha me kekahi o kaʻu mea punahele punahele e kamaʻilio ai.

 

Kauka Alex Jimenez DC*: ʻAe, ua like ʻo ia me ka nahu ʻana i ke aʻa a ʻelua mau manawa.

 

ʻO Astrid Ornelas: ʻAe, aia kekahi i loko o kaʻu pahu hau i kēia manawa.

 

Kauka Alex Jimenez DC*: ʻAe, hoʻopā ʻoe i kēlā turmeric, a nalowale ka manamana lima. Ua aha ko'u manamana lima? Ua hoʻokokoke ʻoe i kaʻu turmeric? ʻO ke kumu, pololei? No laila. No laila e haʻi iki iā mākou e pili ana i nā waiwai o ka turmeric a me ka curcumin e pili ana i ka metabolic syndrome.

 

ʻO Astrid Ornelas: OK. Ua hana au i kekahi mau ʻatikala e pili ana i ka turmeric a me ka curcumin. A ua kamaʻilio pū mākou ma mua, a ʻo kekahi o kā mākou podcasts a me ka turmeric i hala, ʻo ia ka mea hiki ke nānā ʻia ka melemele melemele i kekahi poʻe, akā ua kapa ʻia ʻo ia he kumu melemele. A kaulana loa ia i ka meaʻai India. ʻO ia kekahi o nā meaʻai nui āu e ʻike ai i ka curry. A ʻo curcumin, maopopo maoli ua lohe kekahi o ʻoukou i ka curcumin a i ʻole turmeric, ʻike ʻoe? He aha ka ʻokoʻa? ʻAe, ʻo ka turmeric ka mea kanu pua, a ʻo ke kumu. ʻAi mākou i ke aʻa o ka turmeric, a ʻo curcumin wale nō ka mea hana i loko o ka turmeric e hāʻawi ai i ke kala melemele.

 

Kauka Alex Jimenez DC*: E nā kāne, ʻaʻole wau e ʻae i nā mea maʻi ʻē aʻe akā ʻo ke ʻano kiʻekiʻe o ka curcumin a me nā huahana turmeric i loaʻa i kā lākou poʻe maʻi no ka mea he ʻokoʻa. Hoʻohana ʻia kekahi mau mea me ka maoli, ʻo wau hoʻi, loaʻa iā mākou nā solvents, a me ke ʻano o ka lawe ʻana i nā mea a me ka curcumin a me ka turmeric a i ʻole nā ​​​​mea like me ka cocaine, pono ʻoe e hoʻohana i kahi distillate. OK? A inā paha he wai, acetone, benzene, OK, a i ʻole kekahi ʻano huahana, ʻike mākou i kēia lā ua hoʻohana ʻia ka benzene e hana i nā ʻano mea hoʻohui, a hoʻohana kekahi mau hui i ka benzene e loaʻa ai ka maikaʻi mai ka turmeric. ʻO ka pilikia ʻo benzene ka mea e hana ai i ka maʻi kanesa. No laila pono mākou e makaʻala loa i nā ʻoihana a mākou e hoʻohana ai. Acetone, e noʻonoʻo i kēlā. No laila aia nā kaʻina hana no ka unuhi pono ʻana i ka turmeric a maikaʻi. No laila, i ka loaʻa ʻana o ka turmeric kūpono, ʻaʻole like nā turmeric a pau. A ʻo ia kekahi o nā mea a mākou e loiloi ai no ka mea he nui nā huahana o ka honua e holo pupule maoli ana e hoʻāʻo e hoʻoponopono i ka turmeric a pololei, ʻoiai ʻo ia ka mea hope a mākou e kūkākūkā nei i kēia lā ma kā mākou kumuhana. Akā ʻo ia kekahi o nā mea nui i kēia lā. ʻAʻole maopopo iā mākou ka aspirin. ʻIke mākou he hana ia, akā ʻaʻole e haʻi ʻia ka nui o ia mea. Eia naʻe, aia ka turmeric i ka moku hoʻokahi. Ke aʻo nui nei mākou e pili ana i ia mea i kēlā me kēia lā, i kēlā me kēia mahina, e hana ʻia ana nā haʻawina e pili ana i ka waiwai o ka turmeric i loko o ka meaʻai kūlohelohe, no laila ua paʻa ʻo Astris i ka pahuhopu i kēlā. No laila, maopopo iaʻu e lawe mai ana ʻo ia i ia mea iā mākou, ʻeā?

 

ʻO Astrid Ornelas: Ae 'oia. 

 

Kauka Alex Jimenez DC*: No laila ke manaʻo nei au he mea hiki iā mākou ke hana i kēia lā ke nānā mākou i kēia, makemake wau e nīnau iā Kenna, ke nānā mākou i kahi metabolic syndrome mai nā hōʻike ʻana o nā hōʻailona a i ʻole mai nā haʻawina ʻoihana. ʻO ka hilinaʻi o ka ʻike ʻana ua like ʻo N i hoʻokahi o nā mea pono i loaʻa iā mākou i kēia manawa i ka lāʻau lapaʻau hana a me nā hana olakino e hana nei ka nui o nā kauka lapaʻau kino i kā lākou ʻano hana. No ka mea ma nā pilikia metabolic, ʻaʻole hiki iā ʻoe ke lawe i ka metabolic mai ke kino. Loaʻa ka metabolism i kahi pilikia hope? ʻIke mākou i ka pilina me nā ʻeha hope, ʻeha hope, nā pilikia hope, nā maʻi kuli mau, nā maʻi musculoskeletal hui pū ʻana, a me ka metabolic syndrome. No laila ʻaʻole hiki iā mākou ke hoʻohenehene. No laila, e haʻi iki mai iā mākou, e Kenna, i ko mākou hoʻopau ʻana i kēia lā i kahi mea e hiki ai i ka mea maʻi ke manaʻo i ka wā e hele mai ai lākou i kā mākou keʻena, a hoʻokomo ʻia lākou i ka "Oops, loaʻa iā ʻoe ka metabolic syndrome." No laila boom, pehea mākou e hana ai?

 

Kenna Vaughn: Makemake mākou e ʻike i ko lākou ʻano no ka mea, e like me kāu i ʻōlelo ai, pili nā mea a pau; hohonu nā mea a pau. Aia nā kikoʻī makemake mākou e ʻike i nā mea āpau i hiki iā mākou ke hana i kēlā hoʻolālā pilikino. No laila kekahi o nā mea mua a mākou e hana ai he nīnau nīnau lōʻihi loa na Living Matrix, a he mea hana maikaʻi loa ia. He manawa liʻiliʻi ia, akā hāʻawi ia iā mākou i ka ʻike nui i ka mea maʻi, he mea maikaʻi loa ia no ka mea hiki iā mākou, e like me kaʻu i ʻōlelo ai, e ʻeli hohonu a noʻonoʻo, ʻike ʻoe, nā traumas i hiki ke alakaʻi i ka mumū. , ʻo ia ka mea a Astrid i ʻōlelo ai e alakaʻi i kēlā ʻano noho sedentary, a laila alakaʻi i kēia metabolic syndrome a i ʻole ke ʻano o ke ala. No laila, ʻo kekahi o nā mea mua a mākou e hana ai, ʻo ia ka hana ʻana i kēlā nīnau nīnau lōʻihi, a laila noho mākou a kamaʻilio pū me ʻoe. Kūkulu mākou i hui a hoʻolilo iā ʻoe i ʻāpana o ko mākou ʻohana no ka mea ʻaʻole maʻalahi kēia mau mea e hele me ka hoʻokahi, no laila ʻo ka lanakila nui loa ke loaʻa iā ʻoe kēlā ʻohana pili, a loaʻa iā ʻoe kēlā kākoʻo, a ke hoʻāʻo nei mākou e lilo i kēlā oe.

 

Kauka Alex Jimenez DC*: Ua lawe mākou i kēia ʻike a ʻike mākou he paʻakikī loa ia i ʻelima mau makahiki i hala. He mea paʻakikī. 300 300-ʻaoʻao nīnau nīnau. I kēia lā, loaʻa iā mākou nā polokalamu i hiki iā mākou ke noʻonoʻo. Kākoʻo ʻia ia e ka IFM, ka Institute of Functional Medicine. Ua hoʻomaka ka Institute of Functional Medicine i nā makahiki he ʻumi i hala a kaulana loa, me ka hoʻomaopopo ʻana i ke kanaka holoʻokoʻa ma ke ʻano he kanaka. ʻAʻole hiki iā ʻoe ke hoʻokaʻawale i ka pōpō maka mai ke ʻano o ke kino no ka mea ʻaʻole hiki iā ʻoe ke hoʻokaʻawale i ka metabolism mai nā hopena āpau i loaʻa iā ia. Once kēlā kino a me kēlā meaʻai, kēlā nutraceutical kēlā meaʻai e komo i ko mākou kino. Aia ma kekahi ʻaoʻao o ko mākou waha kēia mau mea kaumaha liʻiliʻi i kapa ʻia he chromosomes. Ke wili nei lākou, a ke wili nei lākou, a ke hana nei lākou i nā enzymes a me nā protein e pili ana i kā mākou hānai iā lākou. No ka ʻike ʻana i ka mea e hana nei, pono mākou e hana i kahi nīnau nīnau e pili ana i ka ʻuhane kino kino. Hāʻawi ia i ka mīkini o ka hoʻoheheʻe maʻamau, pehea ka hana ʻana o ka entanglement, a pehea ka hopena o ka ʻike ola holoʻokoʻa i loko o ke kanaka. No laila ke noʻonoʻo pū nei mākou iā Astrid lāua ʻo Kenna, ʻano ʻike mākou i ke ala maikaʻi loa, a loaʻa iā mākou kahi kaʻina hana i hana ʻia no kēlā me kēia kanaka. Kapa mākou iā ia ʻo ka IFM hoʻokahi, ʻelua, a me ʻekolu, he mau nīnau paʻakikī e hiki ai iā mākou ke hāʻawi iā ʻoe i kahi loiloi kikoʻī a me ka haʻihaʻi pololei o kahi e hiki ai ke kumu a me nā nutraceuticals nā meaʻai meaʻai a mākou e nānā ai. Paipai mākou iā ʻoe i ke ala pololei i kahi e pono ai i loko o ka lumi kuke. Hoʻopau mākou i ke aʻo ʻana iā ʻoe a me kou ʻohana pehea e hānai ai i hiki iā ʻoe ke lilo i mea maikaʻi i kēlā mau genetic genomes, ʻo ʻoe, e like me kaʻu e ʻōlelo mau nei, ontogeny, recapitulates phylogeny. ʻO mākou nō mākou mai ka wā kahiko a hiki i ka poʻe, a ʻo kēlā poʻe he pae ma waena o mākou a me koʻu hala, a ʻo nā mea a pau i hala. A ʻo ia kā mākou genetics, a pane kā mākou genetics i ke kaiapuni. No laila inā e hele wikiwiki ana i ka hema a i ʻike ʻia a i ʻike ʻia paha, e kūkākūkā mākou i kēlā mau mea, a e komo koke mākou i ka honua o genomics i kēia kaʻina i ko mākou hele hohonu ʻana i ke kaʻina metabolic syndrome. No laila, ke hoʻomaikaʻi aku nei au iā ʻoukou a pau no ka hoʻolohe ʻana mai iā mākou a ʻike hiki iā mākou ke hoʻopili ʻia ma ʻaneʻi, a e haʻalele lākou iā ʻoe i ka helu. Akā iā mākou ʻo Astrid ma ʻaneʻi e hana nei i ka noiʻi. Loaʻa iā mākou kahi hui i hoʻokumu ʻia e nā poʻe he nui e hiki ke hāʻawi iā ʻoe i ka ʻike maikaʻi loa e pili ana iā ʻoe; N like hoʻokahi. Loaʻa iā mākou ʻo Kenna ma ʻaneʻi e loaʻa mau ana a aia mākou e mālama nei i nā poʻe ma kā mākou kūlanakauhale liʻiliʻi nani ʻo El Paso. No laila, mahalo hou, a e kakali i ka podcast e hiki mai ana, aia paha i loko o nā hola ʻelua e hiki mai ana. E leʻaleʻa ai. ʻAe, e nā kāne. 

ʻO nā hoʻololi pale i hoʻohuiʻia me ka maʻi paʻi

ʻO nā hoʻololi pale i hoʻohuiʻia me ka maʻi paʻi

ʻO kaʻeha keʻano o ke kino o ke kino o ke kanaka i ka hōʻeha a maʻi paha, a he mea hoʻomanaʻo pinepine paha he mea hewa. I ka manawa e ola ai ka pilikia, hiki iā mākou ke ho'ōki i ka loaʻaʻana o kēia mau hōʻailona pōʻino, akā, pehea ka hopena i ka manawa e mau ai kaʻeha ma hope o ka halaʻana o ke kumuhana? maʻi eha ua ho'ākāka 'ia me ka lāʻau e like me ke kaumaha mau e mau ana i ka 3 i ka mau makahiki 6 aʻoi aʻe paha. ʻO ka pilikia nui loa kahi pilikia e ola ai me ka hoʻopiliʻana i nā mea a pau mai ka papahana hana a ka mea a me ka mea hiki ke hana a me kā lākou mau pilina pilikino a me nā kūlana koʻikoʻi. Akā, uaʻike aneiʻoe e pili ana paha ka hopena maʻamau i ka hanana a me ka hana o kou lolo? Hiki ke hoʻololi i kēia mau loli o ka lolo e hiki ai i ka hoʻohaʻahaʻa a me ka naʻauʻole.

 

ʻO ke kaumaha nuiʻaʻole ia e hoʻololi wale i kahi māhele'āina o ka manaʻo, he meaʻoiaʻiʻo, hiki ke hopena i nā loli i nā wahi nui o ka lolo, aʻo ka hapa nui o ia mau mea e komo i nā hana a me nā hana. Uaʻike nāʻano noiʻi noiʻi i nā makahiki he mau hanana i ka hippocampus, me ka hoʻemiʻana i nā meaʻeleʻele mai ka cortex prefrontal dorsolateral, amygdala, pūpū a me ka pono pūpū pono, e kapa i kekahi, e pili ana me kaʻeha mau. Hiki i ka hoʻohaunaeleʻana o kekahi mau hanana o kēia mau āpana a me kā lākou mau hana pili e kōkua i ka hoʻololiʻana o kēia lolo i loko o ka pōʻaiapili, no ka nui o nā poʻe me kaʻeha mau loa. ʻO ke kumu o ka pauku ma hope iho nei, e hōʻike a kūkākūkā paha i nā loli o ka lolo a me ka hana hana e pili ana i kaʻeha mau loa, ma keʻano ināʻaʻole e hōʻinoʻia nā mea a me nā meaʻole.

 

ʻO nā hoʻololiʻana o nā Brain i ke Kūlana Palekana E Hōʻoia IʻoleʻAʻohe Pōʻino A iʻole Atrophy paha

 

Hōʻuluʻulu Manaʻo

 

Pili ka ʻeha ʻeha me ka lolo i ka hoʻoliʻiliʻi mea i nā wahi e like me ka lawe ʻana o ka ʻeha. ʻO nā kaʻina hana morphological e pili ana i kēia mau hoʻololi hoʻololi, e pili ana paha i ka hoʻoponopono hou ʻana i ka hana a me ka plasticity kikowaena i ka lolo, noho maopopo ʻole. ʻO kaʻeha ma ka hip osteoarthritis kekahi o nā syndrome ʻeha mau loa e hiki ke mālama ʻia. Nānā mākou i nā maʻi he 20 me ka ʻeha mau ma muli o ka coxarthrosis unilateral (mean makahiki 63.25-9.46 (SD) mau makahiki, 10 wahine) ma mua o ke kīpiʻi endoprosthetic hui (state pain) a nānā i nā loli o ka lolo a hiki i 1 makahiki ma hope o ke kahakaha ʻana: 6-8 mau pule , 12--18 mau hebedoma a me 10--14 mahina ke kaʻawale loa ka ʻeha. ʻO nā mea maʻi me ka ʻeha mau ma muli o ka coxarthrosis unilateral i ka liʻiliʻi o ka hina hina i ka hoʻohālikelike ʻia i nā kaohi o ka cingulate cort (c), cortex insular a me ka operculum, dorsolateral prefrontal cortex (DLPFC) a me orbitofrontal Cortex. Hana kēia mau wahi ma ke ʻano he mau hoʻohui hoʻohui lehulehu i ka wā o ka ʻike a me ka kali o ka ʻeha. I ka wā i ʻeha ai nā mea maʻi ma hope o ka hoʻōla ʻia ʻana mai ke ʻoki endoprosthetic, ua hoʻonui ʻia kahi mea hina i aneane like nā wahi like. Ua ʻike pū kekahi mākou i kahi piʻi holomua o ka mea hina poʻo lolo i ka premotor cortex a me kahi o ka moto hoʻonui (SMA). Hoʻoholo mākou ʻaʻole nā ​​mea hina i ka ʻeha mau ke kumu, akā ke lua i ka maʻi a ma ka liʻiliʻi i hapa ma muli o nā loli i ka hana kaʻa a me ka hoʻohui kino.

 

Introduction

 

ʻO nā hōʻike o ka hana hou a me ke kūkulu hou ʻana i nā mea maʻi ʻeha mau e kākoʻo i ka manaʻo ʻaʻole pono e noʻonoʻo ʻia ka ʻeha mau loa ma ke ʻano he kūlana hana i hoʻololi ʻia, akā ma muli o ka hopena o ka plasticity o ka lolo hana a me ka hanana [1], [2], [3], [4], [5], [6]. I nā makahiki ʻeono i hala iho nei, ua paʻi ʻia ma mua o 20 mau haʻawina e hōʻike ana i ka loli ʻana o ka lolo hanana i 14 syndromes ʻeha mau. ʻO kahi hiʻohiʻona hiʻohiʻona o kēia mau noiʻi āpau ka ʻoiaʻiʻo ʻaʻole i hoʻokaʻawale wale ʻia nā mea hina, akā i kū ʻia i nā wahi lolo i ho'ākāka ʻia a me ka hana maʻamau - ʻo ia hoʻi, ke komo ʻana i ka hana nosiceptive supraspinal. ʻO nā mea i ʻike nui ʻia he ʻokoʻa ia no kēlā me kēia maʻi ʻehaʻeha, akā ua kau ʻia i ka cingulate cortex, ka orbitofrontal cortex, ka insula a me nā dorsal pons [4]. ʻO nā hale hou aʻe ka hui o ka thalamus, dorsolateral prefrontal Cortex, basal ganglia a me ka wahi hippocampal. Kūkākūkā pinepine ʻia kēia mau hopena e like me ke atrophy pūnaewele, e hoʻoikaika ana i ka manaʻo o ka hōʻino a i ʻole ka nalo ʻana o ka hina hina o ka lolo [7], [8], [9]. ʻO ka ʻoiaʻiʻo, ua ʻike nā mea noiʻi i ka hoʻopili ma waena o ka lolo hina mea hoʻemi a me ka lōʻihi o ka ʻeha [6], [10]. Akā pili ka lōʻihi o ka ʻeha i ka makahiki o ka mea maʻi, a me ka makahiki i hilinaʻi ʻia ma ka honua holoʻokoʻa, akā ua hōʻike maikaʻi ʻia ka hāʻule kikoʻī ʻana o ka hina hina [11]. Ma ka ʻaoʻao ʻē aʻe, hiki i kēia mau hoʻololi kūloli ke hoʻemi i ka nui o ka cell, nā wai extracellular, synaptogenesis, angiogenesis a i ʻole ma muli o nā loli o ka nui o ke koko [4], [12], [13]. ʻO kēlā me kēia kumu, no kā mākou wehewehe ʻana i ia ʻano hopena he mea nui e ʻike i kēia mau ʻike morphometric i ka mālamalama o ka waiwai o nā noiʻi morphometric i ka plasticity dependant e pili ana, no ka mea ua hōʻike pinepine ʻia nā loli lolo i nā wahi kikoʻī ma hope o ka noʻonoʻo a me ka hoʻoikaika kino. 14].

 

ʻAʻole maopopo ʻia ke kumu o ka hapa liʻiliʻi o nā kānaka e hoʻomohala i kahi maʻi ʻeha mau loa, e noʻonoʻo nei he ʻeha ākea ka ʻeha. Kū aʻe ka nīnau inā paha i kekahi mau kānaka kahi ʻokoʻa o ka hanana i ka lawe ʻana i nā ʻōnaehana ʻeha waena e hana ma ke ʻano he diathesis no ka ʻeha mau. Hoʻololi nā mea hina i ka ʻeha phantom ma muli o ka ʻoki ʻana [15] a me ka ʻeha o ke kuamoʻo [3] e hōʻike ana i nā hoʻololi morphological o ka lolo, ma ka liʻiliʻi i kahi ʻāpana, kahi hopena o ka ʻeha mau. Eia nō naʻe, ʻo kaʻeha o ka hip osteoarthritis (OA) kekahi o nā maʻi o ka maʻi mau loa e hiki ke hiki ke mālama ʻia, ʻoiai ʻo 88% o kēia mau mea maʻi he kūʻokoʻa i ka ʻeha ma hope o ke kīʻaha hope. (16). I loko o kahi noiʻi pailaka ua nānā mākou i nā maʻi he ʻumi me ka huina OA ma mua a ma hope koke iho o ke kaha ʻana. Ua ʻike mākou i nā hōʻemi o nā mea hina i ka mua cingulated Cortex (ACC) a me ka insula i ka wā o ka ʻeha mau ma mua o ke kahakaha THR a loaʻa ka hoʻonui ʻia o nā mea hina i nā wahi lolo e pili ana i ka ʻeha manuahi ma hope o ke kahakaha ʻana [17]. Ke nānā nei i kēia hopena, ua hoʻonui mākou i kā mākou noiʻi e noiʻi ana i nā mea maʻi hou aʻe (n? =? 20) ma hope o THR kūleʻa a nānā i nā loli o ka lolo i nā manawa ʻehā, a hoʻokahi makahiki ma hope o ke kaukō ʻana. E kāohi i nā mea hina hina ma muli o ka hoʻomaikaʻi ʻana o ka moto a i ʻole ke kaumaha i lawelawe pū mākou i nā palapala nīnau no ka hoʻomaikaʻi ʻana i ka hana kaʻa a me ke olakino noʻonoʻo.

 

Nā Pono a me nā Una

 

'O Volunteers

 

Ua hōʻike ʻia nā mea maʻi ma aneʻi he lālā o 20 mau maʻi mai 32 mau maʻi i paʻi ʻia i hala iho nei i hoʻohālikelike ʻia i kahi hui mālama olakino kūlike i ka makahiki a me ke kāne a me ke komo ʻana i kahi noiʻi hou aʻe o hoʻokahi makahiki. Ma hope o ke kahakaha ʻana he 17 mau mea maʻi i hāʻule ma muli o ke kaha ʻelua endoprosthetic (n? =? 12), nā maʻi nui (n? =? 2) a me ka haʻalele ʻana o ka ʻae (n? =? 2). Ua haʻalele kēia i kahi hui he iwakālua mau maʻi me ka unilateral kumu mua o ka huina OA (mean makahiki 8--63.25 (SD) makahiki, 9.46 wahine) i ʻimi ʻia ʻehā mau manawa: ma mua o ke kaha ʻana (state pain) a hou 10-6 a me 8-12 mau hebedoma a me 18 10 mau mahina ma hope o ke kaha ʻana o ka endoprosthetic, ke ʻole ka ʻehaʻeha. ʻO nā mea maʻi āpau me ka hip hip mua loa he moʻolelo mōʻaukū ka lōʻihi ma mua o 14 mau mahina, mai ka 12 a i ka 1 mau makahiki (mean 33 mau makahiki) a me ka helu ʻeha ʻeha o 7.35 (mai 65.5 a 40) ma kahi pālākiō analogue visual (VAS) mai 90 (ʻaʻohe ʻeha) i 0 (ʻeha ʻeha maikaʻi ʻole. Ua loiloi mākou i kekahi hanana o nā hanana ʻeha liʻiliʻi, e like me ka niho-, pepeiao a me ka ʻehaʻeha a hiki i nā hebedoma 100 ma mua o ke aʻo ʻana. Ua koho koho ʻole mākou i ka ʻikepili mai ka 4 sex- a me nā makahiki i kū like i nā kaohi olakino (mean makahiki 20--60,95 (SD) mau makahiki, 8,52 wahine) o ka 10 o ka noiʻi pailota i ʻōlelo ʻia ma luna [32]. ʻAʻohe o nā maʻi he 17 a i ʻole ka 20 wahine a me nā makahiki i kūlike i nā mea manawaleʻa olakino i loaʻa i ka mōʻaukala a me ka mōʻaukala kūloko. Ua hāʻawi ʻia ke aʻo ʻana e ka komite Ethics kūloko a ʻae ʻia i ʻike ʻia i kākau ʻia i loaʻa mai i nā mea hoʻopaʻa haʻawina ma mua o ka hoʻokolokolo ʻana.

 

Kaʻikepili Behavioral

 

Ua hōʻiliʻili mākou i nā ʻikepili e pili ana i ke kaumaha, somatization, hopohopo, ʻeha a me ke olakino a me ke olakino noʻonoʻo i nā mea maʻi āpau a me nā helu ʻehā a pau e hoʻohana ana i nā nīnau nīnau maʻamau: Beck Depression Inventory (BDI) [18], Brief Symptom Inventory (BSI) [19], Schmerzempfindungs-Skala (SES? =? Pālua ʻoluʻolu ʻole o ka ʻeha) [20] a me ka Health Survey 36-Item Short Form (SF-36) [21] a me ka Nottingham Health Profile (NHP). Ua alakaʻi mākou i nā ana ANOVA a pālua i nā hoʻāʻo t-tiled ʻelua e kālailai i ka ʻikepili luhi lōʻihi e hoʻohana ana iā SPSS 13.0 no Windows (SPSS Inc., Chicago, IL), a hoʻohana i ka hoʻoponopono Greenhouse Geisser inā ua haki ka kuhi no ka sphericity. Ua hoʻonohonoho ʻia ka pae koʻikoʻi ma p <0.05.

 

VBM -ʻIkeʻIkepili

 

Loaʻa kiʻi kiʻi. Ua hana ʻia ka nānā ʻana MR kiʻekiʻe-kiʻekiʻe ma kahi ʻōnaehana 3T MRI (Siemens Trio) me kahi wili poʻo poʻo 12-kanal maʻamau. No kēlā me kēia helu o nā manawa ʻehā, scan I (ma waena o 1 lā a me 3 mahina ma mua o ke kahakaha endoprosthetic), scan II (6 a 8 mau pule ma hope o ke kahakaha ʻana), scan III (12 a 18 mau pule ma hope o ke kahakaha ʻana) a scan IV (10-14 mau mahina ma hope o ke kahakaha ʻana), loaʻa kahi T1 kaumaha MRI kūkulu no kēlā me kēia mea maʻi me ka hoʻohana ʻana i ke kaʻina 3D-FLASH (TR 15 ms, TE 4.9 ms, ʻaoʻao flip 25 ", ʻāpana 1 mm, FOV 256-256, nui voxel 1--1-- 1 mm).

 

Ka HoʻolālāʻImi a me kaʻIke Heluhelu

 

Hana ʻia ka ʻike mua a me ka hoʻopili ʻana me SPM2 (Wellcome Department of Cognitive Neurology, Ladana, UK) e holo ana ma lalo o Matlab (Mathworks, Sherborn, MA, USA) a me ka mea i loko o kahi morphometry (VBM) -toolbox no ka ʻikepili lonikū, kēlā hoʻokumu ʻia i nā kiʻi 3D MR hoʻolālā hoʻonā kiʻekiʻe loa a ʻae i ka noi ʻana i nā helu helu voxel-wisdom e ʻike i nā ʻokoʻa āpana i ka hina hina o nā mea a i ʻole nā ​​puke [22], [23]. I ka hōʻuluʻulu manaʻo, ʻo ka hana mua ʻana e pili ana i ka normalization spatial, ka mahele hinahina a me ka hoʻoheheʻe spatial 10 mm me kahi hua hua Gaussian. No nā kaʻina hana mua, ua hoʻohana mākou i kahi protocol i hoʻomākaukau ʻia [22], [23] a me kahi scanner- a me kahi anakuhi mea kikoʻī kikoʻī manaʻo [17]. Ua hoʻohana mākou iā SPM2 ma mua o SPM5 a i ʻole SPM8 e hoʻohālikelike i kēia kālailai i kā mākou pailota aʻo [17]. e like me ka mea e ʻae ai i kahi normalization maikaʻi loa a me ka hoʻokaʻawale ʻana o ka ʻikepili lōʻihi. Eia nō naʻe, ma ke ʻano he hōʻano hou o VBM (VBM8) i loaʻa i kēia manawa (dbm.neuro.uni-jena.de/vbm/), ua hoʻohana mākou iā VBM8.

 

Kaʻike 'ana i ke kaulike

 

Ua hoʻohana mākou i kahi hoʻāʻo t-hoʻāʻo lua i mea e ʻike ai i nā ʻokoʻa āpau i ka hina hina o ka mea ma waena o nā hui (nā mea maʻi ma ka manawa kiko scan I (ʻeha mau) a me nā kaohi olakino). Ua noi mākou i kahi paepae o ka p <0.001 (uncorrected) ma o ka lolo holoʻokoʻa ma muli o ko mākou ikaika i kahi kuhiakau nui, i hoʻokumu ʻia ma 9 mau noiʻi kūʻokoʻa a me nā cohorts e hōʻike ana i ka emi ʻana o ka mea hina i nā mea maʻi maʻi mau. 7], [8], [9], [15], [24], [25], [26], e hoʻonui ʻia ka mea hina i nā wahi like (no ka hana ʻeha e pili ana) nā wahi e like me kā mākou papa pailaka (27 ). Ua hoʻohālikelike ʻia nā hui no ka makahiki a me ka moekolohe me ka ʻole o nā ʻokoʻa koʻikoʻi ma waena o nā hui. No ka ʻimi inā ua loli nā ʻokoʻa ma waena o nā hui ma hope o hoʻokahi makahiki, ua hoʻohālikelike mākou i nā mea maʻi i ka manawa kiko scan IV (ʻeha manuahi, hoʻokahi makahiki ka ukali) i kā mākou papa mālama olakino.

 

Ka Hoʻoponopono Longitudinal

 

E ʻike i nā ʻokoʻa ma waena o nā helu manawa (Scan IIV) ua hoʻohālikelike mākou i ka scanner ma mua o ke kaha ʻana (state pain) a me 6-8 a me 12-18 mau pule a me 10-14 mau mahina ma hope o ke kaha ʻana o ka endoprosthetic (pain pain) e like me ke ana hou ANOVA. Ma muli o ka loli ʻana o ka lolo ma muli o ka ʻeha mau e pono ai i kahi manawa e hoʻi ai ma hope o ka hana a me ka hoʻomaha ʻana o ka ʻeha a ma muli o ka ʻeha hope o ka ʻokiʻoki i hōʻike ʻia e nā mea maʻi, ua hoʻohālikelike mākou i ka loiloi loiloi lōʻihi I a me II me ka scan III a me IV. No ka ʻike ʻana i nā loli ʻaʻole pili pono i ka ʻeha, ua nānā pū mākou no nā loli holomua i nā manawa āpau. Ua hoʻohuli mākou i ka lolo o nā mea maʻi me OA o ka ʻaoʻao hema (n? =? 7) i mea e maʻamau ai no ka ʻaoʻao o ka ʻeha no nā mea ʻelua, ka hoʻohālikelike ʻana o ka hui a me ka loiloi lōʻihi, akā ua nānā mua i ka ʻikepili i hoʻohuli ʻole ʻia. Ua hoʻohana mākou i ka helu BDI ma ke ʻano he covariate i ke kkohu.

 

Results

 

Kaʻikepili Behavioral

 

Ua hōʻike ʻia nā mea maʻi āpau i ka ʻeha mau loa ma mua o ka ʻoki a ʻaʻohe ʻeha (e pili ana i kēia ʻeha mau) ma hope koke o ke kaha ʻana, akā ua hōʻike ʻia kahi ʻeha ma hope o ke kaha ʻana ma ka scan II i ʻokoʻa a ʻeha hoʻi ma muli o ka osteoarthritis. Ka helu olakino noʻonoʻo SF-36 (F (1.925 / 17.322)? =? 0.352, p? =? 0.7) a me ka helu BSI ma ka honua holoʻokoʻa GSI (F (1.706 / 27.302)? =? 3.189, p? =? 0.064 ) ʻaʻole i hōʻike i nā loli i ka holo ʻana o ka manawa a ʻaʻohe pili pū kekahi o ka noʻonoʻo. ʻAʻole hōʻike ʻia kekahi o nā kaohi i kahi ʻehaʻeha a ʻeha mau paha a ʻaʻole i hōʻike ʻia kekahi ʻōuli o ke kaumaha a me ke kīnā ʻole o ke kino / noʻonoʻo.

 

Ma mua o ke kaha ʻana, hōʻike kekahi mau mea maʻi i nā ʻōuli depressive haʻahaʻa ma nā helu BDI i hoʻemi nui ʻia ma ka scan III (t (17)? =? 2.317, p? =? 0.033) a me IV (t (16)? =? 2.132, p? =? 0.049). Hoʻohui ʻia, hoʻomaikaʻi maikaʻi nā helu SES (ʻoluʻolu ʻole) o nā mea maʻi āpau mai ka scan I (ma mua o ke ʻoki ʻana) e scan II (t (16)? =? 4.676, p <0.001), scan III (t (14)? =? 4.760, p <0.001) a me ka scan IV (t (14)? =? 4.981, p <0.001, 1 makahiki ma hope o ke kaha ʻana) e like me ka hōʻemi ʻana o ka ʻeha me ka ʻeha o ka ʻeha. He maikaʻi ka helu helu ʻeha ma ka scan 1 a me 2, ka helu like i ka lā 3 a me 4 maikaʻi ʻole. Hōʻike wale ka SES i ka maikaʻi o ka ʻeha i ʻike ʻia. No laila maikaʻi ia ma ka lā 1 a me 2 (mean 19.6 ma ka lā 1 a me 13.5 ma ka lā 2) a me ka maikaʻi ʻole (na) ma ka lā 3 & 4. Eia naʻe, ʻaʻole maopopo kekahi o nā mea maʻi i kēia kaʻina hana a hoʻohana i ka SES ma ke ʻano he kaulike ana i ke ola. ʻO kēia ke kumu i nīnau ʻia ai nā mea maʻi āpau i ka lā like pākahi a me ka mea like e pili ana i ka hanana ʻeha.

 

I ka papa olakino kino olakino olakino (SF-36), i piha me nā ana hōʻuluʻulu manaʻo o kahi Helu olakino kino a me kahi helu olakino noʻonoʻo [29], ua hoʻomaikaʻi maikaʻi nā mea maʻi i ka helu olakino olakino mai ka scan I i scan II (t ( 17)? = ?? 4.266, p? =? 0.001), scan III (t (16)? = ?? 8.584, p <0.001) a me IV (t (12)? = ?? 7.148, p <0.001), akā ʻaʻole ma ka Helu Ola Mental. Ua like nā hopena o ka NHP, i ka subscale ppain (hoʻoliʻiliʻi polarity) ua ʻike mākou i kahi hoʻololi nui mai ka scan I i scan II (t (14)? = ?? 5.674, p <0.001, scan III (t (12 )? = ?? 7.040, p <0.001 a me ka scan IV (t (10)? = ?? 3.258, p? =? 0.009). Ua ʻike pū kekahi mākou i kahi piʻi nui o ka subscale mobility phimum mai ka scan I i scan III (t (12)? = ?? 3.974, p? =? 0.002) a me ka scan IV (t (10)? = ?? 2.511, p? =? 0.031). ʻAʻohe hoʻololi nui ma waena o ka scan I a me ka scan II ( ʻeono pule ma hope o ke kaha ʻana.

 

Kaʻikepili helu

 

Loaʻa mahele o ke kaʻina. Ua hoʻokomo mākou i ka makahiki ma ke ʻano he covariate i ka laulā laina laulā a ʻike ʻole i ka huikau o ka makahiki. Hoʻohālikelike ʻia i ka moekolohe a me nā makahiki i hoʻohālikelike ʻia, ua hōʻike nā mea maʻi me ka hip mua OA (n? =? 20) i ka pre-operative (Scan I) e hoʻoliʻiliʻi i ka mea hina i ka cexulate cingulate cortex (ACC), ka huina insular, operculum, dorsolateral prefrontal Cortex ( DLPFC), ka pou kino ʻākau a me ka cerebellum (Papa 1 a me ke Kii 1). Koe no ka putamen kūpono (x? =? 31, y? = ?? 14, z? = ?? 1; p <0.001, t? =? 3.32) ʻaʻole i loaʻa ka hoʻonui nui ʻana i ka nui o nā mea hina i nā mea maʻi me ka OA i hoʻohālikelike ʻia. i nā kaohi olakino. Ke hoʻohālikelike nei i nā mea maʻi i ka manawa kiko scan IV me nā kaohi i kūlike ʻia, ua loaʻa nā hopena like e like me ka mahele ʻāpana o ka ʻāpana e hoʻohana ana i ka scan I hoʻohālikelike ʻia i nā kaohi.

 

Hōʻike Nānā 1 Makahiki Pāʻali Kūlana

Kiʻi 1: Nā palapala 'āina parametric e hōʻike ana i nā ʻokoʻa o ke ʻano o ka hina hina i nā maʻi me ka ʻeha mau ma muli o ka hip OA mua i hoʻohālikelike ʻia i nā mana a me ka lōʻihi i hoʻohālikelike ʻia iā lākou iho i ka manawa. Hōʻike ʻia nā hoʻololi nui hina hina i ke kala, hōʻike ʻia ka ʻikepili cross-sectional i ka ʻikepili ʻulaʻula a me ka longitudinal i ka melemele. Axial plane: ʻo ka ʻaoʻao hema o ke kiʻi ka ʻaoʻao hema o ka lolo. kiʻekiʻe: Nā wahi o ka emi nui o ka mea hina ma waena o nā maʻi me ka ʻeha mau ma muli o ka hip OA mua a me nā kumuhana mana ʻole. p<0.001 i hoʻoponopono ʻole ʻia: piʻi ka mea hina i nā maʻi ʻeha ʻole 20 i ke kolu a me ka ʻehā o ka manawa ma hope o ka hoʻololi ʻana i ka hip, ke hoʻohālikelike ʻia me ka scan mua (preoperative) a me ka lua (6-8 mau pule ma hope o ke kaʻina hana). P<0.001 Nā ʻāpana ʻaʻole i hoʻoponopono ʻia: ʻO nā manaʻo hoʻohālikelike a me 90% ka wā hilinaʻi, nā hopena o ka hoihoi, nā ʻāpana kūʻokoʻa. axis-x: nā ʻokoʻa no nā manawa 4, axis-y: kuhi ʻokoʻa ma ?3, 50, 2 no ACC a me ka helu ʻokoʻa ma 36, ​​39, 3 no ka insula.

 

Ka PapahanaʻIkepili Cross 1

 

Ke hoʻololi nei i ka ʻikepili o nā maʻi me ka ʻūhā hema OA (n? =? 7) a me ka hoʻohālikelike ʻana iā lākou me nā kaohi olakino ʻaʻole i hoʻololi i nā hopena, akā no ka hōʻemi ʻana o ka thalamus (x? =? 10, y? = ?? 20, z? =? 3, p <0.001, t? =? 3.44) a me ka hoʻonui ʻia o ka cerebellum akau (x? =? 25, y? = ?? 37, z? = ?? 50, p <0.001, t? =? 5.12) ʻaʻole i hiki i ka mea nui i ka ʻike pili ʻole o ka poʻe maʻi ke hoʻohālikelike ʻia i nā kaohi.

 

Ka lōʻihi lōʻihi. I ka loiloi lōʻihi, ua ʻike ʻia kahi hoʻonui nui (p <.001 uncorrected) o ka mea hina e ka hoʻohālikelike ʻana i ka scan mua a me ka lua (ʻeha mau / ʻeha hope) a me ka scan ʻekolu a ʻehā (manuahi ʻole) ma ka ACC, insular cortex, cerebellum a me pars orbitalis i nā mea maʻi me ka OA (Papa 2 a me ke Kii 1). Ua emi ka hina hina ma luna o ka manawa (p <.001 kuhi ʻokoʻa i ka lolo) i ka lua o ka somatosensory cortex, hippocampus, midcingulate cortex, thalamus a me caudate nucleus i nā mea maʻi me OA (Kiʻi 2).

 

Hōʻaia ka helu 2 ma ka Brain Gray Matter

Hōʻike 2: a) Hoʻonui ka nui o ka hina hina o ka lolo ma hope o ka holomua o ka hana. ʻIke axial o ka hoʻoliʻiliʻi koʻikoʻi o ka hina hina i nā mea maʻi me ka ʻeha mau ma muli o ka hip hip mua e hoʻohālikelike ʻia i nā kumuhana kaohi. p <0.001 i hoʻoponopono ʻole ʻia (ʻāpana ʻāpana ʻāpana), b) Hoʻonui ka lōʻihi o ka hina hina i ka manawa ma ka melemele e hoʻohālikelike ana i ka scan I & IIscan III> scan IV) i nā mea maʻi me OA. p <0.001 uncorrected (longitudinal analysis). ʻO ka ʻaoʻao hema o ke kiʻi ka ʻaoʻao hema o ka lolo.

 

Ka Papahana Pūnaewele Longnudinal 2

 

Ke hoʻololi nei i ka ʻikepili o nā mea maʻi me ka ʻūhā hema OA (n? =? 7) ʻaʻole i hoʻololi i nā hopena, akā no ka hoʻoliʻiliʻi o ka hina hina o ka lolo i ka Heschl Gyrus (x? = ?? 41, y? = ?? 21, z? =? 10, p <0.001, t? =? 3.69) a me Precuneus (x? =? 15, y? = ?? 36, z? =? 3, p <0.001, t? =? 4.60) .

 

Ma ka hoʻohālikelike ʻana i ka scanning mua (presurgery) me ka scans 3 + 4 (posturgery), ua ʻike mākou i ka hoʻonui ʻia o ka mea hina i ka mua o ka Cortex a me ka moto (p <0.001 uncorrected). Hoʻomaopopo mākou he ʻoi aku ka paʻakikī o kēia ʻokoʻa ke loaʻa iā mākou i kēia manawa ka liʻiliʻi o nā scans no kēlā me kēia ʻano (ʻeha vs. non-pain). Ke hoʻohaʻahaʻa mākou i ka paepae hana hou mākou i nā mea i loaʻa iā mākou e hoʻohana ana i ka hoʻohālikelike o 1 + 2 vs. 3 + 4.

 

Ma ka ʻimi ʻana i nā wahi e hoʻonui i nā wā āpau, ua ʻike mākou i nā loli o ka hina hina o ka lolo i nā wahi kaʻa (ʻĀpana 6) i nā mea maʻi me ka coxarthrosis ma hope o ka huina hope o ka hika (scan Idbm.neuro.uni-jena.de/vbm/) hiki iā mākou ke hoʻohālikelike i kēia ʻike i ka mua a me ka mid-cingulate cortex a me nā insulae mua.

 

Ua helu mākou i nā nui o ka hopena a me ka hōʻuluʻulu ʻāpana (nā maʻi a me nā kaohi) i loaʻa kahi Cohenss o 1.78751 i ka voxel piko o ka ACC (x? = ?? 12, y? =? 25, z? = ?? 16). Ua helu mākou iā Cohensss no ke aniani longitudinal (hoʻohālikelike scan scan 1 + 2 vs. scan 3 + 4). Ua hopena kēia i kahi Cohenss o 1.1158 i ka ACC (x? = ?? 3, y? =? 50, z? =? 2). E pili ana i ka insula (x? = ?? 33, y? =? 21, z? =? 13) a pili i ka like like, ʻo Cohen s 1.0949. Hoʻohui ʻia, ua helu mākou i ke kumu o nā helu voxel non-zero o ka palapala ʻāina Cohen ma loko o ka ROI (i loko o ka mahele mua o ka cingulate gyrus a me ka subcallosal cortex, i lawe ʻia mai ka Harvard-Oxford Cortical Structural Atlas): 1.251223.

 

Dr-Jimenez_White-Coat_01.png

Dr. Alex Jimenez's Insight

Hiki i nā'ōpiopio maʻi ke loaʻa i nā hanana olakino āpau o ka manawa, keʻole i nā hōʻailona keu o ke kino. Eia kekahi lā, he nui nā kānaka eʻike i nā pilikia e hiamoe ana ma muli o ka hopena, akā,ʻo ka mea nui loa,ʻo kaʻeha lōʻihi e hiki ai ke alakaʻi i nā hihia no ke olakino, e like me ka manaʻo kaumaha a me ke kaumaha. ʻO nā hopena i hiki i kaʻeha ke loaʻa i ka lolo, hiki paha ke nānā aku i nā mea koʻikoʻi nui akāʻo nā hōʻike ulu e hōʻike anaʻaʻole hiki ke loli kēia lolo a hiki ke hoʻohuliʻia i ka wā e loaʻa ai ka lāʻau kūpono i nā maʻi o nā maʻi. Wahi a kaʻatikala,ʻo nā meaʻinoʻeleʻele i loaʻa i loko o kaʻeha mau loa e hōʻikeʻole i ka pōʻino o ka lolo, akā, he hopena pinepine ia e kūpono ke mālama ponoʻia kaʻeha. ʻO ka mea pōmaikaʻi, hiki ke kōkua i kahi mau hōʻailona kūpono e kōkua ai i ka hōʻemi i nā hōʻailona hōʻailona a hoʻoulu hou i ka hale a me ka hana o ka lolo.

 

kūkākūkā

 

Ke nānā nei i ka hana o ka lolo holoʻokoʻa i ka manawa, hōʻoia mākou a hoʻonui i kā mākou ʻike pilote i paʻi ʻia i hala iho nei [17]. Ua loaʻa iā mākou nā loli i ka mea hina o ka lolo i nā mea maʻi me ka osteoarthritis hip mua i ka mokuʻeha mau loa, kahi e hoʻi i ka hapa ke loaʻa ʻole ka ʻeha o kēia mau mea maʻi, ma hope o ke kīʻaha endoprosthetic hui pū ʻia. ʻO ka hoʻonui hapa ʻana o ka mea hina ma hope o ke kaha ʻana he ʻaneʻane ma nā wahi like i ʻike ʻia ai ka emi ʻana o ka hina hina ma mua o ke kaha ʻana. ʻO ka hoʻopili ʻana i ka ʻikepili o nā mea maʻi me ka ʻūhā hema o OA (a no laila maʻamau no ka ʻaoʻao o ka ʻeha) he mea nui wale ka hopena ma nā hopena akā ua hōʻike pū kekahi i ka hoʻoliʻiliʻi o ka hina hina i ka gyrus a Heschl a me Precuneus i hiki ʻole iā mākou ke wehewehe maʻalahi a, ʻoiai ʻaʻohe kuhiakau o ka priori, e nānā me ke akahele. Eia nō naʻe, ʻo ka ʻokoʻa i ʻike ʻia ma waena o nā mea maʻi a me nā kaohi olakino ma ka scan ʻana ua ʻike mau ʻia wau i ka hoʻopili ʻāpana ʻāpana i ka scan IV. ʻO ka hoʻonui ʻana o ka mea hina i ka manawa o ka manawa he maʻalahi, ʻo ia hoʻi ʻaʻole i lawa ka hoʻokaʻawale ʻana i kahi hopena ma ka ʻāpana ʻāpana o ke keʻa, kahi ʻike i hōʻike ʻia i nā noiʻi e noiʻi ana i ka ʻike pili i ka plasticity [30], [31]. Hoʻomaopopo mākou i ka ʻoiaʻiʻo e hōʻike mākou i kekahi mau ʻāpana o ka lolo-loli ma muli o ka ʻeha mau e hoʻi hou ʻia ʻaʻole ia e kāpae i kekahi mau ʻāpana o kēia mau loli i hiki ʻole ke hoʻihoʻi ʻia.

 

ʻO ka mea mahalo, uaʻike mākou i ka emiʻana o ka hina hina ma ka ACC i nā maʻi maʻi mau loa ma mua o ka hanaʻana i ka holoʻana i ka 6 mau wiki ma hope o ke kāpili (scan II) a hoʻonui waleʻia i ka'ōʻiliʻili III a me IV, hiki paha i ka paʻi hopeʻana o ke kahakaha, hana. Loaʻa kēia i kaʻike o nā'ōnaehana no ka hoʻolālā paʻakikī i komo i loko o ka NHP, kahi i hōʻikeʻole i ka hoʻololi nui i ka manawa II ma kahi o ka pāʻaniʻana akā ua nui ka piʻiʻana i ka'ōnaehana III a me IV. ʻO kaʻike, ua hōʻikeʻoleʻia ko mākou mau maʻi i kaʻeha i loko o ka'alē ma hope o ke kāpiliʻana, akā, loaʻa kaʻeha i hope o ka paeʻana i nāʻiʻo a me kaʻili iʻikeʻia e ka poʻe maʻi. Eia nō naʻe, i ka manawa i hōʻike pinepine ai nā mea maʻi i ke kaumaha ma ka scan II, hoʻohālike pū mākou i ka'ōkuhi mua (ka hana mua) me ka scans III + IV (ke kauʻana), e hōʻike ana i ka hoʻonuiʻana i ka meaʻeleʻele i mua o ka palekana mua a me ka hoʻokele pua. Hoʻomaopopo mākou he paʻakikī kēia kūkēkēʻana ma muli o ke emi o ka mīkini maʻamau (ʻo ka maʻi a me ka maʻiʻole). Ke hoʻohaʻahaʻa iho nei mākou i ka paepae, haʻi hou mākou i nā mea i loaʻa iā mākou ma ka hoʻohālikeʻana o I + II vs III + IV.

 

Hōʻike ikaika kā mākou ʻikepili i ka hoʻololi ʻana o nā mea hina i nā maʻi o ka maʻi mau, i ʻike pinepine ʻia ma nā wahi e pili ana i ka hana supraspinal nociceptive [4] ʻaʻole no ka atronal neuronal a me ka hōʻino ʻana o ka lolo. ʻO ka ʻike o kēia mau hoʻololi i ʻike ʻia i ka mokuʻāina ʻeha mau ʻole i hiki ke wehewehe ʻia me kahi wā pōkole o ka nānā ʻana (hoʻokahi makahiki ma hope o ka hana me ke ʻano o ʻehiku mau makahiki o ka ʻeha mau ma mua o ka hana. Ua loli ka lolo Neuroplastic i ulu paha i mau makahiki (no ka hopena o ka hoʻokomo mau ʻana o ka nociceptive) pono i kahi manawa hou aku e huli hope loa. ʻO kahi hiki ke ʻike ʻia ka hoʻonui ʻana o ka hina hina i ka ʻikepili longitudinal akā ʻaʻole ma ka ʻikepili o ka ʻaoʻao (ʻo ia ma waena o nā cohorts i ka manawa o ka manawa IV) ka liʻiliʻi o ka nui o nā mea maʻi (n? =? 20). Pono e kuhikuhi ʻia ka ʻokoʻa ma waena o ka lolo o kekahi mau kānaka he nui a loaʻa i ka ʻikepili longitudinal ka liʻiliʻi o ka ʻokoʻa e like me ka nānā ʻana o nā lolo like i nā manawa he nui. A laila, e ʻike wale ʻia nā loli lahilahi ma ka ʻikepili lonikū [30], [31], [32]. ʻAʻole hiki iā mākou ke kāpae i kēia mau loli ma ka liʻiliʻi i hiki ʻole ke hoʻihoʻi ʻia ʻoiai ʻaʻole paha ia, hāʻawi ʻia nā hopena o ka hoʻolālā pilikino kikoʻī a me ka hoʻoponopono hou ʻana [4], [12], [30], [33], [34]. I mea e pane ai i kēia nīnau, pono nā noiʻi e hiki mai ana e nānā pinepine i nā mea maʻi ma mua o nā manawa lōʻihi, he mau makahiki paha.

 

Hoʻomaopopo mākou e hiki iā mākou ke hana i nā hopena i kau waleʻia e pili ana i ka ikaika o ka lolo morphology i ka manawa. ʻO ke kumu ke kūkulu mākou i kēia noi ma 2007 a nānāʻia i ka 2008 a me ka 2009,ʻaʻole iʻikeʻia inā e loli ana nā hoʻololi kūlohelohe a no nā kumu o ka pono i koho ai mākou i nā lāpili a me nā papa manawa e like me ia i ho'ākākaʻia maʻaneʻi. Hiki i kekahi ke hoʻopaʻapaʻa i ka loli o ka hina i ka manawa, a mākou e wehewehe ai no ka pūʻulu maʻi, hiki paha i ka hui pūʻulu a me ka hopena. Eia naʻe,ʻo nā hoʻololiʻana no kaʻelemakule, inā he nui, e manaʻoʻia he emi iho ka nui. Hāʻawiʻia ko mākou kuhiakau mua, ma muli o nā noiʻi kūʻokoʻa 9 a me nā kākoʻo e hōʻike ana i ke emiʻana o ka mea hina i nā mea maʻi maʻamau [7], [8], [9], [15], [24], [25], [26] [27], [28], ke kālele nei mākou i nā hoʻonui ākea ma kahi o ka manawa a no laila manaʻoʻiʻoʻaʻole mākou he hopena manawa maʻalahi. No kaʻike,ʻaʻole hiki iā mākou ke hoʻoholo i ka emiʻana o ka hina hina i ka manawa i loaʻa iā mākou i loko o ko mākou maʻi hoʻomanawanui i hiki i ka hopena manawa, no ka mea,ʻaʻole mākou i nānā i kā mākou papa hana i ka manawa hoʻokahi. Hāʻawiʻia nā hopena, he pono e hoʻonuiʻia ka hoʻolālāʻana i nā manawa a me nā wā pōkole, no ka mea, hiki i ka hana ma hope o ka wikiwiki morphometric ka wikiwiki e like me ka 1 wiki [32], [33].

 

Ma waho aʻe o ka hopena o ka maʻi o ka maʻi ma luna o ka mea hina [17] [34], [6] uaʻike mākou i nā loli i kaʻoihana hana hiki ke kōkua pū paha i nā hoʻololi. Loaʻa iā mākou kahi kaʻa a me nā wahi kikowaena (3 āpau) e hoʻonui i nā wā āpau (Figure 35). Ma muli o ka noʻonoʻo pono paha kēia ma muli o ka hoʻomaikaʻiʻana i kaʻoihana kaʻaʻoi aku i ka manawa aʻo ka mea i hoʻomahaʻoleʻia ai ka poʻe ola i ka nohoʻana i ke ola maʻamau. ʻO keʻano,ʻaʻole mākou i nānā aku i ka hana kaʻa akā i ka hoʻonuiʻana i kaʻike o ka maʻi, hāʻawiʻia i kā mākou noi mua eʻimi ai i ka loli maikaʻi o ka loloʻeleʻele i nā maʻi maʻi mau. No laila,ʻaʻole mākou i hoʻohana i nā mea kiko'ī eʻimi ai i ka hana maʻamau. Eia nō naʻe, ua hoʻoponopono ponoʻia ka hui houʻana o nā huihuʻi me ka maʻi paʻi [36], [37], [38], [39]. Eia kekahi,ʻo ka huakiko kaʻa he mea nui ia ma nāʻano maʻi lapaʻau i nā mea maʻi maʻamau i loaʻa i ka lāʻau me ka hoʻohanaʻana i ka hoʻonākau o ka lolo maʻamau (40), [41], me ka hoʻonāʻano o ka manawa kūʻokoʻa [42], a me ka hoʻonāʻano keʻakeʻa hou [43], [40]. ʻO ka hoʻohālikelike o kēiaʻano hoʻololi (kōkua me ka hanaʻole, a me ka pale waleʻana i nā pūnaewele pili i nā maʻi)ʻaʻole i hoʻonuiʻia i [13]. Ua hōʻikeʻia kahi hōʻike hou nei e hiki i kekahiʻikeʻike maʻamau ke hoʻololi i ka pilina o ka lolo [44]. ʻO ka synaptogenesis, ka hoʻohui houʻana o ka hōʻike a me ka angiogenesis i ka hana pūkō kino e hiki ke hana me nā koi kūikawā o kahi hana kaʻa. Tsao et al. Hōʻike i ka hoʻouka houʻana i loko o ka huakiko kaʻa o nā maʻi me kaʻeha hope haʻahaʻa e hoʻihoʻiʻia ana e like me ka mea i hōʻano houʻia [45] a me Puri et al. uaʻikeʻia ka emiʻana o ka mea'āpana'āpana'āpana'āpana poʻo hina i ka meaʻoluʻolu o ka fibromyalgia (28). ʻAʻole i hanaʻia kā mākou aʻoʻana no ka weheweheʻana i nāʻano likeʻole e hiki ai ke hoʻololi i ka lolo i loko o kaʻeha mau loa akā ua wehe mākou i kā mākouʻikepili e pili ana i ka hina hina e hoʻololi wale i nā hopena o ka hoʻokomoʻoleʻana i nā manaʻo. ʻO kaʻoiaʻiʻo,ʻo kahi noiʻi hou i nā maʻi maʻi neuropathic ka mea i hōʻike ai i nā mea likeʻole ma nāʻaoʻao o ka lolo e pili ana i ka manaʻo noʻonoʻo, ka pilikino, a me kaʻike o ke kaumaha, e'ōlelo ana he mea koʻikoʻi lākou i ka hoʻolālā kiʻi honua o XNUMX.

 

Hōʻike Nānā 3 Makahiki Pāʻali Kūlana

Hōʻike 3: Nā palapala ʻāina parametric helu e hōʻike ana i ka hoʻonui nui ʻana o ka mea hina hina ma nā wahi kaʻa (ʻĀpana 6) i nā mea maʻi me ka coxarthrosis ma mua o ka hoʻohālikelike ʻia ma hope o THR (ka loiloi lōʻihi, scan I Kuhi hoʻohālikelike ma x? =? 19, y? = ?? 12, z? =? 70.

 

ʻElua mau papahana kūlana hope loa e pili ana i ka hoʻoponopono pani paniʻana i nā maʻi o ka maʻi osteoarthritis,ʻo ia wale nō ka maʻi o ka maʻi mau loa e hiki ke kōkua i nā mea likeʻole [17], [46] pani manawa a me kēia mauʻikepili i hoʻopiʻiʻia e kahi noi hou loa i nā maʻi maʻi haʻahaʻa haʻahaʻa. 47]. Pono eʻikeʻia kēia mau haʻawina ma ka mālamalama o kekahi mau loiloi lōʻihi e nānā ana i nā mea iʻikeʻoleʻia ma ka hanana e like me ka [30], [31] a me kahi noi hou o nā lolo i nā mea kōkua olakino e hoʻonāukiuki ana i ka hoʻonāukiukiʻana [34] . ʻO ka hua'ōlelo nui o kēia mau haʻawina aʻo ka hoʻokaʻawale nui i ka hanu o ka lolo ma waena o nā maʻi a me nā mana ke kāohi i ka wā e ho'ōlaʻia ai ka maʻi. Eia naʻe, pono e noʻonoʻoʻiaʻaʻole maopopo i ka loliʻana o nā mea maʻi maʻamau no ka hoʻokomoʻole iʻole ka hopena o ka maʻi a me nā meaʻelua. ʻOiaiʻoi aku ka nui o nā loli maʻamau, e like me ka hopena a hoʻonui paha i ka pilina o ka pilina, ke kuʻi, ka hoʻonaʻauao kino a me nā hoʻololi o ke ola e lawa i ka lolo [6], [12], [28], [48]. ʻO ke kaumaha nui loaʻo ia ka mea lapaʻau a me ka hopena o kaʻeha, he mea noi nui ke ho'ākāka i kaʻokoʻa ma waena o nā maʻi a me nā mana. ʻO kekahi poʻe liʻiliʻi o kā mākou mau maʻi meʻOA ua hōʻike i nā hōʻailona hoʻohaʻahaʻa i hoʻololiʻia i ka manawa. ʻAʻole mākou iʻike i ka hoʻololiʻana i nā papa hana me ka papa BDI-akā ua loaʻa ka nīnau i ka nui o nā loli halihali no ka nele o kaʻeha a me ka hoʻoikaika kaʻaʻana i nā hopena a me keʻano o ka hana. Hiki i kēia mau loli hana ke hoʻoikaika i ka emi o ka hina hina i ka maʻi mau loa a me ka ulu hina ma ka pauʻana o kaʻeha.

 

ʻO kekahi kumu nui'ē aʻe paha e hōʻeha i kā mākou weheweheʻana i nā hualoaʻa,ʻo ia hoʻi,ʻo nā mea maʻi a pau loa me kaʻeha mau loa i loaʻa nā lāʻau e pili ana i kaʻeha, a ua kū lākou i ka wā iʻole ai lākou e hoʻoluhiʻia. Hiki i kekahi ke hoʻopaʻapaʻa e pili ana nā NSAID e like me diclofenac a iʻole ibuprofen i kekahi mau hopena ma nā pūnaewele neural a he pono ia no nā opioids, nā antiepileptics a me nā antidepressants, nā lāʻau i hoʻohana pinepineʻia i loko o ka pain pain cure. ʻO ka hopena o kaʻeha killers a me nā lāʻau'ē aʻe e pili ana i nā'ikepona morphometric e nui paha (48). ʻAʻohe aʻo i kēia manawa i hōʻikeʻia nā hopena o nā lāʻau paʻi ma ka lolo o ka lolo akā uaʻikeʻia kekahi mau pepa i ka hoʻololiʻana i ka hanu o ka maʻi i nā mea maʻi maʻamauʻole i wehewehe waleʻia e ka maʻi hana piliʻole [15],ʻaʻole hoʻi ma [7] maʻi [9] [49]. Eia naʻe, ua nele nāʻike kūpono. Pono e hoʻonui hou ka noiʻi i nā loli o kaʻike i ka pilikino i loko o ka plasticity, hiki ke nui nā hopena o ka hopena no ka mālamaʻana i kaʻeha mau loa.

 

Uaʻike mākou i ka emiʻana o ka mea hina i ka nānāʻana o longitudinal, hiki paha i nā papahana hou e hoʻohuiʻia me ka hoʻololiʻana i ka hana a me kaʻike i ka maʻi. ʻAʻoleʻike iki nāʻike e pili ana i nā loli lōʻihi i ka lolo hina ma nāʻanoʻeha, no laila ke kumuʻole o kā mākou kuhiakau no ka emiʻana o ka hina hina ma kēia mau wahi ma hope o ka hana. Teutsch et al. Uaʻikeʻia [25] ka piʻiʻana o ka meaʻeleʻele i ka lolo a me ke kāpili i waena o nā limahana olakino iʻike i ka hoʻonāukiuki i ka hana maʻamau i nā lāʻewalu. ʻO ka loaʻa o ka'āpana kala hina e piʻi ma hope o ka hoʻomohala hoʻomohalaʻana i ka hoʻokomo o ka lolo i ka mea maʻamau i ka heluʻana i nā maʻi i ho'ōlaʻia no kaʻeha mau loa. Hōʻike kēia i ka hoʻokomo maikaʻiʻole i nā limahana olakino e alakaʻi i ka hoʻoikaika i nā hoʻololi o ka hoʻokele, e like me ka mea i loaʻa i nā maʻi me kaʻeha mau loa, a ke hoʻololi nei kēia mau loli i nā limahana olakino i ka pauʻole o nā komo komo. No laila, hiki ke hoʻohālikelikeʻia ka emiʻana o ke oho hina ma kēia mau wahi iʻikeʻia i nā maʻi me kaʻOA ma muli o ke kaʻina hana likeʻole: hoʻoikaika i ka hoʻololi i nā loli o ka lolo [50]. Ma keʻano he kaohiʻole,ʻo MR Morphometry ka meaʻoi loa no kaʻimiʻana eʻike i nā substrate morphological o nā maʻi, e hoʻonui ana i ka maopopo o ka pilina ma waena o ka lolo a me ka hana, a me ka nānāʻana i ka hanaʻana. ʻO kekahi o nā pahuhopu nui i ka wā e hiki mai ana,ʻo ia ka hoʻololiʻana i kēia mea hana ikaika no nā hoʻokolohua nui a me nā ho'āʻo maikaʻi o kaʻeha mau.

 

Ka palena o kēia aʻoʻana

 

ʻOiai ke hoʻonui ʻia kēia noi o kā mākou noi mua e hoʻonui nei i ka ʻikepili ukali i 12 mau mahina a me ka ʻimi ʻana i nā mea maʻi hou aʻe, ʻo kā mākou kumu ʻike i ka loli o ka lolo morphometric i ka ʻeha mau. Liʻiliʻi ka nui o nā hopena (ʻike ma luna) a hoʻohele hapa ʻia nā hopena e ka hōʻemi hou ʻana o ka nui o ka hina o ka lolo i ka manawa o ka scan 2. Ke hoʻokaʻawale mākou i ka ʻikepili mai ka scan 2 (pololei ma hope o ka hana) nui wale hoʻonui i ka mea hina hina o ka lolo no ka pahū kaʻa a me ke alo o mua e ola i kahi paepae o p <0.001 i hoʻoponopono ʻole ʻia (Papa 3).

 

Ka Papahana Pūnaewele Longnudinal 3

 

Panina

 

ʻAʻole hiki keʻike i keʻano o ka hoʻololiʻana i kūkuluʻia a mākou iʻikeʻia ai ma muli o ka loliʻana i ka hoʻokomoʻoleʻana, ka hoʻololiʻana i ka hana kaʻa a iʻole ka lāʻau lāʻau a iʻole nā ​​loli o ka noho maikaʻiʻana. Ma ka paleʻana i nā kuhi likeʻole o ka'ōkuhi mua a me ka hope loa me kekahi me ka hōʻike i ka emi o kaʻokoʻa ma mua o ka mea i manaʻoʻia. Ma muli paha o ka hoʻololiʻana o ka lolo ma muli o ka hopena maʻamau a me nā hopena e ulu nei ma kahi lōʻihi loa a hiki i ka manawa e hoʻi hou ai. Akā, eia nā hopena e hōʻike i nā hanana o ka hoʻoponopono houʻana, e hōʻike ana i ka hoʻokomoʻana o ka hanaʻole a me ka hōʻehaʻana i ka maʻi ma kēia mau maʻi e alakaʻi i ka hana maʻalili i nā wahi kai o ka'āina.

 

mau hoomaikai ana

 

Mahalo nui mākou i nā mea limahana a pau no ke komoʻana i kēia noi a me kaʻaoʻao Physics and Methods i NeuroImage Nord ma Hamburg. Ua hāʻawiʻia ke aʻoʻana i ka'āpono kūpono e ka Kōmike Ethics a me kaʻae i kākauʻia ma ka hoʻomaopopoʻana mai nā mea noiʻi a pau ma mua o ka hoʻokolokoloʻana.

 

Kālāʻike kālā

 

Ua kākoʻoʻia kēia hana ma nā haʻawina mai ka DFG (German Research Foundation) (MA 1862 / 2-3) a me BMBF (The Federal Ministry of Education and Research) (371 57 01 a me NeuroImage Nord). ʻAʻole nā ​​kuleana o ka waihona kālā ma ka hoʻolālā aʻo, ka hōʻiliʻili a me ke kānana hōʻiliʻili, ka hoʻoholo e hoʻolaha, a iʻole hoʻomākaukauʻana paha i ka puke.

 

ʻO Endocannabinoid Pūnaewele | El Paso, TX Chiropractor

 

ʻO ka ʻōnaehana Endocannabinoid: ʻO ka ʻōnaehana nui āu i lohe ʻole ai

 

Ināʻaʻoleʻoe i lohe e pili ana i ka pūnaewele endocannabinoid, aiʻole ECS paha,ʻaʻole ponoʻoe e hilahila. Ma hope o ka 1960, hiki i nā meaʻimi noiʻi i lilo i mea makemake i ka hana ola o Cannabis ka mea nui loa o kāna mau hana hana. Ua laweʻia kekahi mau 30 makahiki hou, no ka mea, nā mea noiʻi e aʻo i nā'ōmeʻa holoholona e huli i kahi hōʻailona no kēia mau mea ECS i loko o ka noʻonoʻo o nā koho, kahi mea e wehe ai i ka honua holoʻokoʻa no ka nīnauʻana i nā EC receptors existence a me kā lākou kumuhana physiological.

 

I kēia manawa,ʻike mākou i ka nui o nā holoholona, ​​mai ka iʻa a me nā manu, nā endocannabinoid, aʻike mākouʻaʻole i hana wale nā ​​kānaka i kā lākou mau cannabino e pili pū ana me kēia pūnaewele, akā, hana pū mākou i nā pūnaewele e pili ana me ka ECS, iʻikeʻia i nāʻano mea kanu a me nā meaʻai likeʻole, ma mua o nāʻano o ka lāʻauʻo Cannabis.

 

Ma keʻano he kiko o ke kino o ke kanaka,ʻaʻole kahi papahana kūʻokoʻa o ka ECS e like me keʻano o ka'ōpiopio pūnaewele a iʻole ka pūʻulu maʻi. Ma ka hakahaka, ua hoʻonohonoho likeʻia ka ECS i nā huipuni i hoʻokaʻawaleʻia i loko o ke kino e hoʻoukaʻia ana ma o kahi pūhui liʻiliʻi a mākou iʻike ai he endocannabinoids, aiʻole cannabinoids hope. Hōʻikeʻia nā mea hōʻoia hōʻoiaʻo CB1 a me CB2, akā he mau mea'ē aʻe i manaʻoʻia. Hiki i nā lālā PPAR a me TRP ke pale i kekahi mau hana. Penei, e loaʻa iāʻoeʻelua mau endocannabinoids maikaʻi: anadamide a me 2-arachidonoyl glycerol, aiʻole 2-AG.

 

Eia kekahi,ʻo ke kumu o ka endocannabinoid pūnaha,ʻo ia nā enzymes e hōʻanoho a hōʻoki i nā endocannabinoids. Hoʻopiliʻia nā endocannabinoids i ka synthesized i kahi kahua e pono ai. ʻO nā kumuhana enzymes i loko,ʻo ia ka diacylglycerol lipase a me ka N-acyl-phosphatidylethanolamine-phospholipase D, aʻo ia ka synthesize 2-AG a me anandamide. ʻO nā enzymes hōʻano nuiʻelua he fatty acid amide hydrolase, aiʻole FAAH, ka mea e hakihaʻi i ka anandamide, a me monoacylglycerol lipase, a MAGL paha, e haki ai i ka 2-AG. Hoʻopiʻi a hōʻemi paha ka hoʻoponoponoʻana i kēia mau enzymesʻelua i ka modulation o ka ECS.

 

He aha ka hana o ka ECS?

 

ʻO ka ECS ke kumuhana homeostatic mana o ke kino. Hiki hiki ke nānāʻia e like me ke kino o ka pūnaeho adaptogenic i loko, e hana mau e mālama i ke kaulike o nāʻano hana. Hoʻopiʻi ka Endocannabinoid i ka hanaʻo neuromodulators a, no iaʻano, hoʻoponopono lākou i nāʻano o ke kino, mai ka uluʻana i kaʻeha. ʻO kekahi o ia mau hana iʻoi aku ka maikaʻi ma ka ECS penei:

 

ko mākou hopohopo System

 

Mai ke kikowaena pūnaewele, a iʻole ka CNS, hiki i ka hoʻokiʻekiʻe nui o nā mea hāpai CB1 ka mea e pāpā i ka hoʻokuʻuʻana i ka glutamate a me GABA. I loko o ka CNS, ua hoʻokumu ka ECS i ka hana a me ka aʻoʻana i ka hoʻomanaʻo, hoʻonui i ka neurogenesis ma ka hippocampus, e hoʻoponopono ai i ka mea nui e hiki ai. Hiki i ka ECS kekahi hapa ma ke ala e hana ai ka lolo i kaʻeha a me ka mumū. Mai ke poʻo o ka'ōpū, ua hoʻoponopono ka ECS i ka hōʻeha a hōʻeha i nā kānalua kūlohelohe. I loko o ka pūnaewele puni honua, i ka mālamaʻana o CB2 mana, ke hana nui nei ka ECS ma kahi pūnaewele puni honua e hoʻoponopono ai i nā hana o ka'ōpū, urinary, a me nā papa hānau.

 

Paha a me ka Mood

 

He nui nā hopena o ka ECS ma luna o nā haunaele kaumaha a me nā loina o ka manaʻo, e like me ka hoʻomakaʻana o kēia pane i ke koʻikoʻi koʻikoʻi a me ka hoʻololiʻana i ka manawa no nā manaʻo lōʻihi lōʻihi, e like me ka makaʻu a me ka hopohopo. He mea koʻikoʻi kahi hana endocannabinoid hana maikaʻi e pili ana i keʻano o ka hoʻololiʻana o nā kānaka ma waena o kahi māʻona maikaʻi o ka huhū i ka hoʻohālikelikeʻana i kahi paeʻoiʻoi aʻoiʻole keʻoluʻolu. Hiki i ka ECS ke hana i ka hoʻomanaʻo i ka hoʻomanaʻo a hiki paha i keʻano o ka lolo e hoʻokomo i ka hoʻomanaʻo mai ka pilikia a iʻole kaʻeha. Ma muli o ka ECS hoʻololi i ka hoʻokuʻuʻana o dopamine, noradrenaline, serotonin, a me cortisol, hiki iā ia ke hoʻohuli ākea i ka pane a me nā hana.

 

Pūnaehana Huahaʻi

 

Ua hoʻopiliʻia ka'ōpala me nā CB1 a me CB2 e hoʻoponopono ana i kekahi mauʻano nui o ka olakino GI. Ke manaʻo nei pahaʻo ka ECS paha ka "pūnaewele e nalowale nei" ma ka ho'ākākaʻana i ka pilina o ka pūpū e pili ana i ka'ōpū-me ka liʻiliʻi e komo nui ana i kaʻoihana olakino o ka'ōpala pahū. ʻO ke ECS he mea hoʻokele o ka hopena o ke kīpē, ma muli paha o ka hoʻopiliʻana i ka pūnaehana hoʻopiliʻole mai ka lukuʻana i ka lauoho maikaʻi, a ma o ka hoʻololiʻana i ka hōʻailona cytokine. Hoʻoponopono ka ECS i ka pane o ka'elepuni kūlohelohe i loko o ka'ōhumu'ōpala, a he nui nā hopena no ka nui o nā hihia olakino. ʻO Gastric a me GI pūnaewele nui ka mea e hoʻomalu ponoʻia e ka ECS.

 

ʻAi a me ka Metabolism

 

ʻO ka ECS,ʻo ia hoʻi nā'āpana CB1, ke pāʻani i ka makemake, ka hanaʻana, a me ka hoʻoponoponoʻana i ke kino. ʻO ka hoʻoweliweliʻana o nā mea loaʻa ka CB1 e hoʻonui i kaʻimi i ka meaʻai, hoʻonui i kaʻike i kaʻala, hoʻoponopono hoʻi i ka palekana ike. ʻO nā holoholona a me nā kānaka i paʻakikū, ua loaʻa iā lākou ka loiloi ECS e hiki ke alakaʻi i kēia pūnaewele i mea hana maikaʻi, kahi e hoʻoikaika ai i ka hoʻouluʻana a me ka hoʻemiʻana i ka hoʻokele. Hoʻonuiʻia ka hoʻolālāʻana i nā anana o ka anandamide a me ka 2-AG i ka nui, kahi i lilo ma ka hapa no ka emiʻana o ka hanaʻana o ka enzyme hōʻinoʻana o FAAH.

 

ʻO ka pane'eleponaʻole a me ka huhū

 

ʻO nā pūnaewele a me nā'ōpuni o ka pūnaewele immune ua lako i nā mea loaʻa me nā endologicobinoid. Hoʻomaopopoʻia nā hopena o Cannabinoid i loko o ka momona o koumus, nā kaula, nā pūpū, a me ka momona o ka iwi, a me nā T-a me nā B-lymphocytes, macrophages, nā mast cells, neutrophils, a me nā pūpoki kaulua maoli. Uaʻikeʻia ka ECS ma keʻano he mea hoʻokele kaʻawale o ka palekana a me ka homeostasis. ʻOiaiʻaʻole maopopo nā hana a pau o ka ECS mai ka'ōnaehana kamepiula, ua hoʻonohonoho ka ECS i ka hoʻoponoponoʻana i ka cytokine a me ka hana i ka paleʻana i ka hanaʻino i loko o ka pūnaewele immune. ʻO ka hoʻonaeho he māhele maoli ia o ka pane o ka immune, a he hana kūpono loa ia i nā'ōlelo hōʻino i ke kino, e like me nāʻeha a me nā maʻi; Akā naʻe, ināʻaʻole mālamaʻia, hiki iā ia ke lilo i mea hoʻomanaʻo a kōkua i ka hopena o nā pilikia o ka pilikia, e like me ke kaumaha mau. Ma ka mālamaʻana i ka pane āpau o ke kaʻina, e kōkua ka ECS i ka mālamaʻana i ka pane'elepona iʻoi aku ka palekana ma o ke kino.

 

Nāʻokoʻa aʻe o ke olakino i hoʻoponoponoʻia e ka ECS:

 

  • Nani ka maʻi
  • Māmā
  • ʻO ke ola pale
  • ʻO ka ola olakino a me ka hanuʻana
  • ʻO ka moe a me ka circadian rhythm

 

Pehea e kākoʻo maikaʻi ai i kahi ECS olakino kahi nīnau nui a nā mea noiʻi e ho'āʻo nei e pane. E hoʻomanaʻo no kaʻike hou aku i kēia kumuhana i hoʻomaka.

 

I ka hopena,Ua pili ka ʻeha syncronic me nā loli o ka lolo, me ka hoʻoliʻiliʻi o ka hina mea. Eia naʻe, ua hōʻike ʻia ka ʻatikala ma luna aʻe e hiki i ka ʻeha mau ke hoʻololi i ka hanana holoʻokoʻa a me ka hana o ka lolo. ʻOiai ʻo ka ʻeha mau e alakaʻi i kēia mau mea, i waena o nā pilikia olakino ʻē aʻe, ʻo ka mālama kūpono ʻana i nā ʻōuli paʻa o ka mea hoʻomanawanui hiki ke hoʻohuli i nā loli o ka lolo a hoʻoponopono i nā mea hina. Eia kekahi, ua nui a nui nā noiʻi noiʻi i puka ma hope o ka mea nui o ka ʻōnaehana endocannabinoid a he hana ia i ka kaohi ʻana a me ka mālama ʻana i ka ʻeha mau a me nā pilikia olakino ʻē aʻe. ʻIke ʻia mai ka National Center for Biotechnology Information (NCBI). "Ka palena o kā mākou ʻike i kaupalena ʻia i ka chiropractic a me nā hōʻeha a me nā kūlana spinal. E kūkākūkā i kēia kumuhana, e ʻoluʻolu e nīnau iā Dr. Jimenez a i ʻole e leka uila iā mākou ma915-850-0900 .

 

Hoʻopūʻia e Dr. Alex Jimenez

Green-Call-Now-Button-24H-150x150-2-3.png

Nā Pāhana Hou: Back Pain

Paʻi hope ʻo ia kekahi o nā kumu nui loa o ka hemahema a ua hala nā lā ma ka hana ma ka honua holoʻokoʻa. ʻOiai he meaʻoiaʻiʻo, ua hoʻokauʻia kaʻeha hope ma keʻano he kumu kumuʻelua no ka heleʻana o ke keʻena o ke kauka,ʻoi aku ma mua wale nō nā maʻi āpau kiʻekiʻe. Ma kahi o 80 pakeneka o ka heluna eʻike i kekahiʻano o kaʻeha hope loa ma kahi o hoʻokahi manawa ma ko lākou ola. ʻO ka'ōiwi kahi hanana paʻapū i hanaʻia i ka iwi, nā hono, nā ligaments a me nāʻiʻo, i waena o nā mea'ē aʻe. Ma muli o kēia, nāʻeha a me nā kūlana hōʻeha, e like me nā kīlei'aniani, hiki ke hopena i nā hōʻailona o ke kaumaha hope. ʻO nāʻeha a me nāʻeha a me nā pōpilikia pū kaʻa paha he kumu pinepine ia o kaʻehaʻeha, akā, i kekahi manawa,ʻoi aku kaʻoi loa o nā hana i loaʻa i nā hopenaʻeha. ʻO ka mea pōmaikaʻi, hiki i nā koho hoʻoponopono'ē aʻe, e like me ka mālamaʻana i ka chiropractic, ke kōkua i ka pale i kaʻeha ma o ka hoʻohanaʻana i nā hoʻololiʻana o ka'ōpū a me nā lima lima, me ka hoʻomaikaʻi maikaʻi i nā maʻi.

 

 

 

blog blog of hawaiian cartoon big news

 

KA HOʻOPIʻI MANAʻO KAULAHI: Ke Kūlana Paena Paʻi Loa

 

Nā ʻ Mlelo Aʻe: EXTRA EXTRA: ʻChronic Pain & Treatments

 

Palena
E hoʻomaopopo '
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2. Flor H, Nikolajsen L, Staehelin Jensen T (2006)�ʻO ka ʻeha o ka lālā Phantom: kahi hihia o ka maladaptive CNS plasticity?Nat Rev Neurosci7: 873–881.�[Hoʻokuʻuʻia]
3. Wrigley PJ, Gustin SM, Macey PM, Nash PG, Gandevia SC, a me al. (2009)�ʻO nā hoʻololi anatomical i ka cortex kaʻa kanaka a me nā ala kaʻa ma hope o ka hōʻeha ʻana i ka spinal cord. Cereb Cortex19: 224–232.�[Hoʻokuʻuʻia]
4. Mei A (2008)�Hiki ke hoʻololi i ke ʻano o ka lolo ka ʻeha mau. Pain137: 7–15.�[Hoʻokuʻuʻia]
5. Mei A (2009) Morphing voxels: ka hype e pili ana i ke kiʻi kiʻi o nā maʻi maʻi poʻo. Ka lolo.[Hoʻokuʻuʻia]
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34. Teutsch S, Herken W, Bingel U, Schoell E, Mei A (2008)�Hoʻololi i ka lolo hina ma muli o ka hoʻoulu hou ʻana i ka ʻeha. ʻO Neuro42: 845–849.�[Hoʻokuʻuʻia]
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36. Flor H, Denke C, Schaefer M, Grusser S (2001)�Ka hopena o ka hoʻomaʻamaʻa hoʻokae sensory ma ka cortical reorganization a me ka ʻeha phantom limb. Lancet357: 1763–1764.�[Hoʻokuʻuʻia]
37. Swart CM, Stins JF, Beek PJ (2009)�ʻO nā hoʻololi cortical i ka complex regional pain syndrome (CRPS). ʻO'Eur J Pain13: 902–907.�[Hoʻokuʻuʻia]
38. Maihofner C, Baron R, DeCol R, Binder A, Birklein F, a me al. (2007)�Hōʻike ka ʻōnaehana kaʻa i nā loli adaptive i ka maʻi ʻeha ʻāpana āpau. Brain130: 2671–2687.�[Hoʻokuʻuʻia]
39. Fontaine D, Hamani C, Lozano A (2009)�ʻO ka maikaʻi a me ka palekana o ka hoʻoulu ʻana i ka cortex motor no ka ʻeha neuropathic mau loa: ka loiloi koʻikoʻi o ka palapala. J Neurosurg110: 251–256.�[Hoʻokuʻuʻia]
40. Levy R, Deer TR, Henderson J (2010)�Intracranial neurostimulation no ka mālama ʻana i ka ʻeha: kahi loiloi. Uku Lapaʻau13: 157–165.�[Hoʻokuʻuʻia]
41. Antal A, Brepohl N, Poreisz C, Boros K, Csifcsak G, a me al. (2008)�ʻO ka hoʻoulu ʻana o ka transcranial i kēia manawa ma luna o ka somatosensory cortex e hoʻemi ana i ka ʻike ʻeha ʻeha i hoʻokolohua ʻia.. Clin J Pain24: 56–63.�[Hoʻokuʻuʻia]
42. Teepker M, Hotzel J, Timmesfeld N, Reis J, Mylius V, a me al. (2010)�ʻO ka rTMS haʻahaʻa haʻahaʻa o ka vertex i ka mālama prophylactic o ka migraine. ʻO Cephalalgia30: 137–144.�[Hoʻokuʻuʻia]
43. O�Connell N, Wand B, Marston L, Spencer S, Desouza L (2010)�Nā ʻenehana hoʻoulu ʻana i ka lolo no ka ʻeha mau. He hōʻike o kahi loiloi ʻōnaehana Cochrane a me ka meta-analysis. ʻO Eur J Phys Rehabil Med47: 309–326.�[Hoʻokuʻuʻia]
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Pani ʻApono
ʻO ke kelekemaʻana o ka maʻi

ʻO ke kelekemaʻana o ka maʻi

ʻO ka mea maʻamau o ka maʻi:- Loaʻa i nā syndrome ʻeha āpau kahi pilikino. Hiki ke loli ke ʻano pilikino mai kahi kanaka a kahi kanaka a hiki ke ʻokoʻa i hoʻokahi kanaka i nā manawa like ʻole. ʻO ka mālama ʻana i nā syndrome ʻehaʻeha e hoʻomaopopo i kēia pilikino mumū. Lapaʻau ʻia nā syndrome ʻeha me ka lāʻau, ʻokiʻoki a ʻelua paha. ʻO ka pahuhopu e pāpā / kāohi i ka hana o nā mea hoʻolauna uila. A ʻo kahi hopena kūleʻa kahi hopena i ka liʻiliʻi o ka mumū a ʻoia hoʻi ka liʻiliʻi o ka ʻeha.

ʻO ke kelekemaʻana o ka maʻi

Nń Pahuhopu:

  • ʻO wai nā mea pāʻani nui
  • He aha nā mea kanu lāʻau?
  • He aha nā hopena?

Hōʻuluʻulu Uila:

Key Players

ka lāʻauʻona maʻaola o pain el paso tx.

ka lāʻauʻona maʻaola o pain el paso tx.

ka lāʻauʻona maʻaola o pain el paso tx.

ka lāʻauʻona maʻaola o pain el paso tx.No ke aha e ʻeha ai koʻu poʻohiwi? ʻO kahi loiloi o ke kumu Neuroanatomical & Biochemical o ka ʻeha poʻohiwi

KANAWAI

Inā nīnau ka mea maʻi "no ke aha e ʻeha ai koʻu poʻohiwi?" E huli koke ke kamaʻilio i ka ʻepekema ʻepekema a i kekahi manawa ke kuhi hewa ʻole. ʻO ka manawa pinepine, ʻike ka mea lapaʻau i nā palena o ke kumu ʻepekema o kā lākou wehewehe ʻana, e hōʻike ana i ka piha ʻole o ko mākou ʻike i ke ʻano o ka ʻeha o ka poʻohiwi. Lawe kēia loiloi i kahi ʻōnaehana e kōkua i ka pane ʻana i nā nīnau nui e pili ana i ka ʻeha o ka poʻohiwi, me ka manaʻo e hāʻawi i ka ʻike i ka noiʻi e hiki mai ana a me nā ʻano novel no ka mālama ʻana i ka ʻeha o ka poʻohiwi. E ʻimi mākou i nā kuleana o (1) nā peripheral receptor, (2) ka hana ʻeha ākea ākea a i ʻole ka "neociceptia", (3) ka iwi kuamoo, (4) ka lolo, (5) kahi o nā mea loaʻa i ka poʻohiwi a me (6 ) ke neural anatomy o ka poʻohiwi. E noʻonoʻo pū mākou pehea e kōkua ai kēia mau mea i ka loli i ka hōʻike maʻi, ka hōʻailona a me ka mālama ʻana i ka ʻeha o ka poʻohiwi. Kuhi mākou i kēia ala e hāʻawi i kahi nānā o nā ʻāpana o ka ʻōnaehana ʻike ʻeha ākea a me nā hana hana ʻeha waena i ka ʻeha poʻohiwi e launa pū e hana i ka ʻeha maʻi.

INTRODUCTION: HE HISTORI HOLOHOLO KAULIʻO PAʻIA PA'ĀINA ESSENTIAL PALAPALA I NĀ KININI

ʻO ke ʻano o ka ʻeha, ma ke ʻano nui, he kumuhana o nā hoʻopaʻapaʻa i hala i ke kenekulia i hala. I ka kenekulia 17 Descartes 'i manaʻo ʻia e ka manaʻo1 ua pili pono ka ikaika o ka ʻeha i ka nui o ka ʻeha pili a pili ʻia ka ʻeha ma hoʻokahi ala ʻokoʻa. Ua hilinaʻi nui ʻia nā manaʻo mua e pili ana i kēia kālaiʻike Descartian i kapa ʻia ʻo "Dequistian", ke ʻike nei i ka ʻeha ma ke ʻano he hopena o ka hoʻonāukiuki ʻana i kahi mea ʻehaʻeha maʻi maʻi i loaʻa i ka lolo. I ke kenekulia 20 ua hoʻoili ʻia kahi kaua ʻepekema ma waena o ʻelua mau manaʻo kūʻē ʻē aʻe, ʻo ia hoʻi ke kumumanaʻo kikoʻī a me ke kumumanaʻo kumumanaʻo. ʻO ka Descartian "ke kumumanaʻo kikoʻī" i ʻike i ka ʻeha ma ke ʻano he kaʻawale kūikawā o ke komo ʻana o ka sensory me kāna mea pono ponoʻī, ʻoiai ke kumumanaʻo Teltern i manaʻo ʻia ka ʻeha ma muli o ka hoʻonāukiuki nui o nā mea loaʻa ʻole kikoʻī. 2 I ka makahiki 1965, Wall a me Melzack ʻO ke kumumanaʻo o ka ʻeha o ka ʻīpuka i hōʻike ʻia no kahi hiʻohiʻona i hoʻololi ʻia ai ka ʻike ʻeha e nā manaʻo sensory ʻelua a me ka ʻōnaehana waena. ʻO kekahi holomua nui loa i ka ʻatikala ʻeha ma kahi o ka manawa like i ʻike ʻia i ke ʻano kikoʻī o nā hana o nā opioids.3 Ma hope iho, ua hoʻonui nui nā neʻe hou ʻana i ka neuroimaging a me nā lāʻau lapaʻau molekiola i ko mākou ʻike āpau i ka ʻeha.

No laila pehea e pili ai kēia i ka ʻeha o ka poʻohiwi?ʻO kaʻehaʻeha ka hopena maʻamau, a me ka ʻike ikaika i ke ʻano o ka hana ʻia ʻana o ka ʻeha e ke kino e pono ai e ʻike pono a mālama i ka ʻeha o ka mea maʻi. ʻO ka holomua i ko mākou ʻike i ka hana ʻeha e hoʻohiki e wehewehe i ka like ʻole ma waena o nā pathology a me ka ʻike o ka ʻeha, hiki iā lākou ke kōkua iā mākou e wehewehe i ke kumu e pane ʻole ai kekahi mau maʻi i kekahi mau ʻano lapaʻau.

KA BUʻU LĀKĀ PALAPALA O PAIN

Nā mīkini ʻikepili peripheral sensory: ka mīkini ʻenekini a me ka "nociceptor"

Nui a hewahewa nā ʻano like ʻole o nā resepera sensory peripheral i loko o ka ʻōnaehana musculoskeletal kanaka. 5 Hoʻonohonoho ʻia lākou e pili ana i kā lākou func tion (ma ke ʻano o ka mechanoreceptors, thermoreceptors a i ʻole nociceptors) a i ʻole morphology (nā hopena aʻa manuahi a i ʻole nā ​​ʻano ʻelima o nā recepaps encapsulated) .5 Hiki ke hoʻokaʻawale hou ʻia nā ʻano ʻokoʻa o ka receptor ma muli o ka ke kūʻana o kekahi mau kaha kemika. Aia kekahi mau overlaps koʻikoʻi ma waena o nā papa hana like o ka receptor, no ka laʻana

Ka hana ʻeha ʻana o peripheral pain

Hoʻopili ka ʻeha i nā ʻano like ʻole i nā mea ʻimi hoʻopunipuni e hoʻokuʻu ʻia e nā ʻino i hōʻino ʻia e like me bradykinin, histamine, 5-hydroxytr Egyptamine, ATP, nitric oxide a me kekahi mau ion (K + a me H +). ʻO ka hoʻoulu ʻana o ke ala waikawa arachidonic e alakaʻi aku ai i ka hana ʻana o prostaglandins, thromboxanes a me leuko- trienes. ʻO Cytokines, me nā interleukins a me nā tumros necrosis factor?, A me nā neurotrophins, e like me ke kumu ulu o ke aʻalolo (NGF), hoʻokuʻu ʻia a pili pū i ka hana o ka mumū. 15 ʻO kekahi mau mea e like me nā acid amino excitatory (glutamate) a me nā opioids ( endothelin-1) ua hoʻopili ʻia i loko o ka pane o ka mumū koʻikoʻi.16 17 Hiki paha i kekahi o kēia mau ʻākena ke hoʻoulu pololei i nā nociceptors, ʻoiai e lawe ana kekahi i ka hoʻopaʻa ʻana o nā pūnaewele ʻē aʻe a laila e hoʻokuʻu hou i nā mea kōkua maʻalahi.18. o nā neurons nociceptive i kā lākou hoʻokomo maʻamau a / a i ʻole ka hoʻopaʻa ʻana i kahi pane i nā hoʻokomo subthreshold maʻamau i kapa ʻia ʻo "sensitization āpau". - ʻO ke kiʻi 1 hōʻuluʻulu i kekahi o nā ʻano hana i pili.

ka lāʻauʻona maʻaola o pain el paso tx.ʻO ka NGF a me ka receptor transient Loaʻa cation subfamily V lālā 1 (TRPV1) i loaʻa kahi pilina simbiotic i ka wā e pili ana i ka mumū a me ka noʻonoʻo ʻana i ka nociceptor. ʻO nā cytokine i hana ʻia i loko o nā mea āpau i hopena i ka hoʻonui ʻana o ka hana NGF. 19 stimole ʻo NGF i ka hoʻokuʻu ʻia o histamine a me serotonin (5-HT3) e nā cell mast, a me nā sensitizes no neoicic, e hoʻololi paha i nā waiwai o A? nā olonā e like me ka hapa nui i lilo i nociceptive. Aia ka receptor TRPV1 i kahi subpopulation o nā fibre afferent mua a hoʻoulu ʻia e capsaicin, ka wela a me nā protons. Hoʻohui ʻia ka receptor TRPV1 i loko o ke kino o ke olonā afferent, a lawe ʻia i nā kikowaena peripheral a me nā kikowaena waena, kahi e hāʻawi ai i ka ʻike i ka poʻe i loaʻa ʻole i ke aloha. Nā hualoaʻa ka hopena o ka NGF hana peripherally a laila paʻa i ka tyrosine kinase receptor type 1 receptor ma nā kikowaena nociceptor, a laila lawe ʻia ʻo NGF i ke kino pūnaewele kahi e alakaʻi ai i kahi rula o TRPV1 transcription a no laila ua hoʻonui i ka noʻonoʻo nociceptor.19 20 NGF a ʻo nā mea uwao hoʻonāukiuki ʻē aʻe e hoʻomaopopo iā TRPV1 ma o ka lehulehu o nā ala ʻelele ʻelua. Manaʻo ʻia nā mea ʻē aʻe he nui e like me nā cholinergic receptor,? -Aminobutyric acid (GABA) a me nā mea loaʻa somatostatin e pili pū ana i ka ʻike o ka nociceptor peripheral.

Ua hoʻokomo kikoʻī ʻia kahi helu nui o nā mea waena hoʻohauna i ka ʻeha o ka poʻohiwi a me ka maʻi rotator. Pili paha kēia mau loli i ka unuhi a i ʻole ka lohi ʻana o ka transcription dependant. ʻO nā laʻana o ka mea mua he mau loli i ka TRPV21 receptor a i ʻole nā ​​kahawai ion gated voltage i hopena ʻia mai ka phosphorylation o nā protein i hoʻopaʻa ʻia e ka membrane. ʻO nā laʻana o ka hope e pili ana me ka hoʻonui ʻana o NGF i ka hana TRV25 a me ka hoʻoulu ʻia ʻana o ka calcium i nā kumu transcript intracellular.

Nā Molecular Mechanisms Of Nociception

Hoʻomaopopo ka manaʻo o ka ʻeha iā mākou i kahi ʻeha maoli a i ʻole e hōʻeha ʻia ana a hoʻonāukiuki i nā pane pale kūpono. Minamina, ʻoi aku ka nui o ka ʻeha i kona pono ma ke ʻano he ʻōnaehana a laila lilo i wā lōʻihi a hoʻonāwaliwali hoʻi. ʻO kēia hoʻololi i kahi pae mau e pili ana i nā loli i loko o ka iwi kuamoo a me ka lolo, akā aia kekahi modulate kupaianaha kahi e hoʻomaka ai nā leka ʻeha ma ke kiʻekiʻe o ka neuron sensory mua. ʻO nā hana e hoʻoholo ai pehea e ʻike ai kēia mau neo i nā mea hoʻonāukiuki i hana ʻia o kahi mehana, mechanical a kemikala paha i hōʻike i nā ʻōnaehana hōʻailona hou a hoʻokokoke iā mākou i ka hoʻomaopopo ʻana i nā hanana molekole e kōkua ai i ka hoʻololi mai ka ʻeha a ʻeha mau.

ka lāʻauʻona maʻaola o pain el paso tx.ʻO ke Neurochemistry Of Nociceptors

ʻO Glutamate ka pahuhopu nui o nā neurotransmitter i nā mea holoʻokoʻa. Ma kaʻikeʻana o ka neʻeneʻeʻana o C to DRG, hōʻikeʻia nā'ōwiliʻelua o ka fiʻiliʻi C nonmyelinated.

ʻO nā mea kelepa o ka mea kelepa e hana i ka pōʻino

E like me ia i ho'ākākaʻia ma luna nei, hoʻonui ka hōʻeha i ko mākou hopena o kaʻeha ma ka hoʻonuiʻana i kaʻike o nā mea nociceptors i nā kauā a me nā mechanical. ʻO kēia hualoaʻa he hopena, ma ka hapa, mai ka hana a me ka hoʻokuʻuʻana o nā mea keleponaʻenehana mai ke kumu pūnaehana mua a mai nā pūniki neuralʻole (e like me ka fibroblasts, nā mast cells, neutrophils and platelets) i ka environnement36 (Fig 3). Hiki i kekahi mau mea o ke kōpala inflammatory (e like me nā protons, ATP, serotonin, aiʻole lipids) ke hoʻololi i ke kuhi kūpono pololei ma o ke kuhiʻana i nā kaha moana ma ka'āpana nociceptor, akāʻo nā mea'ē aʻe (e like me ka bradykinin a me ka NGF) e hoʻopili i ko lākou hopena ma ka hoʻounaʻana i ka cascades11 hōʻailona lua. Uaʻike nuiʻia ka holomua o kaʻikeʻana i ke kumuhana biochemistry o kēlā me kēia hana.

Nā Extrasellular Protons & Tissue Acidosis

ʻO ka acidosis tissue āpau o keʻano o kaʻeleʻele physiological i nā hōʻeha, a me ka lōʻihi o kaʻeha a me ka pilikiaʻole e pili pono ana me ka nui o acidification37. ʻO ka hoʻohanaʻana i ka waikawa (pH 5) i kaʻili, ua hoʻomauʻia ka hoʻokuʻuʻiaʻana i kahiʻekolu aʻoi aku paha o nā mea hanaʻole polymodal e hoʻokipa ana i ka mākau hoʻolālā 20.

ka lāʻauʻona maʻaola o pain el paso tx.Nā Pūnaewele Mole & Molecular Of Pain

Hōʻuluʻulu Manaʻo

Keʻike a hoʻohālikelike ke kikowaena i nā hanana a me nāʻoihana likeʻole a me keʻano o nā meaʻona. I ka wā nui, kēia mau kumuhana e loaʻa ai kaʻeha nui, a ma ke kauʻana o nā hōʻeha kūpilikiʻi, nāʻaoʻaoʻelua a me nā kikowaena pūnaewele o ke ala o ke kahe e hōʻike ana i ka'ilikala nui, hoʻonui i nā hōʻailona o kaʻeha a me ka hanaʻana i ka haʻikoʻi. Ke hoʻololi ka'ilika i nā palekana palekana, hiki iā ia ke pōmaikaʻi, akā, i ka wā e hoʻololi ai nā loli, hiki ke hopena i ka hopena o ka maʻi. ʻO nā haʻawina pilikino,ʻikepili, a me nā haʻawina pharmacological ke hoʻokiʻekiʻe nei i nā hana molekino e hoʻomanaʻo i kaʻike, coding, a me ka hoʻololiʻana o nā hopena hōʻeha e hoʻopiʻi i kaʻeha.

'Ōlelo Ho'ākāka: Hōʻailona Pōʻino i ka Paʻa Palolo

ka lāʻauʻona maʻaola o pain el paso tx.

ka lāʻauʻona maʻaola o pain el paso tx.Hōʻike 5. ʻO ke kōlani'Ākau (Central) Manaʻo

  1. Glutamate / NMDA hoʻokipaʻana i ka hanana.Ma hope o ka hoʻonāukiuki ikaika a i ʻole ʻeha mau, hana ʻia ʻo C a me A? hoʻokuʻu nā nociceptors i nā ʻano like ʻole o nā neurotransmitters e like me ka dlutamate, ka mea P, ka helu helu e pili ana i ka peptide (CGRP), a me ATP, i nā neurons puka ma lamina I o ka pepeiaohao dorsal (ʻulaʻula). Ma muli o ka hopena, hiki i nā mea loaʻa NMDA glutamate hamu maʻamau ke kau ʻia i loko o ka neuron postynaptic i kēia manawa ke hōʻailona, ​​hoʻonui i ka calcium intracellular, a hoʻoulu i kahi ala o nā ala kalina hōʻailona kalina a me nā ʻelele ʻelua e pili pū ana me ka kinase protein (MAPK) i hoʻokumu ʻia me ka mitogen-activated protein kinase C (PKC) , protein kinase A (PKA) a me Src. E hoʻonui kēia cascade o nā hanana i ka pīhoihoi o ka neuron puka a kōkua i ka lawe ʻana o nā leka ʻeha i ka lolo.
  2. ʻO ka hōʻinoʻana.N Ma lalo o nā kūlana maʻamau, hoʻokuʻu mau ka interneurons (polū) i ka GABA a me / a i ʻole glycine (Gly) e hoʻoliʻiliʻi i ka hauʻoli o ka lamina I nā neurons a hoʻohālikelike i ka lawe ʻana o ka ʻeha. Eia nō naʻe, i ke kau ʻana o ka ʻeha, hiki ke lilo i kēia kaohi ʻana, a laila hopena i ka hyperalgesia. Hoʻohui ʻia, hiki i ka disinhibition ke hoʻohana i ka myelinated A non-nociceptive? nā mea i kauoha mua e komo i ka circuitry transmission painry e like me ka mea i ʻike pinepine ʻia nā stimulus ʻino ʻole i kēia manawa he ʻeha. Kū kēia i kahi ʻāpana, ma o ka disinhibition o PKC pīhoihoi? ke hōʻike nei i nā interneurons i loko o lamina II.
  3. Hoʻopauʻia ka Microglial.Hāpai ka ʻehaʻeha pilikino i ka hoʻokuʻu ʻia o ATP a me ka chemokine fractalkine e hoʻoulu ai i nā hunaola microglial. Ma ke kikoʻī, ka hoʻoulu ʻana o purinergic, CX3CR1, a me nā mea loaʻa like me Toll i ka microglia (poni) nā hopena i ka hoʻokuʻu ʻia ʻana o ka mea neurotrophic i loaʻa i ka lolo (BDNF), ma o ka hoʻoulu ʻia ʻana o nā mea loaʻa TrkB i hōʻike ʻia e lamina I nā neurons puka, paipai i ka hoʻonui i ka excitability a me hoʻonui i ka ʻeha i ka pane ʻana i ka hoʻonāukiuki noxious a me nā hala ʻole (ʻo ia hoʻi, hyperalgesia a me allodynia). Hoʻokuʻu pū ka microglia i hoʻoiho ʻia i kahi pūʻulu o cytokines, e like me ka tumrosis tumor factor? (TNF?), Interleukin-1? a me 6 (IL-1 ?, IL-6), a me nā kumu ʻē aʻe e hoʻopili i ka sensitization waena.

ʻO ke KauponaʻOihana Hila

Peripheral sensitization ʻoi aku ka nui o nā hopena mai nā loli e pili ana i ka mumū ma ke ʻano kemika o ke olonā nerve (McMahon et al., 2008). No laila, hui pū ʻia ka hōʻino kino me ka hōʻiliʻili o nā mea endogenous i hoʻokuʻu ʻia mai nā nociceptors i hoʻoneʻe ʻia a i ʻole nā ​​neural non-neural e noho i loko a i ʻole infiltrate i loko o ka wahi i hōʻeha ʻia (e like me nā mast mast, basophil, platelets, macrophages, neutrophil, endothelial cells, keratinocytes, a fibroblasts). Hoʻohui. kapa ʻia kēia mau mea i kapa ʻia ʻo ka «suplam inflammatory», hōʻike i ka nui o nā molela hōʻailona, ​​e like me nā neurotransmitters, peptides (mea P, CGRP, bradykinin), eicosinoids a me nā lipid pili (prostaglandins, thromboxanes, leukotrienes, endocannabinoids), neurotrophins, cytokines , a me nā chemokine, a me nā proteas extracellular a me nā proton. ʻO ka mea kupaianaha, hōʻike nā nociceptors i hoʻokahi a ʻoi paha mau ʻenekini ʻili pūnaewele hiki ke ʻike a pane i kēlā me kēia o kēia agena pro-inflammatory a pro-algesic paha (Kiʻi 4). ʻO ia mau pilina e hoʻonui i ka pīhoihoi o ke olonā nerve, no laila e hoʻonui ai i kona ʻike i ka mahana a i ʻole ka pā.

ʻO ke kumuʻole,ʻo ka hōʻailona maʻamau o ka hōʻemiʻana i kaʻehaʻeha e pili ana i ka hōʻokiʻana i ka hōʻano a me ka hōʻiliʻiliʻana o nā māhele o ke kōpū inflammatory. ʻO kēia ka maikaʻi loa o nā hōʻailona anti-inflammatory steroidal, e like me ka aspirin a me ka ibuprofen, ka mea e ho'ēmi ai i kaʻeha a me ka hyperalgesia e ka hanaʻana i nā cyclooxygenases (Cox-1 a me Cox-2) e komo ana i ka synthesis. ʻO ka lua o kaʻaoʻao,ʻo ia ke kāpae i nā hana a nā meaʻona inflammatory i ka nociceptor. Maʻaneʻi, e hoʻohālikelike mākou i nā hiʻohiʻona e hāʻawi i kaʻike hou i nā'ōnaehana pūnaewele o kaʻike pilikino, a iʻole keʻano o nā kumu hana hōʻailona no ka mālamaʻana i kaʻeha inflammatory.

No ka mea, uaʻike nuiʻia ka NGF no kona kūlana heʻano neurotropic i koiʻia no ke ola a me ka hoʻomohalaʻana i nā neo ma muli o ka embryogenesis, akā ma ke kanaka makua, ua hanaʻia ka NGF ma kahi o nā meaʻeha a me kahi mea nui o ka'ōpūʻona (Ritner et al., 2009). Ma waena o kāna mau polokalamu pūnaewele, hoʻoponopono pololeiʻo NGF i ka peptideric C fiber nociceptors,ʻo ia ka mea e hōʻike ana i ka tygine kinesa NGF nui loa, TrkA, a me ka mea liʻiliʻi neurotrophin receptor, p75 (Chao, 2003, Snider a me McMahon, 1998). Nā NGF e hoʻomaopopo i keʻano o ka hoʻomaʻamaʻaʻana i ka wela a me ka uluʻana o ke kino ma o nā hananaʻokoʻaʻelua. I ka manawa mua, hana ka hulina NGF-TrkA i ke ala o nā ala hōʻailona, ​​e like me ka phospholipase C (PLC), kinase protein kinameʻa (MAPK), a me phosphoinositide 3-kinase (PI3K). Hiki i kēia ka hopenaʻoihana o nā mea hoʻomalu i ke kikowaena nociceptor terminal, ma kahi o TRPV1, hiki i ka loli wikiwiki o kaʻikeʻana o ka wela a me ke kino (Chuang et al., 2001).

Me ka nānā ʻole i kā lākou papahana pro-nociceptive, ke keʻakeʻa ʻana me ka neurotrophin a i ʻole ka hōʻailona cytokine i lilo i kumumanaʻo nui no ka kaohi ʻana i nā maʻi ʻōpala a i ʻole ka ʻeha hopena. ʻO ke ala nui e pili ana i ka pale ʻana iā NGF a i ʻole TNF-? hana me kahi antibody hoʻoliʻiliʻi. I ka hihia o TNF-?, He hopena maikaʻi loa kēia i ka mālama ʻana i nā maʻi autoimmune he nui, e like me ka rheumatoid arthritis, a hiki i ka hoʻoliʻiliʻi nui ʻana i ka luku ʻia ʻana o nā mea ʻelua a me ka hyperalgesia e hele pū ana (Atzeni et al., 2005). Ma muli o ka hana nui o NGF ma luna o ka makua nokiceptor e hana i ka hoʻonohonoho ʻana o ka mumū, ʻo ka maikaʻi o kēia ala e hoʻoliʻiliʻi ka hyperalgesia me ka ʻole o ka hopena. ʻike ʻeha mau. ʻOiaʻiʻo, aia nā anti-NGF i kēia manawa i nā hoʻokolohua hoʻokolohua no ka mālama ʻana i nā syndromes ʻeha hōʻeha (Hefti et al., 2006).

Glutamate / NMDA Hoʻonāʻana i kaʻikeʻana

Hoʻomakaʻia kaʻeha nui ma ka hoʻokuʻuʻiaʻana o ka glutamate mai nā piko o nā nociceptors, e hoʻonui i nā kaha o ka post-synaptic (EPSC) ma ka papaʻelua i nā neurons. Hoʻoholo mua kēia ma o ka hoʻokomoʻana i ka AMPA postsynaptic a me nā subtypes kainate o nā mea loaʻa ka'āpana kamepiula. ʻO ka hōʻuluʻuluʻana o nā pūnaewele EPSC i lalo o ka paepae ma muli o ke neuron postsynaptic e hopena i ka hanaʻana i ka hana a me ka laweʻana i ka leka uila i nā koina kiʻekiʻe kiʻekiʻe.

ʻO nā haʻawina'ē aʻe e hōʻike ana i nā hoʻololiʻana o ka neuron hana,ʻo ia iho, e hoʻohui i ka kaʻina hana. Eia kekahi laʻana,ʻo ke kino o ke kino o ke kino e hoʻoponopono i ka K + - Cl-trans-conveyor KCC2, he mea nui no ka hoʻomauʻana i nā K + a me nā mea kelihi ma o ka membrane plallma (Coull et al., 2003). Ke hoʻolālāʻia neiʻo KCC2, i ho'ākākaʻia ma lamina I nā neu ua loaʻa, e hopena i kahi hoʻololi i ke Kēkelēkelē, e like me ka hoʻonāʻana o nā GABA-A hōkeo i ka hoʻopalehuʻana, ma mua aʻe o ka hyperpolarize i nā neu. ʻO kēia ka mea e hoʻonui i ka mana kūpono a me ka hoʻonui i ka paʻi. ʻO keʻano,ʻo ka hana kāpili pharmacological a iʻole i ka RNA-mediated downregulation o KCC2 i loko o ka'īlio e hoʻokomo i ka mechanic mechanic.

E hoʻokaʻawale i kahi ebook

Sources:

No ke aha e hōʻehaʻia ai koʻu poʻohiwi? ʻO keʻano no ka neuroanatomical a me ka biochemic kumu o kaʻeha o ka wāwae

ʻO Benjamin John Floyd Dean, Stephen Edward Gwilym, Andrew Jonathan Carr

Nā Pūnaewele a me nā Molecular Means o Pain

Allan I. Basbaum1, Diana M. Bautista2, Gre? Gory Scherrer1, a me David Julius3

1Department o Anatomy, Ke Kulanui o Kaleponi, San Francisco 94158

2Department o ka Molecular a me ka Cell Biology, Ke Kulanui o Kaleponi, Malena HI 94720 3Department o Physiology, Kulanui o Kaleponi, San Francisco 94158

ʻO ka hana i ka hanaʻole o ka nociception

David Julius * & Allan I. Basbaum`

*Ke Keʻena o Cellular and Molecular Pharmacology, a me �Departments of Anatomy and Physiology and WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, Kaleponi 94143, USA (e-mail: julius@socrates.ucsf.edu)

ʻO nā hiʻohiʻona o ka Pathophysiology o Neuropathic Pain

ʻO nā hiʻohiʻona o ka Pathophysiology o Neuropathic Pain

ʻO ka ʻeha neuropathic kahi maʻi paʻakikī, ʻeha mau loa e hele pū ʻia me ka ʻeha ʻili palupalu. He mea maʻamau ka ʻeha neuropathic i ka hoʻomaʻamaʻa lapaʻau a he mea paʻakikī hoʻi i nā maʻi a me nā kauka. Me ka ʻeha neuropathic, hiki ke hōʻeha ʻia nā aʻalolo ponoʻī, ʻeha a ʻeha paha. ʻO ka ʻeha neuropathic ka hopena o ka pōʻino mai ka ʻeha a i ʻole ka maʻi i ka ʻaoʻao a i ʻole ke kikowaena o ke kikowaena, kahi e hiki mai ai ka ʻeha ma nā wahi āpau. ʻO ka hopena, hiki i kēia mau aʻalolo poino ke hoʻouna i nā hōʻailona hewa i nā kikowaena ʻeha ʻē aʻe. ʻO ka hopena o ka hōʻeha ʻana i ke aʻalolo he hoʻololi i ka hana neural, ma ka ʻāpana o ka ʻeha a me ka ʻeha. ʻO nā hōʻailona hōʻailona o ka ʻeha neuropathic ka mea maʻamau e pili ana i nā hanana sensory, e like me ka ʻeha kūʻokoʻa, paresthesias a me ka hyperalgesia.

 

ʻO kaʻeha Neuropathic, e like me ia i ho'ākākaʻia e ka International Association of Study of Pain a iʻole IASP paha, ua hoʻomakaʻia kaʻeha a hanaʻia paha e ka liona mua a iʻole ka hanaʻole o ka pūnaewele maʻi. Hiki ke hopena i ka hopena ma kahi o ka neuraxis: pūnaewele puni honua, ka'ōpū, a me nā pūnaewele kahuwai supraspinal. ʻO nāʻano eʻike ai i kaʻeha neuropathic mai nāʻano'ē aʻe e like me kaʻeha a me nā hōʻailonaʻike ma hope o ka manawa ho'ōla. Hiki i ke kino o nā kānaka keʻano o ka huhū maʻamau, o ke aloha, a me kaʻike o nā mea hōʻeuʻeuʻole e like me kaʻeha, a me ka hopena, a iʻole ka hoʻomauʻana o ke ahi. ʻO kaʻeha maʻamau kaʻona o nā "wili a me nā kola", ka'a'āʻana, ka panaʻana, ka paʻiʻana a me kaʻeha paroxysmal, aiʻole ka uila-e like me kaʻeha, i pili pinepine i ka dysesthesias a me ka paresthesias. ʻO kēia mau manaʻo e hoʻololi wale i nā mea hana akamai a ka mea maʻi, akā,ʻo ka maʻi o ka maʻi, keʻano, ka nānā, a me ka noʻonoʻo. ʻO kaʻeha neuropathic no nā hōʻailona "ʻinoʻole," e like me ke kaumaha o kaʻike a me keʻano o ke kaniʻana, a me nā hōʻailona "maikaʻi", e like me ka paresthesias, kaʻeha manawaʻole a me ka hoʻonuiʻia o ka huhū.

 

ʻO nā kūlana e pili pinepine ana i kaʻeu neuropathic hiki ke heluʻia i loko o nā hui nuiʻelua:ʻeha no ka pōʻino i ka pūpū pūpū waena a me kaʻeha no ka pōʻino o ka pūnaewele puni honua. ʻO nāʻeha cortical and sub-cortical, traumatic spinal cord wounds, syringo-myelia and syringobulbia, trigeminal and glossopharyngeal neuralgias, neoplastic and other lions of space, are neuralgias. ʻO nā neuropathy maʻamau, nā neuropathies maʻamau, nā neuropathy ischemic, polyneuropathies polypeuropathies, plexopathies, kaohiʻana o ke aʻa nerve, ka maʻi hope o ka lāpili a me ka wāwae o ka lālā, nā neuropathies posthelpetic a me nā neuropathies e pili ana i ka maʻi.

 

ʻO ka Pathophysiology o Neuropathic Pain

 

ʻO nāʻano hana pathophysiologic a me nā manaʻo e pili ana i nāʻeha neuropathic he nui. Ma mua o ka uhi 'ana i kēia mau hana, he mea koʻikoʻi ka loiloi' ana i nā kelepona 'eha. ʻO nā kaʻaʻehaʻeha e pili ana i ka hoʻoukaʻana o kahi nociceptor, iʻikeʻia hoʻi he diapena maʻi, ma ka paneʻana i ka hoʻonaniʻeha. Hoʻokomoʻia ka hawewe o ka depolarization i nā lālani mua, me ka puluma e holo ai i loko o nā pūnaehu sodium a me ka lepo pālolo. ʻO nā neurons e hoʻopau i ka lolo ka mea i loko o ka pū'ālua poʻoʻole aiʻole i ka pepeiaohao o ka'ōpū. Aia maanei kahi i kau ai ka hōʻailona i nā kahawai calcium voltage-volted in the pre-synaptic terminal, e hiki ai ke kāpili e komo. ʻO ka punaʻai ka mea glutamate, kahi neurotransmitter excitatory, e hoʻokuʻuʻia i loko o ka synaptic. Hāweleʻia ka Glutamate i nā nīkia NMDA ma nā neuronua lua-ʻelua, e hoʻonui i ka depolarization.

 

ʻO kēia mau neurons e hele i waena o ke kaulahemo a hele a hiki i ka thalamus, kahi iʻike ai lākou i ka hōʻailona me keʻanoʻekolu o nā neuronui. Hoʻopili kēia mau mea i ka'ōpana limbic a me ka hamo o kaʻoki. Aia kekahi ala pākuʻi e hiki ai ke pale i ka hōʻailona hōʻailona mai ka pū kani. ʻO nā neu a me nā mea hōʻailona neʻeneʻe e puka mai i ka lolo a hele lākou i lalo i kaʻeha o ka'ōpū i kahi o lākou iʻike ai me nā'ōpiopio liʻiliʻi i ka pū kani ma ka hoʻokuʻuʻana i ka dopamine a me ka norepinephrine. Hiki i nā internalurons ke hoʻololi i ka hanana ma waena o ka lālani kauoha mua a me ka neoronui lua ma ka hāʻawiʻana i ka amino butyric acid, a iʻole GABA, he neurotransmitter inhibitory. No laila, ka hopena o kaʻeha ka hopena o ka hanaʻana i nā synapses ma waena o ka lā mua a me ka lua o nā neurons,ʻoiai ka hoʻouluʻana o ka paona ka hopena o ka hoʻopauʻana i nā pilina synaptic inhibitory.

 

ʻO ka pathophysiology o ka Neuropathic Pain Diagram | ʻO El Paso, TX Chiropractor

 

Akā,ʻaʻole i maʻalahi keʻano o ke kaumaha o ke neuropathic neuropathic. Ua hōʻikeʻia kekahi mauʻano holoholona i ka nui o nā hana. Eia naʻe, pono e hoʻomanaʻo kekahi i nā mea pili i nā mea i hanaʻoleʻia e pili mau i nā kānaka. Hiki i nā neuronui mua ke hoʻonui i ka puhiʻana i ka lāʻau inā e hoʻopauʻia kekahi hapa a hoʻonui i ka nui o nā kahe sodium. ʻO nā hopena ectopic nā hopena o ka hoʻopauʻana i ka hoʻopalekanaʻana ma kekahi mau wahi o ka fiber, e hopena ai i kaʻeha manawaʻole a me ke kaumaha e pili ana i ka hana. Hiki ke hoʻemiʻia nā kaʻina hana pāpālua ma kaʻanuʻu o ka pepeiaohao poʻo nā pūpū pūpū o ka lolo, a me nā mea'ē aʻeʻelua, e hoʻokuʻuʻia nā pilikia o kaʻeleʻele e weheʻoleʻia.

 

Eia kekahi, hiki ke hoʻololiʻia i ka hana maʻamau o kaʻeha, no ka nui o kaʻeha a me ka hoʻohanaʻana i kekahi lāʻau lapaʻau a me nā lāʻau lapaʻau, hiki i nā neuronsʻelua a meʻekolu ke hana i kahi "hoʻomanaʻo" o kaʻeha a lilo i meaʻike. Aia i laila kaʻike nui o nā neurons spinal and the threshold activation thresholds. ʻO kekahi kumu e hōʻike ana i ka manaʻo o ke kaumaha neuropathic. Ua hōʻikeʻia kēia manaʻo ma muli o ka analgesia ma hope o ka sympathecomy mai nā holoholona a me nā kānaka. Eia nō naʻe, hiki ke hoʻohui pūʻia nā mechanics i loko o nā neuropathic maʻamau a me nā maʻi neuropathic. Ma waena o kēlā mau ho'āʻo ma ka pāʻeha, aʻoi aku ka nui o nā mea e pili ana i ka maʻi neuropathic,ʻo ia ka mea hiki ke nānā aku. ʻElua mau'āpana i kēia: mua, ka heluʻana i ka maikaʻi, ka ikaika a me ka holomua; aʻo ka lua, e hōʻike pololei ana i kaʻeha neuropathic.

 

Aia nō naʻe, kekahi mau mea hōʻailona e hiki ai ke kōkua i nā kākiko i ka loiloiʻana i kaʻeha neuropathic. No nā mea hoʻomaka, ke aʻoʻana i nā koho me kaʻike ponoʻole-ʻike i ka nui o ka pōʻino o nā meaʻikeʻole, akā,ʻaʻole iʻole nā ​​alahele, nā ala e nānā i nā pane neurophysiological i nā hiku. Hoʻohui hou, nāʻikepili heluʻikepili quantitative i ka hopena i nā hopena o waho o ka hoʻololiʻana i ka hopena ma o ka hoʻonāʻana i kaʻono i kaʻili. Hoʻonuiʻia kaʻikeʻana i nā kūkuhi i nā mea hana kūikawā, e like me ka lauoho von Frey, ka pinicrick me nā nila e hoʻopili ai, a me ka hilinaʻi i ka vibration me nā vibrameters a me ka mamae wela me nā wela.

 

He mea nui loa hoʻi e hana i kahi hoʻolālā neurola maʻamau eʻike ai i ka mahuka o ka makani, nā kinona, a me nā hoʻowalewale. I ka pae hope loa, he nui nā nīnau noiʻi i hoʻohanaʻia eʻike i ke kaumaha neuropathic i kaʻehaʻeha. ʻO kekahi o lākou e komo i nā nīnau ninaninau (e like me ka Neuropathic Questionnaire a me ka ID Pain), aʻo nā mea'ē aʻe e hoʻopaʻa i nā nīnau a me nā hōʻailona kino (e like me ka hōʻailona Neuropathic Symptic and Signs scale). Pain, kahi huiʻeono mau nīnau nīnau a me nā hoʻolālā physical.

 

Paʻi Paʻi Neuropathic Paena | El Paso, TX Chiropractor

 

Nā Kūʻai Hana no ka Neuropathic Pain

 

Hoʻolālā kūpono ka Pharmacological i nā hana o kaʻeha neuropathic. Eia nō naʻe,ʻo nā mākoko pharmacologic a me nāʻoihana non-pharmacologic e hoʻopakele i ka hoʻopiha piha a'āpana paha ma kahi o ka hapalua o nā maʻi. He nui nā hōʻikeʻike e pili ana i nā hōʻike e hōʻike ana i ka huiʻana i nā lāʻau lapaʻau a me nā lāʻau lāʻau e hoʻohana ai no nāʻano hana likeʻole. ʻO ka hapanui o nā haʻawina ua huli nuiʻia i nā neuralgia post-herpetic a me nā neuropathies diabetic diabetic, akāʻaʻole paha e pili nā hualoaʻa i nā maʻi a pau neuropathic.

 

Nā hōʻaihopiho

 

Hoʻonui nā kinonapili i ka serotonin synaptic a me nāʻano norepinephrine, no laila e hoʻonui ai i ka hopena o ka pūnaewele analgesic iho e pili ana i kaʻeha neuropathic. ʻO lākou ka mea nui o ka maʻi neuropathic pain pain. Hiki paha i nā hana a me ka adrenaline ke pale aku i ka huki houʻana, a me ka hoʻopiliʻana i ka hoʻopiʻiʻana o ka dopamine, hiki ke hoʻokuʻuʻia ka'āpana NMDA-receptor a me ka pahukū. Nā kuhumu'āpana Tricyclic, e like me TCAs; no ka mea, amitriptyline, imipramine, nortriptyline a me doxepine, he ikaika i ka hoʻomau mau a me ka hōʻeha i kaʻeha me ke kaumaha maʻamau.

 

Ua hōʻoia nuiʻia nā antidepressic Tricyclic no ke kaumaha o ka neuropathic ma mua o nā kikowaena huki hou o ka serotonin, a SSRI paha, e like me fluoxetine, paroxetine, sertraline a citalopram. ʻO ke kumu paha e keʻakeʻa ai lākou i ka hopena o ka serotonin a me ka epinephrine,ʻoiaiʻo SSRI wale wale nō e hoʻonā i ka hukiʻi hou o ka serotonin. Hiki i nā'āpana antigplic antigplicers ke loaʻa nā hopena o ka maikaʻiʻole, e like me ke kausea, ka hoʻopiʻi, ka papa hoʻonele i ka naʻau, kachycardia a me nā arrhythmias ventricular. Hiki iā lākou ke hana i ka waiwai waiwai, ka pae palena a me ka hāpaiʻana o nā kothostatic. Pono e hoʻohana ponoʻia nā Tricyclic me ka mālama i ka poʻeʻelemakule, ka mea i maʻalahi i ko lākou mau hopena hopena. Pono e nānāʻia ke kauʻana o ka lāʻau lapaʻau i loko o ke koko e pale i ka hōʻinoʻia i nā maʻi i hoʻomolo i nā mīkini metabolizers.

 

ʻO nā mea hōʻeuʻeu hoʻohālike Serotonin-norepinephrine, aiʻole SNRI, he papa hou o nā antidepressants. E like me ka TCA, makemake lākou eʻoi aku ka maikaʻi ma mua o SSRIs no ka hanaʻana i kaʻeha neuropathic no ka mea e pāpālua i ka hopena o nā meaʻelua a me ka epinephrine a me ka dopamine. He mea kūpono ka Venlafaxine i nā polyneuropathies i hoʻopiliʻia, e like me ka neuropathy diabetic maʻi, e like me ka hoʻomaʻamaʻaʻana, i ka heluʻana o TCA, a uaʻoi aku ka nui o kaʻelua ma mua o ka placebo. E like me nā TCA, ua manaʻo nā SNRI e hāʻawi i nā pono kūʻokoʻa mai kā lākou hopena antidepressant. ʻO nā hopena e pili ana i ka hoʻolālā, ka hilahila, ka piʻiʻana, a me ka hōʻaloʻana.

 

ʻO nā lāʻau'alopiho Antiepileptic

 

Hiki ke hoʻohanaʻia nā lāʻau lapaʻau me keʻano mua o nā maʻi ma muli o kekahiʻano o ka maʻi neuropathic. Hana lākou i ka hoʻomehanaʻana i nā kāpili konupomi a me nā kahe sodium, ma ka hoʻonuiʻana i nā hopena hoʻopunipuni o GABA a ma ka keʻakeʻaʻana i ka hoʻouluʻana i ka excitatory glutaminergic. ʻAʻole i hōʻikeʻia nā lāʻau lapaʻau epileptic i mea e pono ai no kaʻehaʻeha. I loko o nā hihia hoʻonā lōʻihi, hoʻohanaʻia nā lāʻau'alopelo'apaʻau i ka pono wale nō i nā neuralgia. Ke hoʻohana mau neiʻo Carbamazepine i kēiaʻano. ʻO Gabapentin, ka mea e hana ai ma ke keʻakeʻaʻana i ke kelepona kōnae kaha ma waena o nā hana hanaʻino ma ka'āpana alpha-2 delta o ke kahawai calcium, uaʻikeʻia nō hoʻi e hoʻohanaʻia no kaʻeha neuropathic. Eia naʻe, hana ka hana kūpono i ke kikowaena a hiki ke hana i ka luhi, ka hilahila a me ka maikaʻiʻole.

 

Nā NānāʻOiʻole Opioid

 

Loaʻa ka loaʻaʻole o nāʻikeʻikepili ikaika e hoʻohana ana i nā lāʻau lapaʻau anti anti-inflammatory non-steroidal, aiʻole NSAID, ma ke kōkuaʻana i kaʻeha neuropathic. Hiki paha kēia ma muli o ka nele o kahi mea wela i ka hoʻohaʻahaʻaʻana i kaʻeha. Akā, ua hoʻohanaʻia lākou me ka opioids e like me nā mea kōkua ma ka hanaʻana i ka maʻi kanikau. Uaʻikeʻia kekahi pilikia, akā, ma nā mea maʻi nui i hoʻonāwaliwaliʻia.

 

ʻO nā opiid analgesics

 

ʻO nā analgesics o Opioid he kumuhana nui ia no ka hoʻonāukiukiʻana i kaʻeha neuropathic. Hana lākou i ka paleʻana i nā manaʻo nui o kaʻeha piʻi. ʻO ka mea maʻamau, ua nānā muaʻia kaʻeu neuropathic e lilo i opioid-resistant, kahi eʻoi aku ai keʻano o nā opioids no keʻano noʻonoʻoʻole a me nāʻano no ka maʻi. He nui nā kauka eʻaeʻole i ka hoʻohanaʻana i nā opioids e mālama i kaʻeha neuropathic, ma ka hapa nui no ka hopohopo e pili ana i ka hoʻohanaʻana i ka lāʻau lapaʻau, nā mea hōʻaho a me nā hoʻoponopono. Akā, ua nui nā ho'āʻo i loaʻa i nā'ōwili opioid e lanakila. ʻOi aku ka meaʻoi aku i kahibo no ka hoʻomahaʻana i kaʻeha, allodynia, hoʻomaikaʻi i ka moe a me ka hemahema. Hoʻopukaʻia nā opioids i hoʻoholoʻia, e like me ka hoʻonohonohoʻia, no nā maʻi me kaʻeha mau no ka hoʻouluʻana i nā wānana mau o ka analgesia, ka paleʻana i ka fluctuations i ke koko glucose a pale i nā hanaʻino e pili ana me nā pani kiʻekiʻe. ʻO kaʻoi aku o nā mea maʻamau, ua hoʻohanaʻia nā papa hana waha no kaʻoi aku o ka maʻalahi o ka hoʻohana a me ka waiwai kūpono. Hoʻomaopopo pinepineʻia nā papa hana pāʻaliʻi, nā mākuaeral a me nā hoʻoponoponoʻana i nā maʻi i hikiʻole keʻae i nā lāʻau lapaʻau.

 

Local Anesthetics

 

ʻO kahiʻoi aku o nāʻanoʻanoʻanoʻanoʻanoʻano heʻekeʻale e pili ana no ka mea, mahalo aku i kā lākou hana ākea, he hapa iki nā hopena. Hana lākou ma ka mālamaʻana i nā pūnaehu sodium ma nā axons o nā lālani mua. Hiki ke hana maikaʻi inā he nui wale nāʻeha o ke kīpē a me nā uala kahe i loaʻa. ʻO Topical lidocaine ka mea i koho maikaʻiʻia o ka papa hana no kaʻeha neuropathic. ʻO keʻano,ʻo ka hoʻohanaʻana i kēia māmā 5 i ka lidocaine papa no ka post-herpetic neuralgia ua hoʻonāʻia e ka FDA. Keʻike nei kaʻoihana i ka maikaʻi loa i ka wā i hoʻopōʻinoʻia ai, akā, hoʻomau,ʻoihana'ōlohelohe pūnaewele nociceptor mai kahi mea dermatome e hōʻike ana he allodynia. Pono pono e hoʻonohonoho ponoʻia ma kahi kikowaena no nā hola 12 a hoʻopauʻia no kekahi mau hola 12 a hiki ke hoʻohanaʻia no nā makahiki he mau makahiki. Ma waho aʻe o nāʻili o kaʻili i ke kino, hiki i nā maʻi he nui ke mālama i kaʻeha neuropathic.

 

Miscellaneous Drugs

 

Clonidine, he alpha-2-agonist, uaʻikeʻia he mea pono ma kahi'āpana o nā maʻi me ka neuropathy āpau o ka maʻi diabetic. Uaʻikeʻia nā cannabinoids e hana i ka hana ma ka hoʻonānea hoʻonāukiuki i nāʻano holoholona a me nāʻike o ka pono e loaʻa ana. CB2-nā mea hana'ākau e hoʻopau i ka hyperalgesia a me ka hoʻohui a normalize paepae no ka meaʻole ke kāohiʻana i ka analgesia.

 

ʻO ke kaʻina hanaʻino

 

Hiki ke noʻonoʻoʻia nā hōʻailona hōʻailona no nā maʻi i loaʻa kaʻeha neuropathic. ʻO kēia mau hōʻailona e komo pū i loko o ka hanana epidural a iʻole i nā kaona o nā mea anesthetics āpau a iʻole corticosteroids, ka hoʻokomoʻiaʻana o nā ala lawe lāʻau a me nā mea pili ponoʻole a me ka hoʻokomoʻana i nā mea stimulators o ka'ōpū. Hoʻopiliʻia kēia mau ala no nā poʻe maʻi me nāʻeha neuropathic kahemoʻole e hikiʻole ke hanaʻia a ua hanaʻole lākou i nāʻoihana olakino a me nāʻike loiloi. Ma kahi hoʻonaʻauaoʻana a Kim et al, ua hōʻikeʻia he mea hoʻoikaika ka hoʻonaniʻana o ka hōiho i ka hanaʻana i ka maʻi neuropathic o ke kumu aʻa aʻa.

 

Dr-Jimenez_White-Coat_01.png

Dr. Alex Jimenez's Insight

Me ka maʻi neuropathic, nā hōʻailona hōʻailona maʻamau i hanaʻia no kaʻili o ke aʻalolo i hoʻopōʻinoʻia, aiʻole i hōʻehaʻia aiʻole iʻeha, i hele mauʻia me kaʻino a me nāʻeha. Ma muli o kēia hopena, hiki i kēia mau aʻalolo ke hoʻomaka i ka hoʻounaʻana i nā hōʻailonaʻehaʻole i nā wahi'ē aʻe o ke kino. ʻO nā hopena o ke kaumaha neuropathic ma muli o nāʻehaʻeha o ke kīpona e pili ana i ka hoʻololiʻana i ka hana maʻamau ma ka pūnaewele o kaʻeha a ma nā wahi e pili ana i kaʻeha. ʻO ka hoʻomaopopoʻana i ka maʻi o ka maʻi neuropathic he pahuhopu ia no nā poʻeʻoihana olakino, i mea e hoʻoholo pono ai i ka hana maikaʻi loa e kōkua ai i ka hoʻoponoponoʻana a me ka hoʻomaikaʻiʻana i kona mau hōʻailona. Mai ka hoʻohanaʻana i nā lāʻau lapaʻau a me nā lāʻau lapaʻau, i ka mālamaʻana i ka lāʻau, ka hoʻolālā, kaʻoihana kino a me ka meaʻaiʻai, hiki ke hoʻohanaʻia nāʻano o nā mea e pono ai e hōʻeha i ka maʻi neuropathic no nā mea e pono ai kēlā me kēia.

 

Nā Hana hou aʻe no ka Paʻi Neuropathic

 

Nui nā maʻi i loaʻa i kaʻeha neuropathic e hahai i nā koho kōkua a me nāʻano'ē aʻe e hana ai i kaʻeha neuropathic. ʻO kekahi mauʻoihana kaulana i hoʻohanaʻia no ka mālamaʻana i kaʻeha neuropathic,ʻo ia hoʻi ka hōʻailona o ke kino, ka hoʻokalakupuaʻana o ke ea, keʻano o ka hoʻokalakupua elekene, ka hoʻomanaʻo i ka hana maʻamau, nā kiʻi kiʻi maʻamau a me ka mālamaʻana. Ma waena o kēia mau mea, he hana kūkino'ē aʻe ka mālamaʻana o ka chiropractic i ka hoʻohanaʻia e kōkua ai i ka hōʻehaʻana i nā neuropathic. ʻO ka lawelaweʻana o ke akua, me ka hoʻoikaika kino, ka hoʻomehanaʻana, ka meaʻai a me ka hoʻololi maikaʻi o ka nohoʻana e hiki ke hāʻawi i ka hoʻomaha no nā maʻi o ka neuropathic.

 

Ka Halewaiwai Chiropractic

 

ʻO ka mea iʻikeʻia he mea nui ka hoʻohanaʻana i ka hoʻohanaʻana i ka hoʻoponopono i nā hopena o kaʻeha neuropath. I kēiaʻano,ʻo ka mālama'ōlelo chiropractic he polokalamu hoʻolālā hoʻolālā holoʻokoʻa i hiki ke hana pono i ka paleʻana i nā hihia olakino e pili ana i nā pōʻino o ke kīpē. ʻO ke kōkuaʻana o Chiropractic i ke kōkuaʻana i nā maʻi me nāʻano likeʻole, a me nā mea e loaʻa ana i kaʻeha neuropathic. ʻO nā mea kū i ke kaumaha neuropathic ka hoʻohana pinepineʻana i nā lāʻau non-steroidal-anti-inflammatory, aiʻole NSAID, e like me ka ibuprofen, aiʻole nā ​​mea kākau kaumaha kaumaha e kōkua ai i kaʻeha neuropathic. Hiki iā lākou ke hāʻawi i kahi hanana lōʻihi akā pono e hoʻohana mau i ka hoʻohanaʻana i kaʻeha. ʻO kēia ka mea pili i nā hopena hopena maikaʻi a ma nā kūlana kūikawā, ka'ōlelo mālama lāʻau hōʻailona.

 

Hiki i nā hoʻopiʻi chiropractic ke kōkua i ka hoʻoikaikaʻana i nā hōʻailona o kaʻeha neuropathic a hoʻonui i ka pono me kaʻole o kēia mau mea. Hoʻokokokeʻia e like me ka hāʻawiʻana o nā chiropractic i kekahi papahana wikiō i hanaʻia eʻike i ke kumu kumu o ka hoʻopiʻiʻana. Ma o ka hoʻohanaʻana i nā hoʻololiʻana o ka'ōpū a me ka manuahi lima, hiki i kahi chiropractor ke hoʻoponopono pono i nā hōʻailona o ke kuamoʻo, aiʻole nā ​​subluxations, i loaʻa ma ka lōʻihi o ka'ōiwi, i hiki ke emi i nā hopena o ke kāpili pēpē ma o ka hoʻohālike o ka iwi hope. Hoʻouluʻia ka pono o ka'ōlohelohe i ka mālamaʻana i kahi pūnaewele nūnū waena kiʻekiʻe.

 

Hiki i ke kaukōwai ke hana i ka wā lōʻihi e hoʻonui i kou maikaʻi. Ma waho aʻe o ka hoʻoponoponoʻana i ka'ōpū a me ka manamana lima, hiki i kahi chiropractor ke hāʻawi aku i nā meaʻai kūpono, e like me ke kuhikuhiʻana i ka meaʻai waiwai i nā antioxidants, aiʻole e hana paha lākou i ka hoʻolālā kino aiʻole e hoʻolālā i ka papahana no ka hakakāʻana i nā maʻi o ke kino. ʻO ke kūlana lōʻihi e koi ai i kahi lapaʻau lōʻihi, a ma kēiaʻano, he mea waiwai nui ka mea lapaʻau e kū nei i nā meaʻeha a me nā kūlana e pili ana i ka musculoskeletal a me ke kino pūnaewele, e like me ke kauka o chiropractic a moʻo'ōlelo paha, e like me kā lākou hana e hoʻololi i ka loli maikaʻi i ka manawa.

 

Hoʻomaopopoʻia kaʻike o ke kino, nā hana hoʻolālā a me ka neʻeʻana i ka hana no ka hoʻoponoponoʻana i ka maʻi neuropathic. Hoʻomaopopo pūʻo Chiropractic i kekahi mauʻano lapaʻau e hiki ke kōkua i ka hoʻoponoponoʻana a iʻole ka hoʻonuiʻana i kaʻeha neuropathic. ʻO keʻano he lapaʻau laser haʻahaʻa, aiʻole LLLT paha, ua lanakila nui loaʻo ia ma keʻano he lapaʻau no kaʻeha neuropathic. Ma muli o keʻano o nā noiʻi noiʻi, ua hoʻoholoʻia he mau hopena maikaʻi ka LLLT ma ka mālamaʻana i nā kānalua no nā maʻi neuropathic, akā, pono eʻike houʻia nāʻano noiʻi noiʻi i nā kuʻina hana e hōʻuluʻulu i nā hopena o ka laser therapy ma nā neuropathic pain treatments.

 

ʻO keʻano o ka hoʻopuniʻana i nā meaʻai e pono ai ka mālamaʻana i nā hōʻailona e pili ana i ka neuropathy diabetes. Ma loko o kahi noiʻi noiʻi, ua hōʻikeʻia kahi mea kanu mea kanu momona i mea e hoʻonui ai i ka lāʻau glycemic i nā poʻe maʻi me ka maʻi maʻamauʻo 2. Ma hope o nā hola 20 o ka papa pilote, uaʻikeʻia nā mea i hoʻololiʻia i ka loli i ko lākou kino a me ke kino o nāʻili i nā mea'enele i ka wāwae. Ua hōʻikeʻia ka noiʻi noiʻi i kahi kūlana kūpono i ka meaʻaiʻai mea kanu kūpona no ka diabetic neuropathy. Eia kekahi, uaʻikeʻia nā haʻawina hoʻokolohua e hiki ke hanaʻia i ka lolo o ka magnesium L-threonate a me ka hoihoiʻana i nā nele o kaʻike ma muli o kaʻeha neuropathic.

 

Hiki i nā hoʻopiʻi hoʻopiʻi ke hāʻawi aku i nā kumu lapaʻau hou e hoʻoikaika i ka hoʻohuliʻana i nā aʻa. I kēia manawa, ua hoʻohālikelikeʻia ka hoʻonuiʻana i ka hoihoi houʻana o nā axons e kōkua i ka hoʻomaikaʻiʻana i ka hana ma hope o kaʻehaʻeha o ke kino. Ua hoʻoikaikaʻia ka hoʻolālā hana, me ka hoʻolālā a me nā hana kino, e hoʻoikaika i ka hoʻohouʻana o ke kīpē ma hope o ka hoʻoponoponoʻana o ke aʻalolo i nā kānaka a me nāʻiole, e like me nā noiʻi noiʻi. Ua hoʻoholo ikaikaʻia ka hoʻolālā a me ka hoʻolālā i ka hoʻoikaikaʻana i nā hōʻailona hoʻokolohua no nāʻehaʻeha o ke kino e pili ana e hoʻololiʻia i ka hoʻohanaʻana i ka lāʻau. Hiki paha i nāʻimi noiʻi hou e pono e hoʻoholo pono i nā hopena o kēia mau maʻi i nā maʻi neuropathic.

 

Panina

 

ʻO kaʻeha Neuropathic kahi hui multifaceted me ka ʻole o nā kulekele kikoʻī e mālama ai. Mālama maikaʻi ʻia me ka hoʻohana ʻana i kahi ala multidisciplinary. Pono ka mālama ʻeha i ka loiloi mau, ka hoʻomanawanui hoʻomanawanui ʻana, ka hōʻoia ʻana i ka ukali a me ka hōʻoia ʻana i ka mea maʻi. ʻO kaʻeha Neuropathic kahi kūlana mau loa e hana i ke koho no ka hoʻomaʻamaʻa maikaʻi ʻoi loa. ʻO ka hoʻomaʻamaʻa pilikino ʻana e pili ana i ka noʻonoʻo ʻana i ka hopena o ka ʻeha ma ke olakino o ke kanaka, ke kaumaha a me nā kino kīnā me ka hoʻomau o ka aʻo ʻana a me ka loiloi. ʻO nā noiʻi ʻeha Neuropathic, ma ka pae mole a me nā ʻano holoholona, ​​he mea hou akā hoʻohiki loa ia. Manaʻo ʻia nā hoʻomaikaʻi he nui i nā kahua maʻamau a me nā lāʻau lapaʻau o ka ʻeha neuropathic no laila e wehe ana i nā puka e hoʻomaikaʻi ai a i ʻole nā ​​ʻano hana hou no kēia kūlana hōʻino. ʻO ka laulā o kā mākou ʻike i kaupalena ʻia i ka chiropractic a me nā ʻeha a me nā kūlana spinal. E kūkākūkā i kēia kumuhana, e ʻoluʻolu e nīnau iā Dr. Jimenez a i ʻole e leka uila iā mākou915-850-0900 .

 

Hoʻopūʻia e Dr. Alex Jimenez

 

Green-Call-Now-Button-24H-150x150-2-3.png

 

Nā Pāhana Hou: Back Pain

 

Paʻi hope ʻo ia kekahi o nā kumu nui loa o ka hemahema a ua hala nā lā ma ka hana ma ka honua holoʻokoʻa. ʻOiai he meaʻoiaʻiʻo, ua hoʻokauʻia kaʻeha hope ma keʻano he kumu kumuʻelua no ka heleʻana o ke keʻena o ke kauka,ʻoi aku ma mua wale nō nā maʻi āpau kiʻekiʻe. Ma kahi o 80 pakeneka o ka heluna eʻike i kekahiʻano o kaʻeha hope loa ma kahi o hoʻokahi manawa ma ko lākou ola. ʻO ka'ōiwi kahi hanana paʻapū i hanaʻia i ka iwi, nā hono, nā ligaments a me nāʻiʻo, i waena o nā mea'ē aʻe. Ma muli o kēia, nāʻeha a me nā kūlana hōʻeha, e like me nā kīlei'aniani, hiki ke hopena i nā hōʻailona o ke kaumaha hope. ʻO nāʻeha a me nāʻeha a me nā pōpilikia pū kaʻa paha he kumu pinepine ia o kaʻehaʻeha, akā, i kekahi manawa,ʻoi aku kaʻoi loa o nā hana i loaʻa i nā hopenaʻeha. ʻO ka mea pōmaikaʻi, hiki i nā koho hoʻoponopono'ē aʻe, e like me ka mālamaʻana i ka chiropractic, ke kōkua i ka pale i kaʻeha ma o ka hoʻohanaʻana i nā hoʻololiʻana o ka'ōpū a me nā lima lima, me ka hoʻomaikaʻi maikaʻi i nā maʻi.

 

 

 

blog blog of hawaiian cartoon big news

 

KA HOʻOPIʻI MANAʻO KAULAHI: Ke Kūlana Paena Paʻi Loa

 

Nā ʻ Mlelo Aʻe: EXTRA EXTRA: ʻChronic Pain & Treatments

 

Hoʻonui ka Loss Moe i ka Poino o ka Iwa

Hoʻonui ka Loss Moe i ka Poino o ka Iwa

ʻO ka liloʻana o ka hiamoe e hoʻonui i ka mea nui e lilo i mea nui, e like me ka'ōlelo Suède. Nānā nā kānaka noiʻi mai Uepsala University i ka nele o ka hiamoe e pili ana i ka hopena pūnaewele ma ka hoʻonāukiukiʻana i nā hiʻohiʻona moe a hoʻopili i ka pane o ke kino i kaʻai a me ka hoʻolālā.

ʻOiai uaʻikeʻia he mau hanana i kahi pilina ma waena o ka hiamoe moe a me ka waiwai waiwai,ʻaʻole i maopopo i ke kumu.

Ua alakaʻiʻo Kauka Christian Benedict a me kona mau hoa i nā hanana kanaka e nānā i keʻano o ka hopena o ka hiamoe e pili i ka hoʻoikaika i ka ikehu. Ua ana aʻikeʻia kēia mau aʻoʻana i nā pane, nā physiological, a me nāʻano biochemic i ka meaʻai ma hope o ka pōʻino nui o ka hiamoe.

Hōʻikeʻia nā hōʻike i nā mea iʻikeʻia e nā kānaka e ola ai ka maikaʻi, e hoʻonele i ka nui o nā meaʻai, e huli i nā calorie hou, e hōʻike i nā hōʻailona o ka nui o ka pulupili e pili ana i ka meaʻai, a hoʻemi i ka ike.

Ke hōʻikeʻia nei nā haʻawina physiological a ka hui e pale ana ka hiamoe i ka pale hormonal mai nā hormones e hoʻonui i ka piha (satiety), e like me GLP-1, i ka poʻe e hoʻoikaika i ka pōloli, e like me ghrelin. Hoʻopiʻi ka moe no nā piʻi piʻi o endocannabinoids, iʻikeʻia e hoʻonā i ka makemake.

Eia hou, ua hōʻikeʻia kā lākou noiʻiʻana i ka nui o ka moe e hoʻololi i ke kaulike o ka huapiʻona kino, i hoʻolaha nuiʻia e like me keʻano no ka mālamaʻana i ka pili olakino. Uaʻike pūʻia kaʻikeʻana i ka liʻiliʻi i ka insulin mahope o ka moeʻana o ka moe.

Ma muli o kēia mau haʻawina e hōʻike ana i kēia mau mea,ʻaʻole ia he mea e piliʻi i nā maʻi o ka maʻi, e like me ka nui o nā mea nui i loaʻa i ka nui, "wahi a Benedict.

"ʻO kaʻu mau aʻoʻana e kuhikuhi nei i ka nele o ka hiamoe i ka waiwai waiwai i loko o nā kānaka," i'ōlelo aiʻo ia. "E hiki nō paha ke hoʻoholoʻia e hoʻomaikaʻi i ka moe ka mea ola e like me ka hanaʻana e hoʻemi i ka hopena o ka waiwai waiwai."

ʻAʻole wale ka nui o ka hiamoe e hoʻonui i ka paona, uaʻike kekahi mauʻimi noiʻi ua nui ka mālamalama i kou hiamoeʻana e hiki ai ke hoʻonui i kou pilikia no ka momona. Uaʻikeʻia kahi hana Pelekānia o nā 113,000 wahine i ka māmāʻana o nā hiʻohiʻona iʻikeʻia i loko o nā hola moe,ʻo kaʻoi aku ka nui o ka nui o ka momona. Hoʻopilikia ke kukui i ke kani o ke kino o ke kino, e pili ana i ka moe a me nā hiʻohiʻona hoʻomalu, a pēlā nō hoʻi e pili ana i ka hanana.

Akāʻo ka hikiʻana i ka mālamalama i nā hola hoʻomaha mua hiki ke kōkua i ka mālamaʻana i ke kaumaha. Uaʻike kekahi haʻawina mai ka Kulanui o Northwestern i nā poʻe i loaʻa ka hapa nui o kaʻikeʻana i ka lā, inā paha heʻeleʻele ia, i ka hoʻomakaʻana o ka lā, he kaʻina o ke kino o ka maʻi (BMI) ma mua o ka poʻe iʻikeʻia i ka lā ma hope o ka lā, ka hana, ka hopena caloric, aiʻole ka makahiki.